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Development of clinical applications for cancer/stem-cell-associated molecules target therapy in head and neck cancer

Research Project

Project/Area Number 23590439
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionNational Center of Neurology and Psychiatry

Principal Investigator

MORI TAISUKE  独立行政法人国立がん研究センター, 中央病院, 医員 (00296708)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords診断病理学 / 頭頸部がん / 頭頸部腫瘍 / がん幹細胞 / 病理診断 / 診断マーカー
Research Abstract

I've been clear that the stem cell-associated molecules YBX1, Bmi1, HMGA2, and EpCAM are involved in the trait of head and neck cancer from the comprehensive analysis with a focus on related molecules in stem cells of head and neck squamous cell carcinoma.
In particular, I revealed that HMGA2 is a prognostic factor estimation and advanced cancer and that Bmi1 is a marker of early squamous cell carcinoma. Moreover,YBX1 is one of the causes of chemoradiation-resistant cancer was suggested.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 18 results,  Open Access: 1 results) Presentation (20 results) (of which Invited: 6 results) Book (1 results)

  • [Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.2014

    • Author(s)
      Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
    • Journal Title

      Int J Cancer.

      Volume: On line Issue: 3 Pages: 613-22

    • DOI

      10.1002/cam4.214

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stem cell self-renewal factors, Bmi1 and HMGA2 expressed in head and neck squamous cell carcinoma : Clues to the tumor characteristics for diagnosis2013

    • Author(s)
      Yamazaki H, Mori T, Yazawa M, Maeshima A, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y
    • Journal Title

      Lab. Invest.

      Volume: 93 Pages: 1331-1338

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors : A clue to the histogenesis for diagnosis2013

    • Author(s)
      Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima A, Akazawa C, WatabeY, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
    • Journal Title

      Mod Pathol.

      Volume: 26 Pages: 1041-50

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms2013

    • Author(s)
      Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y
    • Journal Title

      Br J Cancer

      Volume: 5;108 (4) Pages: 951-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Malignant Bone Treatments for Reuse2013

    • Author(s)
      Yazawa M, Mori T, Kishi K
    • Journal Title

      Surgical Science

      Volume: Vol. 4 No. 1 Pages: 49-52

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Hepatocellular Carcinoma Biomarker, Cyclase-Associated Protein 2 in Zebrafish Body Development and Cancer Progression2013

    • Author(s)
      Effendi K, Yamazaki K, Mori T, Masugi Y, Makino S, Sakamoto
    • Journal Title

      M Exp Cell Res.

      Volume: 1;319(1) Pages: 35-44

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma2013

    • Author(s)
      Sato Y, Ojima H, Onaya H, Mori T, Hiraoka N, Kishi Y, Nara S, Esaki M, Shimada K, Kosuge T, Sugihara K, Kanai Y
    • Journal Title

      Hepatol Res.

      Volume: 1;319(1) Pages: 35-44

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 早期口腔癌の病理組織像とその捉え方2013

    • Author(s)
      森泰昌
    • Journal Title

      口腔腫瘍学会雑誌

      Volume: 25巻第3号 Pages: 2-53

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔癌の早期診断とその分子病理学的理解2013

    • Author(s)
      森泰昌
    • Journal Title

      歯科学報

      Volume: 113(5) Pages: 495-499

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 招待講演大阪大学歯学部「口の難病プロジェクト」成果報告会特別講演2013

    • Author(s)
      森泰昌
    • Journal Title

      Stem cell biology to oral cancer biology

    • Related Report
      2013 Final Research Report
  • [Journal Article] Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis.2013

    • Author(s)
      Yamazaki H, Mori T, Yazawa M, Maeshima AM, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y.
    • Journal Title

      Lab Invest.

