Histogenesis and differentiatiion of soft tissue sarcomas

• Project/Area Number: 23590419
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Fukuoka University
• Principal Investigator: IWASAKI Hiroshi 福岡大学, 医学部, 教授 (90101170)
• Co-Investigator(Renkei-kenkyūsha): JIMI Shirou 福岡大学, 医学部, 講師 (30226360)
• Research Collaborator: AOKI Mikiko 福岡大学, 医学部, 助教 (80469379) ; ISHIGURO Masako 福岡大学, 医学部, 病理学研究員
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 軟部組織腫瘍 / 肉腫 / 遺伝子検索 / 染色体異常 / 骨髄幹細胞 / 間葉系幹細胞 / 腫瘍 / 融合遺伝子 / sarcoma / liposarcoma / histogenesis / mesenchymal stem cell / soft tissue tumors / 骨軟部腫瘍 / 腫瘍幹細胞 / 染色体分析 / 骨・軟部腫瘍

Outline of Final Research Achievements

1. Lipoma-like myxoid type liposarcoma and well-differentiated liposarcoma exhibited a similar histology, but different cytogenetic profiles. The former possessed specific t (12; 16) and FUS-DDIT3, whereas the latter was characterized by giant marker and supernumerary ring chromosomes.
2. The monoclonal antibody FU3 against undifferentiated pleomorphic sarcoma reacted strongly with sarcoma cells and perivascular mesenchymal cells. The present study demonstrated that FU3 antigen is identical to CD13.
3. The bone marrow cells expressing GFP were transplanted into mice under bone marrow suppression. After administration of 3-methylcholanthrene subcutaneously, immature mesenchymal cells appeared around small blood vessels, then high-grade sarcoma developed. The sarcoma cells expressed GFP in approximately 1/4 of the mice. There are two possibilities concerning the origin of the sarcoma: bone marrow-derived mesenchymal stem cells, and resident mesenchymal cells of local soft tissues.

