The basic study of molecular targeted therapy via pancreatic duct tight junctions by using a novel culture system of human pancreatic duct epithelial cells

• Project/Area Number: 23590404
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Sapporo Medical University
• Principal Investigator: KOJIMA Takashi 札幌医科大学, 医学部, 教授 (30260764)
• Co-Investigator(Renkei-kenkyūsha): MURATA Masaki 札幌医科大学, 医学部, 講師 (10404592) ; TAKASAWA Akira 札幌医科大学, 医学部, 助教 (00593021)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヒト正常膵管上皮細胞 / 膵癌 / 分子標的治療 / PKC / claudin / 抗癌剤 / タイト結合

Research Abstract

In the present study, using normal human pancreatic duct epithelial cells and cancer cell lines. we investigated the basic study targeting tight junction molecules claudin-4, -18 and a signal molecule PKC that highly expressed in pancreatic cancer. Claudin-4 and -18 were regulated via a PKCalpha signal transduction pathway in both human pancreatic duct epithelial cells and cancer cells. The cytotoxic effects of CPE via claudin-4 are thought to be useful as a novel therapeutic tool for pancreatic cancer. The cytotoxicity was not observed at any concentration of CPE, whereas in pancreatic cancer cells, CPE had a dose-dependent cytotoxic effect. PKCalpha inhibitors represent potential therapeutic agents against human pancreatic cancer cells by the use of CPE cytotoxicity via claudin-4.

Research Products

• [Journal Article] Pseudomonas aeruginosa elastase causes transient disruption of tight junctions and downregulation of PAR-2 in human nasal epithelial cells (2014)
  • Author(s): Nomura K, Takano K, Himi T, Kojima T. (10名, 9, 10番)
  • Journal Title: Respir Res Volume: 18 Issue: 1 Pages: 15-21
  • DOI: 10.1186/1465-9921-15-21
  • Peer Reviewed / Open Access
• [Journal Article] Expression of tricellulin in epithelail cells and non-epithelial cells (2013)
  • Author(s): Kojima T, Ninomiya T, Konno T, Kohno T, Taniguchi M, Sawada N
  • Journal Title: Histol Histopathol Volume: 28 Pages: 1383-1392
  • URL: http://www.hh.um.es/Abstracts/Vol_28/28_11/28_11_1383.htm
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Kojima T, Yamaguchi H, Ito T, Kyuno D, Kono T, Konno T, Sawada N
  • Journal Title: Tissue Barriers Volume: 1 Issue: 4 Pages: e24894-e24894
  • DOI: 10.4161/tisb.24894
  • Peer Reviewed
• [Journal Article] Protein kinase Cα inhibitor protects against downregulation of claudin-1 during epithelial-mesenchymal transition of pancreatic cancer. (2013)
  • Author(s): Kyuno D, Kojima T, Yamaguchi H, Ito T, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
  • Journal Title: Carcinogenesis Volume: 34 Issue: 6 Pages: 1232-1243
  • DOI: 10.1093/carcin/bgt057
  • Peer Reviewed
• [Journal Article] Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions (2013)
  • Author(s): Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N
  • Journal Title: Cell Tissue Res Volume: 351(1) Issue: 1 Pages: 73-84
  • DOI: 10.1007/s00441-012-1512-7
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions in upper airway epithelium (2013)
  • Author(s): Kojima T, Takano K, Himi T(全19名1, 3, 18番)
  • Journal Title: Biomed Res Int Volume: 2013 Pages: 947072-947072
  • DOI: 10.1155/2013/947072
  • Peer Reviewed
• [Journal Article] Curcumin prevents replication of RS virus and the epithelial responses to it in human nasal epithelial cells (2013)
  • Author(s): Obata K, Kojima T, Yokota S, Tsutsumi H, Himi T. (全15名2, 14番)
  • Journal Title: PLoS One Volume: 8(9) Issue: 9 Pages: 70225-70225
  • DOI: 10.1371/journal.pone.0070225
  • Peer Reviewed
• [Journal Article] Marked induction of MMP-10 by RS virus infection in human nasal epithelial cells (2013)
