Relationship between Histamine releasing Factor and rheumatoid arthritis
Project/Area Number |
23590417
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Tokyo Medical University |
Principal Investigator |
ISHIKAWA Akio 東京医科大学, 医学部, 助手 (80468652)
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Co-Investigator(Kenkyū-buntansha) |
TAKANASHI Masakatsu 東京医科大学, 医学部, 講師 (80312007)
SUDO Katsuko 東京医科大学, 医学部, 兼任講師 (50126091)
UEDA Shinobu 東京医科大学, 医学部, 助手 (00521874)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | HRF / リウマチ関節炎 / ヒスタミン / 炎症 / 関節炎 |
Research Abstract |
We made an antibody against HRF to elucidate mechanism for allergic diseases such as a rheumatic arthritis (RA) and controlled the development after the injection of antibody to RA model mice. It is still unclear the correlation with between HRF and RA. To study the association between HRF and allergy, we tried to make RA mouse and atopic dermatitis (AD) mouse. In RA and AD model mice, cellular infiltrations were found as lymphocytes and macrophages and mast cells in the inflammatory region. In these animals IgE and histamine productions decreased. We analyzed the property of the HRF antibody to examine the expression of HRF with the model mice. These results showed the possibility that it could become the materials which examined the correlation between the allergic disease with HRF.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] TLS-CHOP represses miR-486 expression, inducing upregulation of a metastasis regulator PAI-1 in human myxoid liposarcoma2012
Author(s)
N. Borjigin, S. Ohno, W. Wu, M. Tanaka, R. Suzuki, K. Fujita, M. Takanashi, K. Oikawa, T. Goto, T. Motoi, T. Kosaka, K. Yamamoto, M. Kuroda
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 427
Issue: 2
Pages: 355-360
DOI
Related Report
Peer Reviewed
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[Presentation]2012
Author(s)
高梨正勝, 須藤カツ子, 松永芳径, 大木忠明, 濱崎智洋, 谷口維紹, 臼井嘉彦, 後藤浩, 黒田雅彦
Organizer
第32回日本眼薬理学会総会
Place of Presentation
滋賀
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