Research Products

• [Journal Article] Extensive lipoma-like changes of myxoid liposarcoma: morphologic, immunohistochemical, and molecular cytogenetic analyses. (2015)
  • Author(s): Iwasaki H, Ishiguro M, Nishio J, Aoki M, Yokoyama R, Yokoyama K, Taguchi K, Nabeshima K:
  • Journal Title: Virchows Arch Volume: 466 Issue: 4 Pages: 453-64
  • DOI: 10.1007/s00428-015-1721-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Collagenous fibroma (desmoplastic fibroblastoma) with trisomy 8 as the sole cytogenetic abnormality. (2013)
  • Author(s): Nishio J, Iwasaki H, Yano S, Naito M.
  • Journal Title: Anticancer Res Volume: 33 Pages: 3259-3262
  • Peer Reviewed
• [Journal Article] FDG PET/CT findings of superficial angiomyxoma. (2013)
  • Author(s): Nishio J1, Iwasaki H, Aoki M, Nabeshima K, Naito M.
  • Journal Title: Clin Nucl Med Volume: 39 Issue: 4 Pages: 367-370
  • DOI: 10.1097/rlu.0b013e3182995e15
  • Peer Reviewed
• [Journal Article] Scapular osteochondrolipoma: Imaging features with pathological correlation (2013)
  • Author(s): Nishio J, Ideta S, Iwasaki H, Naito M
  • Journal Title: Oncol Lett Volume: 6 Issue: 3 Pages: 817-820
  • DOI: 10.3892/ol.2013.1455
  • Peer Reviewed
• [Journal Article] 子宮頸部原発横紋筋肉腫の1例 (2013)
  • Author(s): 今城有芸、廣田智子、阿南春分、中村寿美得、白橋浄彦、高橋庸子、近藤晴彦、植田多惠子、宮本新吾、宮川三代子、青木光希子、岩崎宏
  • Journal Title: 福岡産婦人科学会雑誌 Volume: 36 Pages: 3-8
  • Peer Reviewed
• [Journal Article] Characterization of giant marker and ring chromosomes in a pleomorphic leiomyosarcoma of soft tissue by spectral karyotyping. (2012)
  • Author(s): Nishio, J., Aoki, M., Nabeshima, K., Iwasaki, H., Naito, M.
  • Journal Title: Oncol Rep Volume: 28 Issue: 2 Pages: 533-538
  • DOI: 10.3892/or.2012.1835
  • Peer Reviewed
• [Journal Article] Low-grade central osteosarcoma of the metatarsal bone: a clinicopathological, immunohistochemical, cytogenetic and molecular cytogenetic analysis. (2012)
  • Author(s): Nishio, J., Iwasaki, H., Takagi, S., Seo, H., Aoki, M., Nabeshima, K., Naito, M.
  • Journal Title: Anticancer Res Volume: 32 Pages: 5429-5435
  • Peer Reviewed
• [Journal Article] EWS-WT1 Chimeric Protein in Desmoplastic Small Round Cell Tumor is a Potent Transactivator of FGFR4. (2012)
  • Author(s): Saito, T., Yokotsuka, M., Motoi, T., Iwasaki, H., Nagao, T., Marc Ladanyi, M., Yao, T.
  • Journal Title: J Cancer Sci Ther Volume: 4 Issue: 10 Pages: 335-340
  • DOI: 10.4172/1948-5956.1000164
  • Peer Reviewed
• [Journal Article] Elastofibroma dorsi: diagnostic and therapeutic algorithm (2012)
  • Author(s): Nishio J, Isayama T, Iwasaki H, Naito M
  • Journal Title: J Shoulder Elbow Surg Volume: 21 Issue: 1 Pages: 77-81
  • DOI: 10.1016/j.jse.2011.01.043
  • Peer Reviewed
• [Journal Article] Cytogenetic and molecular cytogenetic findings in giant dedifferentiated liposarcoma of the thigh (2012)
  • Author(s): Nishio J, Aoki M, Nabeshima K, Iwasaki H, Naito M
  • Journal Title: Oncology Rep Volume: 27 Pages: 764-768
  • DOI: 10.3892/or.2011.1584
  • Peer Reviewed
• [Journal Article] Myxoid liposarcoma of the ankle: a case report (2012)
  • Author(s): Nishio J, Isayama T, Yoshimura I, Ohjimi H, Iwasaki H, Naito M
  • Journal Title: J Foot Ankle Surg Volume: 51 Issue: 1 Pages: 76-79
  • DOI: 10.1053/j.jfas.2011.09.005
  • Peer Reviewed
• [Journal Article] いわゆる悪性線維性組織球腫 (2012)
  • Author(s): 岩崎 宏
  • Journal Title: 病理と臨床 Volume: 30 Pages: 280-228
  • Peer Reviewed
• [Journal Article] CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Mullerian tumor) (2011)
  • Author(s): Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, Iwasaki H, Emoto M
  • Journal Title: Stem Cells Volume: 29 Issue: 10 Pages: 1485-1495
  • DOI: 10.1002/stem.711
  • Peer Reviewed
• [Journal Article] Expression of laminin 5-Y2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion. (2011)
  • Author(s): Hamasaki H, Koga K, Aoki M, Hamasaki M, Koshikawa N, Seiki M, Iwasaki H, Nakayama J, Nabeshima K
  • Journal Title: Br J Cancer. Volume: 6;105(6) Issue: 6 Pages: 824-32
  • DOI: 10.1038/bjc.2011.283
  • Peer Reviewed
• [Journal Article] Cranial fasciitis resembling infantile fibrosarcoma differentiated by genetic assay (2011)
  • Author(s): Imafuku S, Takahashi A, Hashizumi Y, Sasamoto K, Tokumaru R, Iwasaki H, Nakayama J
  • Journal Title: J Dermatol Volume: 38 Issue: 10 Pages: 1006-1009
  • DOI: 10.1111/j.1346-8138.2010.01161.x
  • NAID: 10031147118
  • Peer Reviewed
• [Journal Article] Translocation t(2;11) is characteristic of collagenous fibroma (desmoplastic fibroblastoma) (2011)
  • Author(s): Nishio J, Akiho S, Iwasaki H, Naito M
  • Journal Title: Cancer Genet Volume: 204 Issue: 10 Pages: 569-571
  • DOI: 10.1016/j.cancergen.2011.10.003
  • Peer Reviewed
• [Book] 軟部腫瘍 (2011)
  • Author(s): 岩崎 宏（分担）
  • Total Pages: 267
  • Publisher: 文光堂