  • Author(s): Hirakawa S, Kojima T, Yokota SI, Himi T,, (全15名5, 9番)
  • Journal Title: J Med Virol Volume: 85(12) Issue: 12 Pages: 2141-50
  • DOI: 10.1002/jmv.23718
  • Peer Reviewed
• [Journal Article] Humulone suppresses replication of RS virus and release of IL-8 and RANTES in normal human nasal epithelial cells (2013)
  • Author(s): Fuchimoto J, Kojima T, Yokota SI, Himi T(全15名2. 14番)
  • Journal Title: Med Mol Morphol Volume: 46(4) Issue: 4 Pages: 203-9
  • DOI: 10.1007/s00795-013-0024-1
  • Peer Reviewed
• [Journal Article] Targeting claudin-4 in human pancreatic cancerRegulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano (2013)
  • Author(s): Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N
  • Journal Title: Cell Tissue Res. 2013 Volume: 354 Pages: 481-494
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions by sex hormones in normal human endometrial epithelial cells and uterus cancer cell line Sawano. (2013)
  • Author(s): Someya M, Kojima T, Ogawa M, Ninomiya T, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
  • Journal Title: Cell Tissue Res. Volume: 354 Issue: 2 Pages: 481-494
  • DOI: 10.1007/s00441-013-1676-9
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions in human pancreatic duct epithelial cells. (2013)
  • Author(s): Kojima T, Yamaguchi H, Ito T, Kyuno D, Kono T, Konno T, Sawada N.
  • Journal Title: Tissue Barriers Volume: 1
  • Peer Reviewed
• [Journal Article] Expression of tricellulin in epithelail cells and non-epithelial cells. (2013)
  • Author(s): Kojima T, Ninomiya T, Konno T, Kohno T, Taniguchi M, Sawada N.
  • Journal Title: Histol Histopathol. Volume: 28 Pages: 1383-1392
  • Peer Reviewed
• [Journal Article] Changes of Tight Junction Protein Claudins in Small Intestine and Kidney Tissues of Mice Fed a DDC Diet (2013)
  • Author(s): Abiko Y, Kojima T, Murata M, Tsujiwaki M, Takeuchi M, Sawada N, Mori M.
  • Journal Title: Journal of Toxicologic Pathology Volume: 26 Issue: 4 Pages: 433-438
  • DOI: 10.1293/tox.2013-0009
  • NAID: 130003382454
  • ISSN: 0914-9198, 1881-915X
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions in upper airway epithelium. (2013)
  • Author(s): Kojima T, Go M, Takano K, Kurose M, Ohkuni T, Koizumi J, Kamekura R, Ogasawara N, Masaki T, Fuchimoto J, Obata K, Hirakawa S, Nomura K, Keira T, Miyata R, Fujii N, Tsutsumi H, Himi T
  • Journal Title: Biomed Res Int Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Behavior of tricellulin during destruction and formation of tight junctions under various extracellular calcium conditions. (2013)
  • Author(s): Takasawa A, Kojima T, Ninomiya T, Tsujiwaki M, Murata M, Tanaka S, Sawada N.
  • Journal Title: Cell Tissue Res Volume: 351 Pages: 73-84
  • Peer Reviewed
• [Journal Article] Targeting claudin-4 in human pancreatic cancer (2012)
  • Author(s): Kojima T, Kyuno D, Sawada N
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: 16 Issue: 9 Pages: 881-887
  • DOI: 10.1517/14728222.2012.708340
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells (2012)
  • Author(s): Kojima T, Sawada N
  • Journal Title: Ann N Y Acad Sci Volume: 1257 Issue: 1 Pages: 85-92
  • DOI: 10.1111/j.1749-6632.2012.06579.x
  • Peer Reviewed
• [Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells (2012)
  • Author(s): Fuchimoto J, Kojima T, Himi T(全12名2, 11番)
  • Journal Title: Am J Rhinol Allergy Volume: 26(6) Issue: 6 Pages: 433-8
  • DOI: 10.2500/ajra.2012.26.3814
  • Peer Reviewed
• [Journal Article] Effects of atelocollagen formulation containing oligonucleotide on endothelial permeability (2012)
  • Author(s): Hanai K, Kojima T, Ota M, Onodera J, Sawada N.
