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The role of Mastermind in B-cell lymphoma

Research Project

Project/Area Number 23590413
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionSaitama Medical University

Principal Investigator

HIGASHI Morihiro  埼玉医科大学, 医学部, 講師 (00323395)

Co-Investigator(Kenkyū-buntansha) TAMARU Jun-ichi  埼玉医科大学, 医学部, 教授 (30188429)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords血液 / B細胞性リンパ腫 / Mastermind / Notch / 悪性リンパ腫 / 腫瘍発生機構 / LR11 / Notchシグナル / 免疫組織化学 / Matermind
Research Abstract

Mastermind (Mam) is a pivotal modulator of Notch signaling and has essential roles in the differentiation of B-cells from GC to MZ. We showed that 1) MamL1 and MamL3 were expressed in the GC and MZ of reactive lymph node. 2) Mam was expressed in 50% of cases with MC subtype of the Hodgkin lymphoma, whereas the expression was low in the cases with NS subtype. 3) Mam was expressed in the cases with follicular lymphoma and was low in the cases with marginal zone lymphoma. 4) The expression of Hes-1 was correlated with the expression of Notch1 or Jag2 in lymphoma cell lines, suggesting the Notch pathway is activated by cell-autonomously within lymphoma cell lines. 5) The expression of Hes-1 was correlated with LR11 expression. LR11 may be activated in parallel with Notch activation. Further investigation of the expression of Notch related molecules and the status of Notch activation is needed to clarify the biological and pathological differences in B-cell lymphomas originated from the GC.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 2 results) Presentation (6 results) Book (1 results)

  • [Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma2014

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C
    • Journal Title

      Leuk Lymphoma

      Volume: (印刷中) Issue: 10 Pages: 2391-2394

    • DOI

      10.3109/10428194.2014.880430

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow2014

    • Author(s)
      Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H
    • Journal Title

      Ann Hematol

      Volume: (印刷中) Issue: 7 Pages: 1111-1122

    • DOI

      10.1007/s00277-014-2033-0

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] G-CSF induces the release of the soluble form of LR11, a regulator of myeloid cell mobilization in bone marrow.2014

    • Author(s)
      Shimizu N, Nakaseko C, Jiang M, Nishii K, Yokote K, Iseki T, Higashi M, Tamaru J, Schneider WJ, Bujo H.
    • Journal Title

      Ann Hematol.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Potential utility of serum soluble LR11 as a diagnostic biomarker for intravascular large B-cell lymphoma.2014

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Higashi M, Fujikawa K, Matsue K, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume: 163(2) Issue: 2 Pages: 277-280

    • DOI

      10.1111/bjh.12467

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL2012

    • Author(s)
      Kanemitsu N, Isobe Y, Masuda A, Momose S, Higashi M, Tamaru J, Sugimoto K, Komatsu N
    • Journal Title

      Clin Cancer Res.

      Volume: 18(8) Pages: 2164-72

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tumor promoting effect of podoplanin-positive fibroblasts is mediated by enhanced RhoA activity.2012

    • Author(s)
      Ito S, Ishii G, Hoshino A, Hashimoto H, Neri S, Kuwata T, Higashi M, Nagai K, Ochiai A.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 442 Issue: 1 Pages: 194-9

    • DOI

      10.1016/j.bbrc.2012.04.158

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of Epstein-Barr Virus-Encoded Proteins in Extranodal NK/T-cell Lymphoma, Nasal Type (ENKL): Differences in Biologic and Clinical Behaviors of LMP1-Positive and -Negative ENKL.2012

    • Author(s)
      Kanemitsu N,
    • Journal Title

      Clin Cancer Res.

      Volume: 18(8) Issue: 8 Pages: 2164-2172

    • DOI

      10.1158/1078-0432.ccr-11-2395

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011

    • Author(s)
      Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, et. al
    • Journal Title

      Am J Surg Pathol

      Volume: 35(12) Pages: 1812-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【分子病態からみた血液疾患診療の進歩】ホジキンリンパ腫の病態解析の新展開2011

    • Author(s)
      東守洋,田丸淳一
    • Journal Title

      血液内科

      Volume: 62巻4号 Pages: 448-454

    • Related Report
      2013 Final Research Report
  • [Journal Article] Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas2011

    • Author(s)
      Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, Kobayashi M, Shimizu M, Ban S, Koyama I, Higashi M, et. al.
    • Journal Title

      Am J Surg Pathol.

      Volume: 35(12) Pages: 1812-7

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 【分子病態からみた血液疾患診療の進歩】 ホジキンリンパ腫の病態解析の新展開2011

    • Author(s)
      東 守洋, 田丸淳一
    • Journal Title

      血液内科

      Volume: 62巻4号 Pages: 448-454

    • Related Report
      2011 Research-status Report
  • [Presentation] LR11: implications for molecular targeting therapy in lymphoma2013

    • Author(s)
      Morihiro Higashi, Michihide Tokuhira, Takeharu Kawaguchi, Masahiro Takeuchi, Chikako Ohwada, Chiaki Nakaseko, Toshiki Watanabe, Hideaki Bujo, Masahiro Kizaki, Jun-ichi Tmaru
    • Organizer
      2nd Joint Scientific Meeting Medical University of Vienna and Chiba University
    • Place of Presentation
      ウィーン,オーストリア
    • Year and Date
      2013-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 悪性リンパ腫におけるLR11発現と意義2012

    • Author(s)
      東守洋, 得平道英, 川口岳晴, 竹内正博, 大和田千佳子, 中世古知明, 武成英明, 木崎昌弘, 田丸淳一
    • Organizer
      悪性リンパ腫治療研究会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-03
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Expression of LR11 in malignant lymphoma2011

    • Author(s)
      東守洋, 得平道英, 川口岳晴, 竹内正博, 大和田千佳子, 中世古知明, 武成英明, 木崎昌弘, 田丸淳一
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-15
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] LR11 repressed Rituximab Cytotoxity in B-cell lymphoma.

    • Author(s)
      東 守洋、得平道英、川口岳晴、武内正博、大和田千佳子、中世古知明、武城英明、木崎昌弘、田丸淳一
    • Organizer
      第75回日本血液学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 悪性リンパ腫におけるLR11発現とその意義

    • Author(s)
      東守洋, 得平道英, 川口岳晴, 武内正博, 大和田千佳子, 中世古知昭, 渡邊俊樹, 武城英明, 木崎昌弘, 田丸淳一
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京、新宿、京王プラザホテル
    • Related Report
      2012 Research-status Report
  • [Presentation] LR11 Expression in Malignant Lymphoma

    • Author(s)
      Morihiro Higashi, Michihide Tokuhira, Takeharu Kawaguchi, Masahiro Takeuchi, Chikako Ohwada, Chiaki Nakaseko, Toshiki Watanabe, Hideaki Bujo, Masahiro Kizaki, Jun-ichi Tmaru.
    • Organizer
      The 3rd JSH International Symposium 2012 in Kawagoe
    • Place of Presentation
      Prince Hotel Kawagoe, Kawagoe, Saitama
    • Related Report
      2012 Research-status Report
  • [Book] 造血器腫瘍とエピジェネティクス -治療への応用と新たな展開-2012

    • Author(s)
      東 守洋、田丸淳一 (木崎昌弘 編)
    • Total Pages
      10
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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