      Volume: Dec;93(12): Issue: 12 Pages: 1331-8

    • DOI

      10.1038/labinvest.2013.120

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis2013

    • Author(s)
      Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
    • Journal Title

      Modern Pathology

      Volume: Aug;26(8): Issue: 8 Pages: 1041-50

    • DOI

      10.1038/modpathol.2013.54

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of Hepatocellular Carcinoma Biomarker, Cyclase-Associated Protein 2 in Zebrafish Body Development and Cancer Progression2013

    • Author(s)
      Effendi K
    • Journal Title

      Exp Cell Res.

      Volume: 319 Issue: 1 Pages: 35-44

    • DOI

      10.1016/j.yexcr.2012.09.013

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 早期口腔癌の病理組織像とその捉え方2013

    • Author(s)
      森 泰昌
    • Journal Title

      口腔腫瘍学会雑誌

      Volume: 25-(3) Pages: 42-53

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells & fibroblasts for mammalian internal organs, and their vasculature2012

    • Author(s)
      Rinkevich Y, Mori T, Sahoo D, Xu P, Bermingham JR
    • Journal Title

      Weissman IL Nature Cell Biol.

      Volume: 14(12) Pages: 1251-60

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Hepatocellular Carcinoma Biomarker, Cyclase -Associated Protein 2 in Zebrafish Body Development and Cancer Progression2012

    • Author(s)
      Effendi K, Yamazaki K, Mori T, Masugi Y, Makino S, Sakamoto M
    • Journal Title

      Exp Cell Res

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas2012

    • Author(s)
      Arai E, Chiku S, Mori T, Gotoh M, Nakagawa T, Fujimoto H, Kanai Y
    • Journal Title

      Carcinogenesis

      Volume: 33(8) Pages: 1487-1493

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells & fibroblasts for mammalian internal organs, and their vasculature2012

    • Author(s)
      Rinkevich Y
    • Journal Title

      Nature Cell Biol.

      Volume: 14 Issue: 12 Pages: 1251-1260

    • DOI

      10.1038/ncb2610

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Single-CpG-resolution methylome analysis identifies clinicopathologically aggressive CpG island methylator phenotype clear cell renal cell carcinomas2012

    • Author(s)
      Arai E, Kanai Y et al.
    • Journal Title

      Carcinogenesis

      Volume: 33 Issue: 8 Pages: 1487

    • DOI

      10.1093/carcin/bgs177

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification by Differential Tissue Proteome Analysis of Talin-1 as a Novel Molecular Marker of Progression of Hepatocellular Carcinoma2011

    • Author(s)
      Kanamori H, Kawakami T, Effendi K, Yamazaki K, Mori T, Ebinuma H, Masugi Y, Du W, Nagasaka K, Ogiwara A, Kyono Y, Tanabe M, Saito H, Hibi T, Sakamoto M
    • Journal Title

      Oncology

      Pages: 406-415

    • Related Report
      2013 Final Research Report
  • [Journal Article] 病理診断に役立つ分子生物学病理診断医になじみのある疾患関連分子解説編2011

    • Author(s)
      森泰昌
    • Journal Title

      病理と臨床臨時増刊号

      Volume: Vol 29 Pages: 380-383

    • Related Report
      2013 Final Research Report
  • [Journal Article] 胆管形質を示す肝細胞癌の臨床と分子生物学肝細胞癌における胆管形質の発現:肝ステム細胞の意義2011

    • Author(s)
      森泰昌, 尾島英知, 坂元亨宇
    • Journal Title

      肝胆膵

      Volume: Vol. 63 No4

    • Related Report
      2013 Final Research Report
  • [Journal Article] 肝癌の多段階発癌過程と肝癌幹細胞を探る分子消化器病2011

    • Author(s)
      森泰昌, 坂元亨宇
    • Volume
      vol8, no1
    • Pages
      28-32
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部における稀少がんの病理2014

    • Author(s)
      森泰昌
    • Organizer
      第59回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2014-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期口腔癌に対する新たな診断法の確立2014

    • Author(s)
      森泰昌
    • Organizer
      第63回日本病理学会関東支部会総会
    • Place of Presentation
      東京
    • Year and Date
      2014-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭頸部扁平上皮癌における治療方針の決定に有用なバイオマーカー2014