  • Journal Title: J Drug Deliv Volume: 2012 Pages: 245835-245835
  • DOI: 10.1155/2012/245835
  • Peer Reviewed
• [Journal Article] Regulation of IL-33 and TSLP in human nasal fibroblasts by proinflammatory cytokines (2012)
  • Author(s): Nomura K, Kojima T, Himi T(全7名2. 6番)
  • Journal Title: Laryngoscope Volume: 122(6) Issue: 6 Pages: 1185-92
  • DOI: 10.1002/lary.23261
  • Peer Reviewed
• [Journal Article] Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation (2012)
  • Author(s): Soini Y, Takasawa A, Eskelinen M, Juvonen P, Karja V, Hasegawa T, Murata M, Tanaka S, Kojima T, Sawada N
  • Journal Title: J Clin Pathol Volume: 65(5) Issue: 5 Pages: 431-436
  • DOI: 10.1136/jclinpath-2011-200400
  • Peer Reviewed
• [Journal Article] The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis (2012)
  • Author(s): Kamekura R, Kojima T, Himi T(全6名2, 6番)
  • Journal Title: Clin Exp Allergy Volume: 42(2) Issue: 2 Pages: 218-28
  • DOI: 10.1111/j.1365-2222.2011.03867.x
  • Peer Reviewed
• [Journal Article] Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer (2012)
  • Author(s): Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N
  • Journal Title: Prostate Volume: 72(4) Issue: 4 Pages: 351-360
  • DOI: 10.1002/pros.21436
  • Peer Reviewed
• [Journal Article] Regulation of tight junctions in human normal pancreatic duct epithelial cells and cancer cells. (2012)
  • Author(s): Kojima T, Sawada N.
  • Journal Title: Ann N Y Acad Sci Volume: 1257 Pages: 85-92
  • Peer Reviewed
• [Journal Article] Targeting claudin-4 in human pancreatic cancer. (2012)
  • Author(s): Kojima T, Kyuno D, Sawada N.
  • Journal Title: Expert Opinion on Therapeutic Targets Volume: 16 Pages: 881-887
  • Peer Reviewed
• [Journal Article] Claudin-4-targeted therapy using Clostridium perfringens enterotoxin for prostate cancer. (2012)
  • Author(s): Maeda T, Murata M, Chiba H, Takasawa A, Tanaka S, Kojima T, Masumori N, Tsukamoto T, Sawada N.
  • Journal Title: Prostate Volume: 72 Pages: 351-360
  • Peer Reviewed
• [Journal Article] The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis. (2012)
  • Author(s): Kamekura R, Kojima T, Takano K, Go M, Sawada N, Himi T.
  • Journal Title: Clinical & Experimental Allergy Volume: 42 Pages: 218-228
  • Peer Reviewed
• [Journal Article] Expression of claudins 7 and 18 in pancreatic ductal adenocarcinoma: association with features of differentiation. (2012)
  • Author(s): Soini Y, Takasawa A, Eskelinen M, Juvonen P, Ka¨rja¨ V, Hasegawa T, Murata M, Tanaka S, Kojima T, Sawada N.
  • Journal Title: J Clin Pathol Volume: 65 Pages: 431-436
• [Journal Article] Regulation of IL-33 and TSLP in human nasal fibroblasts by proinflammatory cytokines. (2012)
  • Author(s): Nomura K, Kojima T, Fuchimoto J, Obata K, Keira T, Himi T, Sawada N.
  • Journal Title: Laryngoscope Volume: 122 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Effects of atelocollagen formulation containing oligonucleotide on endothelial permeability. (2012)
  • Author(s): Hanai K, Kojima T, Ota M, Onodera J, Sawada N.
