| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We made an antibody against HRF to elucidate mechanism for allergic diseases such as a rheumatic arthritis (RA) and controlled the development after the injection of antibody to RA model mice. It is still unclear the correlation with between HRF and RA. To study the association between HRF and allergy, we tried to make RA mouse and atopic dermatitis (AD) mouse. In RA and AD model mice, cellular infiltrations were found as lymphocytes and macrophages and mast cells in the inflammatory region. In these animals IgE and histamine productions decreased. We analyzed the property of the HRF antibody to examine the expression of HRF with the model mice. These results showed the possibility that it could become the materials which examined the correlation between the allergic disease with HRF.
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