Effects of MMP-9 on plaque rupture: development of a novel model for acute coronary syndromes.

• Project/Area Number: 23590401
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Saga University
• Principal Investigator: WATANABE Teruo 佐賀大学, 総合分析実験センター, 客員研究員 (40037396)
• Co-Investigator(Kenkyū-buntansha): FAN Jianglin 山梨大学, 医学工学総合研究部, 教授 (60272192) ; KITAJIMA Shuji 佐賀大学, 総合分析実験センター, 准教授 (70284643) ; NISHIJIMA Kazutoshi 佐賀大学, 総合分析実験センター, 助教 (70435874)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: MMP-9 / 動脈硬化 / 遺伝子組換え / ウサギ / 病態モデル

Research Abstract

Matrix metalloprotease (MMP)-9 transgenic (Tg) rabbits were analyzed to clarify the effects of MMP-9 on atherosclerosis. With high cholesterol diet loading, the arteriosclerotic lesion in MMP-9 Tg rabbit was larger than in control rabbit. Subsequently, MMP-9 Tg rabbit was mated with MMP-12 (known to accelerate the initiation of atherosclerosis) Tg rabbit and MMP-9/12 Tg rabbit was established as a candidate for a novel model for acute coronary syndromes.

Research Products

• [Journal Article] Peroxiredoxin 4 protects against nonalcoholic steatohepatitis and type 2 diabetes in a nongenetic mouse model (2013)
  • Author(s): Nabeshima A, Yamada S, Guo X, Tanimoto A, Wang KY, Shimajiri S, Kimura S, Tasaki T, Noguchi H, Kitada S, Watanabe T, Fujii J, Kohno K, Sasaguri Y
  • Journal Title: Antioxid Redox Signal Volume: 19 Pages: 1983-98
  • Peer Reviewed
• [Journal Article] Human apolipoprotein A-II protects against diet-induced atherosclerosis in transgenic rabbits (2013)
  • Author(s): Wang Y, Niimi M, Nishijima K, Waqar AB, Yu Y, Koike T, Kitajima S, Liu E, Inoue T, Kohashi M, Keyamura Y, Yoshikawa T, Zhang J, Ma L, Zha X, Watanabe T, Asada Y, Chen YE, Fan J
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33 Pages: 224-31
  • Peer Reviewed
• [Journal Article] Overexpression of peroxiredoxin 4 attenuates atherosclerosis in apolipoprotein E knockout mice (2012)
  • Author(s): Guo X, Yamada S, Tanimoto A, Ding Y, Wang KY, Shimajiri S, Murata Y, Kimura S, Tasaki T, Nabeshima A, Watanabe T, Kohno K, Sasaguri Y
  • Journal Title: Antioxid Redox Signal Volume: 17 Pages: 1362-75
  • Peer Reviewed