  • Journal Title: J Drug Deliv Volume: 2012 Pages: 245835-245835
  • Peer Reviewed
• [Journal Article] Ichimiya S. Sorting Nexin 5 of a New Diagnostic Marker of Papillary Thyroid Carcinoma Regulates Caspase-2. (2012)
  • Author(s): Ara S., Kikuchi T., Matsumiya H., Kojima T., Kubo T., Ye R., Sato A., Kon S., Honma T., Asakura K., Hasegawa T., Himi T., Sato N.
  • Journal Title: Cancer Sci Volume: 103 Pages: 1356-1362
  • Peer Reviewed
• [Journal Article] Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines. (2012)
  • Author(s): Ogawa M, Kojima T, Someya M, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.
  • Journal Title: Histochem Cell Biol Volume: 138 Pages: 323-338
  • Peer Reviewed
• [Journal Article] Hop water extract inhibits double-stranded RNA-induced thymic stromal lymphopoietin release from human nasal epithelial cells. (2012)
  • Author(s): Fuchimoto J, Kojima T, Kobayashi N, Ohkuni T, Ogasawara N, Masaki T, Obata K, Nomura K, Kondoh A, Shigyo T, Himi T, Sawada N.
  • Journal Title: Am J Rhinol Allergy Volume: 26 Pages: 433-438
  • Peer Reviewed
• [Journal Article] Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells (2011)
  • Author(s): Kojima T, Takasawa A, Kyuno D, Ito T, Yamaguchi H, Hirata K, Tsujiwaki M, Murata M, Tanaka S, Sawada N
  • Journal Title: Exp Cell Res Volume: 317(16) Issue: 16 Pages: 2288-2298
  • DOI: 10.1016/j.yexcr.2011.06.020
  • Peer Reviewed
• [Journal Article] An NF-・B signaling pathway via PKC・regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells (2011)
  • Author(s): Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N
  • Journal Title: Mol Biol Cell Volume: 22(13) Issue: 13 Pages: 2144-2156
  • DOI: 10.1091/mbc.e10-11-0875
  • Peer Reviewed
• [Journal Article] Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells (2011)
  • Author(s): Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, Hirata K, Sawada N
  • Journal Title: Cell Mol Biol Lett Volume: 16 Issue: 3 Pages: 385-397
  • DOI: 10.2478/s11658-011-0014-z
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA methylation in human pancreatic cancaer cells (2011)
  • Author(s): Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N
  • Journal Title: J Cell Biochem Volume: 112(7) Issue: 7 Pages: 1761-72
  • DOI: 10.1002/jcb.23095
  • Peer Reviewed
• [Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma (2011)
  • Author(s): Kondoh A, Takano K, Kojima T, Himi T (全9名2, 3, 9番)
  • Journal Title: Acta Otolaryngol Volume: 131(8) Issue: 8 Pages: 861-8
  • DOI: 10.3109/00016489.2011.562537
  • Peer Reviewed
• [Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-・via distinct NF-・B pathways in human nasal epithelial cells (2011)
  • Author(s): Ohkuni T, Kojima T , Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi J, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N
  • Journal Title: Toxicology and Applied Pharmacology Volume: 250 Issue: 1 Pages: 29-38
  • DOI: 10.1016/j.taap.2010.09.023
  • Peer Reviewed
• [Journal Article] Expression and function of claudins in hepatocytes. CLAUDINS : METHODS AND PROTOCOLS (2011)
  • Author(s): Kojima T, Sawada N
  • Journal Title: Methods Mol Biol Volume: 762 Pages: 233-24
  • DOI: 10.1007/978-1-61779-185-7_16
  • ISBN: 9781617791840, 9781617791857
  • Peer Reviewed
• [Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids (2011)
  • Author(s): Ogasawara N, Kojima T, Takano K, Himi T(全13名2, 3, 13番)
  • Journal Title: Acta Otolaryngol Volume: 131 Issue: 2 Pages: 116-23
  • DOI: 10.3109/00016489.2010.520022
  • Peer Reviewed
• [Journal Article] Epithelial barrier and antigen uptake in lymphoepithelium of human adenoids. (2011)
  • Author(s): Ogasawara N, Kojima T, Go M, Takano KI, Kamekura R, Ohkuni T, Koizumi JI, Masaki T, Fuchimoto J, Obata K, Kurose M, Shintani T, Sawada N, Himi T.
