| Project/Area Number |
23590411
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Human pathology
|
|---|
| Research Institution | International University of Health and Welfare |
|---|
Principal Investigator |
AIDA Shinsuke 国際医療福祉大学, 大学病院, 教授 (10531387)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AIDA Junko 東京都健康長寿医療センター研究所, 老年病理学研究チーム高齢者がん, 研究員 (80425678)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | テロメア / 気管支上皮 / 喫煙 / 肺癌 / Q-FISH / FISH / 前癌病変 / p53 / Ki67 |
|---|
| Research Abstract |
Telomere lengths of the bronchial epithelium of 72 non-lung cancer adult autopsy cases and 24 surgically resected cases of lung squamous cell carcinoma were measured using Q-FISH method, and were expressed in normalized telomere:centromere ratios (NTCRs). The autopsied individuals included 27 current smokers (CuS), 33 never-smokers (NeS), 8 ex-smokers (ExS), and 4 unknown cases. The NTCRs of CuS, NeS and ExS were 1.515, 1.372 and 1.204, respectively. The bronchial epithelial telomeres of CuS were significantly longer than those of non-current smokers (NeS+ExS). The NTCRs of the bronchial epithelium of lung cancer cases and lung cancer tissue are 1.514 and 1.385, respectively. Our findings suggest that smoking causes telomeric elongation in the bronchial epithelium. The mechanism of carcinogenesis in smoking-related carcinomas is suggested to differ from that of many other carcinomas in which genetic instability due to aging-related telomeric shortening is considered to play a role.
|
