Pathological Analysis for the Mechanisms of Malignant Transformation and Cancer Progression in Salivary Gland Tumor
Project/Area Number |
23590416
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
|
Research Institution | Tokyo Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
OSHIRO Hisashi 東京医科大学, 医学部, 講師 (60381513)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 唾液腺 / 癌 / 病理学 / 悪性化 / 免疫組織化学 / 遺伝子 / 発癌機構 |
Research Abstract |
To clarify the mechanisms of malignant transformation in salivary gland tumor, pathological analysis has been performed on carcinoma ex pleomorphic adenoma (PA) cases. Histologically, salivary duct carcinoma (SDC) was the most common malignant component of carcinoma ex PA. In the early stage of development, carcinoma cells proliferated replacing by ductal structures of pre-existing PA. Immunohistochemical study revealed that carcinoma component had high proliferative activities and was positive for p53 and HER2 in a half of the cases. Molecular analysis demonstrated the LOH at p53 microsatellite loci, accompanied by p53 gene point mutation, only in the carcinoma component, but no genetic alterations have been detected in the H-, K-, and N-ras genes. Furthermore AR, HER2, and EGFR were positive in 75%, 44%, and 81% of 32 SDC cases, respectively. In addition, 2-year disease-free survival was significantly worse in AR- and EGFR-negative SDC cases.
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Report
(4 results)
Research Products
(190 results)
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[Journal Article] Clinicopathological significance of androgen receptor, HER2, Ki-67 and EGFR expression in salivary duct carcinoma2014
Author(s)
Masubuchi T, Tada Y, Maruya SI, Osamura Y, Kamata SE, Miura K, Fushimi C, Takahashi H, Kawakita D, Kishimoto S, Nagao T
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Int J Clin Oncol
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[Journal Article] Establishment of successively transplantable rabbit VX2 cancer cells that express enhanced green fluorescent protein2014
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Oshiro H, Fukumura H, Nagahama K, Sato I, Sugiura K, Iobe H, Okiyama E, Nagao T, Nagashima Y, Aoki I, Yamanaka S, Murakami A, Maegawa J, Chishima T, Ichikawa Y, Ishikawa Y, Nagai T, Nomura M, Ohashi K, Okudela K
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Med Mol Molphol
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[Journal Article] A proposal for combination of total number and anatomical location of involved lymph nodes for nodal classification in non-small cell lung cancer2013
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Saji H, Tsuboi M, Shimada Y, Kato Y, Yoshida K, Nomura M, Matsubayashi J, Nagao T, Kakihana M, Usuda J, Kajiwara N, Ohira T, Ikeda N
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Chest
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Placenta.
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[Journal Article] A case of paravertebral mediastinal chordoma without bone destruction.2012
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Matsubayashi J, Sato E, Nomura M, Kakihana M, Uchida O, Saji H, Park J, Akata S, Ikeda N, Nagao T, Ishida T.
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Lung Cancer
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NAID
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[Journal Article] Immunohistochemical Analysis of Salivary Gland Tumors: Application for Surgical Pathology Practice2012
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Nagao T, Sato E, Inoue R, Oshiro H, Takahashi RH, Nagai T, Yoshida M, Suzuki F, Obikane H, Yamashina M, Matsubayashi J.
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ACTA HISTOCHEMICA ET CYTOCHEMICA
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Issue: 5
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NAID
ISSN
0044-5991, 1347-5800
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Invest Ophthalmol Vis Sci
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[Journal Article] Narrow-band imaging on screening of esophageal lesions using an ultrathin transnasal endoscopy.2012
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Kawai T, Takagi Y, Yamamoto K, Hayama Y, Fukuzawa M, Yagi K, Fukuzawa M, Kataoka M, Kawakami K, Itoi T, Moriyasu F, Matsubayashi J, Nagao T.
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J Gastroenterol Hepatol
Volume: 27
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[Journal Article] Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver.2012
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Itoi T, Isayama H, Sofuni A, Itokawa F, Tamura M, Watanabe Y, Moriyasu F, Kahaleh M, Habib N, Nagao T, Yokoyama T, Kasuya K, Kawakami H.
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[Journal Article] Narrow-band imaging on screening of esophageal lesions using an ultrathin transnasal endoscopy2012
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J Gastroenterol Hepatol
Volume: Suppl 3
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[Journal Article] Evaluation of effects of a novel endoscopically applied radiofrequency ablation biliary catheter using an ex-vivo pig liver2012
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Itoi T, Isayama H, Sofuni A, Itokawa F, Tamura M, Watanabe Y, Moriyasu F, Kahaleh M, Habib N, Nagao T, Yokoyama T, Kasuya K, Kawakami H.
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J Hepatobiliary Pancreat Sci
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[Journal Article] EGFR protein expression in non-small cell lung cancer predicts response to an EGFR tyrosine kinase inhibitor - A novel antibody for immunohistochemistry or AQUA technology2011
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Mascaux C, Wynes MW, Kato Y, Tran C, Reyna Asuncion B, Zhao J, Gustavson M, Ranger-Moore J, Gaire F, Matsubayashi J, Nagao T, Yoshida K, Ohira T, Ikeda N, Hirsch FR.
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[Journal Article] Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study2011
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粕谷和彦, 糸井隆夫, 土田明彦, 永川裕一, 中島哲史, 松土尊映, 池田隆久, 鈴木芳明, 祖父尼淳, 松林純, 長尾俊孝, 青木達哉
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[Presentation] 多施設共同による唾液腺導管癌の後方視的観察研究 導管癌および多形腺腫由来導管癌の臨床像2013
Author(s)
清水 顕, 伊藤 博之, 高瀬 聡一郎, 鈴木 衞, 長尾 俊孝, 今西 順久, 大塚 邦憲, 多田 雄一郎, 加納 里志, 花澤 豊行, 茶園 英明
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[Presentation] 胆膵悪性腫瘍におけるp53蛋白過剰発現と血清抗p53抗体陽性率の比較2011
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梅田純子,糸井隆夫, 祖父尼淳, 糸川文英, 土屋貴愛, 栗原俊夫, 辻修二郎, 石井健太郎, 池内信人, 田中麗奈, 殿塚亮祐, 森安史典, 大城久, 長尾俊孝
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[Presentation] 多施設共同による唾液腺導管癌の後方視的観察研究 生存率および予後因子に関する検討
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第36回日本頭頸部癌学会
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多田 雄一郎, 花澤 豊行, 今西 順久, 佐藤 雄一郎, 金澤 丈治, 福島 啓文, 清水 顕, 加納 里志, 矢島 陽子, 大上 研二, 長尾 俊孝
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第36回日本頭頸部癌学会
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