  • Journal Title: Acta Otolaryngol Volume: 131 Pages: 116-123
  • Peer Reviewed
• [Journal Article] Poly(I:C) reduces expression of JAM-A and induces secretion of IL-8 and TNF-α via distinct NF-κB pathways in human nasal epithelial cells. (2011)
  • Author(s): Ohkuni T, Kojima T, Ogasawara N, Masaki T, Fuchimoto J, Kamekura R, Koizumi JI, Ichimiya S, Murata M, Tanaka S, Himi T, Sawada N.
  • Journal Title: Toxicol Appl Pharmacol Volume: 250 Pages: 29-38
  • Peer Reviewed
• [Journal Article] Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. (2011)
  • Author(s): Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N, Himi T.
  • Journal Title: Acta-Otolaryngol Volume: 131 Pages: 861-868
  • Peer Reviewed
• [Journal Article] Transcriptional regulation of claudin-18 via specific protein kinase C signaling pathways and modification of DNA-methylation in human pancreatic cancer cells. (2011)
  • Author(s): Ito T, Kojima T, Yamaguchi H, Kyuno D, Kimura Y, Imamura M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N.
  • Journal Title: J Cell Biochem Volume: 112 Pages: 1761-1772
  • Peer Reviewed
• [Journal Article] Effects of Clostridium perfringens enterotoxin via claudin-4 on normal human pancreatic duct epithelial cells and cancer cells. (2011)
  • Author(s): Yamaguchi H, Kojima T, Ito T, Kyuno D, Kimura Y, Imamura M, Hirata K, Sawada N.
  • Journal Title: Cell Mol Biol Lett Volume: 16 Pages: 385-397
  • Peer Reviewed
• [Journal Article] An NF-κB signaling pathway via PKCδ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells. (2011)
  • Author(s): Masaki T, Kojima T, Okabayashi T, Ogasawara N, Ohkuni T, Obata K, Takasawa A, Murata M, Tanaka S, Hirakawa S, Fuchimoto J, Ninomiya T, Fujii N, Tsutsumi H, Himi T, Sawada N.
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 1-13
  • Peer Reviewed
• [Journal Article] Downregulation of tight junction-associated MARVEL protein marvelD3 during epithelial-mesenchymal transition in human pancreatic cancer cells. (2011)
  • Author(s): Kojima T, Takasawa A, Kyuno, Tatsuya Ito T, Yamaguchi H, Hirata K, Tsujiwaki, Murata M, Tanaka S, Sawada N.
  • Journal Title: Exp Cell Res Volume: 317 Pages: 2288-2298
  • Peer Reviewed
• [Journal Article] Pulmonary collectins attenuate growth of M. avium. (2011)
  • Author(s): Ariki S, Kojima T, Gasa S, Saito A, Nishitani C, Takahashi M, Shimizu T, Yuichiro Kurimura Y, Sawada N, Fujii N, Kuroki Y.
  • Journal Title: J Immonol Volume: 187 Pages: 2586-2594
  • Peer Reviewed
• [Journal Article] Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells. (2011)
  • Author(s): Okabayashi T, Kojima T, Masaki T, Yokota SI, Imaizumi T, Tsutsumi H, Himi T, Fujii N, Sawada N.
