Research Project
Grant-in-Aid for Scientific Research (C)
We have demonstrated that Hsp90 can act as an efficient inducer for crosspresentation of associated antigenic peptide via spatiotemporal regulation. We examined whether vaccination with Hsp90-antigen peptide complex and TLR ligand augmented the induction of cytotoxic T cell (CTL) response via crosspresentation. Interestingly, plasmacytoid dendritic cells (pDCs) secreted not only IFN-a but also Hsp72 in response to CpG-A administration. We found that the secreted Hsp72 formed complex with Hsp90-peptide complex, leading to the efficient crosspresentation and CTL induction against associated peptide. These data suggest that CpG-A is a good candidate as an immunoadjuvant for Hsp90-based cancer vaccine.
All 2013 2012 2011 Other
All Journal Article Presentation Book Remarks
Pathol Int.
Volume: 63(8) Pages: 391-7
10.1111/pin.12079
Exp Cell Res.
Volume: 319 Pages: 2617-26
10.1016/j.yexcr.2013.07.025
Tissue Antigens
Volume: 81(6) Pages: 428-34
10.1111/tan.12113
Cancer Sci
Volume: 104 Pages: 1091-1096
10.1111/cas.12177
Anticancer Res.
Volume: 33 Pages: 167-173
Volume: 104 Pages: 124-129
10.1111/cas.12046
Exp Mol Pathol.
Volume: 94 Pages: 322-327
10.1016/j.yexmp.2012.10.004
Pathol Int
Volume: 62(10) Pages: 684-689
10.1111/j.1440-1827.2012.02851.x
Pathology International
Volume: 63 Pages: 391-397
Immunotherapy.
Volume: 8 Pages: 841-852
10.2217/imt.12.75
Curr Mol Med
Volume: 12 Pages: 1198-1206
Cell Stress Chaperones.
Volume: 17 Pages: 757-63
10.1007/s12192-012-0348-0
J Dermatol Sci.
Volume: 67 Pages: 51-60
10.1016/j.jdermsci.2012.04.009
Cancer Res,
Volume: (in press) Pages: 2844-54
10.1158/0008-5472.can-11-3062
Volume: 62 Pages: 303-8
10.1111/j.1440-1827.2012.02789.x
10031185205
Carcinogenesis
Volume: 33 Pages: 996-1003
10.1093/carcin/bgs118
Volume: 92 Pages: 27-32
10.1016/j.yexmp.2011.09.016
Curr Mol Med.
Lab Invest
Volume: 91 Pages: 1796-1804
10.1038/labinvest.2011.140
J.Immunol
Volume: 186 Pages: 4325-4230
10.4049/jimmunol.1004048
Int Immunol
Volume: 23 Pages: 223-237
10.1093/intimm/dxq475
Cancer Science
Volume: 102 Pages: 1181-1187
10.1111/j.1349-7006.2011.01918.x
10029294487
J Immunoassay Immunoch
Volume: 32 Pages: 93-102
10.1080/15321819.2010.543219
Am. J. Pathol
Volume: 178 Pages: 1805-1813
10.1016/j.ajpath.2011.01.004
http://web.sapmed.ac.jp/patho1/