Exhaustive study for aquisition of eary diagnostic or the anti-cancer drug sensitivity markers for lung cancer
| Project/Area Number |
23590414
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
SATO Yuichi 北里大学, 医療衛生学部, 教授 (30178793)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肺癌 / 抗癌剤感受性予測 / 早期診断 / 単クローン性抗体 / 自己抗体 / 血清 |
|---|
| Research Abstract |
Erom established monoclonal antibodies for lung cancder, I selected useful early sero-diagnostic markers. As a results, anti-CAXII antibody was reported as asero-diagnostic marker (PLOS ONE 7(3): e33952, 2012). In addition, I submitted that antiBSG and MHY9 antibodies were useful markeres for pathological diagnosis of lung cancer. Ant-IMMT antibody was established as a sensitivity prediction marker of the platinum.
By the analysis of tumor-associated autoantibodies, I reported antiHu-C, Hu-D autoantibodies were novel differential sero-diagnostic markers for small cell lung carcinoma from large cell neuroendocrine carcinoma (Int J Oncol 40: 1957-1962, 2012).Ant-Galectin-3 autoantibody was found as an anticancer drug sensitivity prediction marker. And, I reported methodology that aquisition of useful sero-diagnostic autoantibodies using the same patients' sera and tumor tissues (Biomed Res 35(2): 133-143, 2014.
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Report
(4 results)
Research Products
(108 results)
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[Journal Article] Acquisition of useful sero-diagnostic autoantibodies using the same patients’sera and tumor tissues2014
Author(s)
Kobyashi M,Nagashio R, Ryuge S, Murakami Y, Yanagita K, Nakashima H, Matsumoto T, Jiang SX, Saegusa M, Satoh Y, Masuda N, Sato Y.
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Journal Title
Biomedical Research
Volume: 35
Issue: 2
Pages: 133-143
DOI
NAID
ISSN
0388-6107, 1880-313X
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical value of dividing false positive urine cytology findings into three categories: atypical, indeterminate, and suspicious of malignancy.2014
Author(s)
Matsumoto K, Ikeda M, Hirayama T, Nishi M, Fujita T, Hattori M, Sato Y, Ohbu M, Iwamura M.
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Journal Title
Asian Pac J Cancer Prev
Volume: 15 (5)
Issue: 5
Pages: 2251-2255
DOI
Related Report
Peer Reviewed
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[Journal Article] Incidence and clinical significance of abberrant T-cell marker expression on diffuse large B-cell lymphoma cells.2013
Author(s)
Suzuki Y, Yoshida T, Wang G, Aoki T, Katayama T, Miyamoto S, Miyazaki K, Iwabuchi K, Danbara M, Nakayama M, Horie R, Nakamine H, Sato Y, Nakamura N, Niitsu N.
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Journal Title
Acta Hematologica
Volume: 130
Issue: 4
Pages: 230-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Integrated view of the human chromosome X-centric proteome project.2013
Author(s)
Yamamoto T, Nakayama K, Hirano H, Tomonaga T, Ishihama Y, Yamada T, Kondo T,Kodera Y, Sato Y, Araki N, Mamitsuka H, Goshima N.
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Journal Title
J Proteome Res.
Volume: 12
Issue: 1
Pages: 58-61
DOI
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of nestin in resected large cell neuroendocrine carcinoma of the lung.2012
Author(s)
Ryuge S, Sato Y, Jiang Shi-X, Wang G, Matsumoto T, Katone K, Inoue H, Iyoda A, Satoh Y, Yoshimura H, Masuda N.
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Journal Title
Lung Cancer
Volume: 77(2)
Issue: 2
Pages: 415-420
DOI
Related Report
Peer Reviewed
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[Journal Article] Association of CD20 levels with clinicopathological parameters and its prognostic significance for patients with DLBCL2012
Author(s)
Suzuki Y, Yoshida T, Wang G, Togano T, Miyamoto S, Miyazaki K, Iwabuchi K, Nakayama M, Horie R, Niitsu N, Sato Y, Nakamura N
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Journal Title
Ann Hematol
Volume: 91(7)
Issue: 7
Pages: 997-1005
DOI
Related Report
Peer Reviewed
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[Presentation] Diagnostic significance of MUC5B and TTF-1 expression in resected non-small cell lung cancer.
Author(s)
Nagashio R, Ueda J, Kobayashi M, Yanagita K,Ryuge S, Katono K, Nakashima H, Jiang SX, Satoh Y, Masuda N, Murakumo Y, Sato Y.
Organizer
HUPO 12th Annual World Congress
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Related Report
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[Presentation] Detection of clinical validation of circulating autoantibodies as a useful sero-diagnostic markers for non-small cell lung cancer.
Author(s)
Kobayashi M, Nagashio R, Ryuge S, Nakashima H, Yanagita K, Tsuchiya B, Jiang SX, Saegusa M, Satoh Y, Masuda N, Sato Y.
Organizer
HUPO 12th Annual World Congress
Place of Presentation
パシフィコ横浜（神奈川県横浜市）
Related Report
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[Book] Change in expression of O6-methylguanine-DNA methyltransferase (MGMT) following chemotherapy for malignant glioma. Glioblastoma: Risk factors, Diagnosis and Treatment Options, Cancer Etiology, Diagnosis Treatments, Editors: Marcelo F. Bezerra and ClaudioR.2012
Author(s)
Utsuki S, Oka H, Kijima C, Miyajima Y, Fujii K, Matsumoto T, Sato Y.
Total Pages
10
Publisher
Nova Scientific Publishers
Related Report
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