  • Journal Title: Virus Res Volume: 160 Pages: 360-366
  • Peer Reviewed
• [Journal Article] Protein kinase Cα inhibitor enhances sensitivity of human pancreatic cancer HPAC cells to Clostridium perfringens enterotoxin via claudin-4. (2011)
  • Author(s): Kyuno D, Kojima T, Ito T, Yamaguchi H, Tsujiwaki M, Takasawa A, Murata M, Tanaka S, Hirata K, Sawada N,
  • Journal Title: Cell Tissue Res Volume: 346 Pages: 369-381
  • Peer Reviewed
• [Journal Article] Mucosal immune barrier and antigen-presenting system in human nasal epithelial cells. (2011)
  • Author(s): Himi T, Takano K, Ogasawara N, Go M, Kurose M, Koizumi J, Kamekura R, Kondo A, Ohkuni T, Masaki T, Kojima T, Sawada N,Tsutsumi H.
  • Journal Title: Adv Otorhinolaryngol Volume: 72 Pages: 28-30
• [Journal Article] Respiratory syncytial virus infection and the tight junctions of nasal epithelial cells. (2011)
  • Author(s): Tsutsumi H, Kojima T, Hirakawa S, Masaki T, Okabayashi T, Yokota S, Fujii N, Himi T, Sawada N.
  • Journal Title: Adv Otorhinolaryngol Volume: 72 Pages: 153-156
• [Presentation] ヒト膵管上皮細胞株におけるJun N-terminal kinase (JNK)阻害剤によるバリア機能および細胞の高さの亢進 (2013)
  • Author(s): 小島隆
  • Organizer: 第65回日本細胞生物学会
  • Place of Presentation: 名古屋
• [Presentation] PKCα阻害剤は膵癌細胞のEMTにおけるタイト結合分子claudin-1の低下を抑制する (2013)
  • Author(s): 及能大輔, 小島隆
  • Organizer: 第114回日本外科学会
  • Place of Presentation: 京都
• [Presentation] ヒト膵管上皮細胞株におけるJun N-terminal kinase (JNK) 阻害剤によるバリア機能および細胞の高さの亢進 (2013)
  • Author(s): 小島隆ら
  • Organizer: 第65回日本細胞生物学会
  • Place of Presentation: 名古屋
• [Presentation] 正常ヒト膵菅上皮細胞および膵癌細胞におけるclaudinの発現調節機構の解明 (2013)
  • Author(s): 小島隆, 澤田典均
  • Organizer: 第45回日本臨床分子形態学会
  • Place of Presentation: 福岡
• [Presentation] ヒト膵管上皮細胞株におけるJun N-terminal kinase (JNK)阻害剤によるバリア機能および細胞の高さの亢進 (2012)
  • Author(s): 小島隆,金野匠,及能大輔,澤田典均
  • Organizer: 第44回日本臨床分子形態学会
  • Place of Presentation: 高知
• [Presentation] 正常ヒト膵菅上皮細胞および膵癌細胞におけるclaudinの発現調節機構の解明 (2012)
  • Author(s): 小島隆,澤田典均
  • Organizer: 第45回日本臨床分子形態学会,第62回日本顕微鏡学会
  • Place of Presentation: 福岡
• [Presentation] Protein kinase C-alpha regulates claudin-1 via Snail-dependent and -independent pathway in pancreatic cancer. (2012)
  • Author(s): Kyuno D., Kojima T., et al.
  • Organizer: Pancreas Cancer 2012
  • Place of Presentation: 京都
• [Presentation] Regulation of claudin-4 via protein kinase C signal pathway in normal human pancreatic duct epithelial cells and cancer cells. (2012)
  • Author(s): Yamaguchi H., Kojima T., et al.
  • Organizer: Pancreas Cancer 2012
  • Place of Presentation: 京都
• [Presentation] ヒト鼻粘膜上皮細胞におけるRSVの複製阻害およびタイト結合の発現誘導機構の解明 (2012)
  • Author(s): 小幡和史 小島隆 ら
  • Organizer: 第33回 日本炎症再生学会
  • Place of Presentation: 福岡
• [Presentation] PKC・阻害剤によるタイト結合分子を介した膵癌分子標的治療の基礎的研究 (2012)
  • Author(s): 及能大輔、小島隆 ら
  • Organizer: 日本外科学会
  • Place of Presentation: 千葉
• [Presentation] PKC-alpha regulates claudin-1 via Snail gene in pancreatic cancer (2012)
  • Author(s): Kyuno D., Kojima T., et al.
