| Project/Area Number |
23590415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Sox遺伝子 / 細胞増殖 / β-カテニン遺伝子 / TCF4遺伝子 / 子宮内膜癌 / Sox4 / Sox7 / Sox9 / β-カテニン / NF-κB / 子宮癌肉腫 / Sox４ / TCF4 |
|---|
| Research Abstract |
In endometrial carcinoma (EmCa) cells, Sox4 could enhance beta-catenin/TCF4 transcription, through up-regulation of TCF4 at the transcription level, without any direct beta-catenin association. Cells stably overexpressing Sox4 showed significant decreases in proliferation rate, along with increases in expression of p21waf1, in contrast to increased cell growth observed with knockdown. Sox7 could transcriptionally up-regulate Sox4 expression. Finally, Sox4 immunoreactivity was frequently pronounced in morules of Em Cas, the expression being positively correlated with status of beta-catenin, TCF4, and Sox7, and inversely with cell proliferation. These data therefore suggest that Sox4 may serve as a positive regulator of beta-catenin signaling through alteration in TCF4 expression during morular differentiation of Em Ca cells, leading to inhibition of cell proliferation.
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