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
• [Presentation] Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines (2012)
  • Author(s): Ogawa M., Kojima T., et al.
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
• [Presentation] ヒト膵管上皮細胞株におけるJun N-terminal kinase (JNK) 阻害剤によるバリア機能の亢進 (2012)
  • Author(s): 金野匠, 小島隆 ら
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] ヒト鼻粘膜上皮細胞系におけるrespiratory syncytial virus感染によるMatrix Metalloproteinaseの増加 (2012)
  • Author(s): 平川賢史、小島隆、ら
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 緑膿菌産生エラスターゼによるヒト鼻粘膜上皮バリアへの影響 (2012)
  • Author(s): 野村一顕、小島隆 ら
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] ヒト膵管上皮細胞株におけるJun N-terminal kinase (JNK) 阻害剤による (2012)
  • Author(s): 小島隆
  • Organizer: 第44回日本臨床分子形態学学会
  • Place of Presentation: 高知
• [Presentation] Respiratory Syncytial Virusのウイルスフィラメント形成におけるRho/ROCK pathwayの影響 (2012)
  • Author(s): 平川賢史、小島隆ら
  • Organizer: 第44回日本臨床分子形態学学会
  • Place of Presentation: 高知
• [Presentation] Regulation of tight junctions in normal human pancreatic duct epithelial cells and cancer cells (2011)
  • Author(s): Kojima T
  • Organizer: International conference, Berlin 2011
  • Place of Presentation: Berlin, Germany
• [Presentation] シンポジウムヒト膵菅上皮細胞におけるタイト結合の調節機構 (2011)
  • Author(s): 小島隆
  • Organizer: 第62回日本顕微鏡学会
  • Place of Presentation: 福岡
• [Presentation] ヒト膵菅上皮細胞におけるタイト結合の調節機構 (2011)
  • Author(s): 小島 隆
  • Organizer: 第62回日本顕微鏡学会(招待講演)
  • Place of Presentation: 福岡
• [Presentation] Regulation of tight junctions in normal human pancreatic duct epithelial cells and cancer cells. (2011)
  • Author(s): Kojima T.
  • Organizer: International conference, Berlin 2011 "Barriers and channels formed by tight junction proteins-From mechanisms to disease and back"(招待講演)
  • Place of Presentation: Berlin, Germany
• [Book] 細胞間結合装置.病気の分子形態学.日本臨床分子形態学会編 (2011)
  • Author(s): 小島隆,村田雅樹,高澤啓,田中敏,澤田典均
  • Publisher: 学際企画
• [Book] Expression and function of claudins in hepatocytes. CLAUDINS: METHODS AND PROTOCOLS (2011)
  • Author(s): Kojima T, Sawada N.
  • Total Pages: 12
  • Publisher: Methods Mol Biol, Human press
• [Book] Tight junctions in upper airway epithelium. Endothelium and Epithelium: Composition, Functions and Pathology (2011)
  • Author(s): Kojima T, Himi T, Tsutsumi H, Sawada N.
  • Total Pages: 17
  • Publisher: Edited by Carrasco E and Mota M. Nova Science Publishers
• [Book] 細胞間結合装置. 病気の分子形態学. (2011)
  • Author(s): 小島隆, 村田雅樹, 高澤啓, 田中敏, 澤田典均.
  • Total Pages: 4
  • Publisher: 日本臨床分子形態学会編 学際企画
• [Book] 鼻アレルギーとタイト結合. 病気の分子形態学. (2011)
  • Author(s): 高野賢一, 郷充, 亀倉隆太, 小島隆.
  • Total Pages: 2
  • Publisher: 日本臨床分子形態学会編 学際企画
• [Book] 慢性扁桃炎とタイト結合. 病気の分子形態学. (2011)
  • Author(s): 郷充, 小島隆, 高野賢一, 氷見徹夫, 澤田典均.
  • Total Pages: 3
  • Publisher: 日本臨床分子形態学会編 学際企画