    • Author(s)
      森泰昌
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Year and Date
      2014-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム「頭頸部における稀少がんの病理」2014

    • Author(s)
      森 泰昌
    • Organizer
      第59回日本口腔外科学会総会
    • Place of Presentation
      千葉 幕張
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] レクチャー「早期口腔癌に対する新たな診断法の確立」2014

    • Author(s)
      森 泰昌
    • Organizer
      第63回日本病理学会関東支部会総会
    • Place of Presentation
      昭和大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 頭頸部扁平上皮癌における治療方針の決定に有効なバイオマーカーの探索2014

    • Author(s)
      森 泰昌
    • Organizer
      第103回 日本病理学会総会
    • Place of Presentation
      広島 広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] 唾液腺腫瘍の階層的クラスタリング解析によるグループ分類とそれらを規程するマーカー2013

    • Author(s)
      森泰昌
    • Organizer
      第24回日本臨床口腔病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌の診断と治療戦略2013

    • Author(s)
      森泰昌
    • Organizer
      第67回日本口腔科学会学術総会
    • Place of Presentation
      宇都宮栃木
    • Year and Date
      2013-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 早期口腔癌の病理像とその捉え方2013

    • Author(s)
      森泰昌
    • Organizer
      第31回日本口腔腫瘍学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-01-24
    • Related Report
      2013 Final Research Report
  • [Presentation] シンポジウム口腔癌の診断と治療戦略:基礎そして臨床から―口腔癌の先端研究に基づいた近未来的治療戦略について2013

    • Author(s)
      森 泰昌
    • Organizer
      第67回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      栃木 宇都宮
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 唾液腺腫瘍の階層的クラスタリング解析によるグループ分類とそれらを規程するマーカー2013

    • Author(s)
      森 泰昌
    • Organizer
      第24回 日本臨床口腔病理学会総会
    • Place of Presentation
      日本大学歯学部
    • Related Report
      2013 Annual Research Report
  • [Presentation] 早期口腔癌の病理組織像とその捉え方2013

    • Author(s)
      森 泰昌
    • Organizer
      第31回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 幹細胞関連分子の発現する頭頸部扁平上皮癌の特性とその予後2012

    • Author(s)
      森泰昌
    • Organizer
      第23回日本臨床口腔病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌の悪性形質の発現に関する橋渡し研究と分子標的治療の応用2012

    • Author(s)
      森泰昌
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumor2012

    • Author(s)
      Ohtomo R, Mori T et al.
    • Organizer
      101 st Annual meeting The united states and Canadian academy of pathology
    • Place of Presentation
      バンクーバー, カナダ
    • Year and Date
      2012-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 口腔癌の悪性形質の発現に関する橋渡し研究と分子標的治療への応用2012

    • Author(s)
      森 泰昌
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 幹細胞関連分子の発現する頭頸部扁平上皮癌の特性とその予後2012

    • Author(s)
      森 泰昌
    • Organizer
      第23回日本臨床口腔病理学会総会・学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors2012

    • Author(s)
      Rie Ohtomo, Taisuke Mori, Koji Tsuta, Akiko M. Maeshima, Seiichi Yoshimoto, Masao Asai, Hitoshi Tsuda.
    • Organizer
      101st ANNUAL MEETING The United States and Canadian Academy of Pathology
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2012 Research-status Report
  • [Presentation] がんと幹細胞に共通する機構の解明を目的とした網羅的な蛋白質間相互作用解析を用いたキー因子の探索2011

    • Author(s)
      森泰昌
    • Organizer
      第34回日本分子生物学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] がんと幹細胞に共通する機構の解明を目的とした網羅的なタンパク質間相互作用解析をキー因子の探索2011

    • Author(s)
      森 泰昌
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川、横浜(パシフィコ横浜)
    • Related Report
      2011 Research-status Report
  • [Book] スタンダード病理学2014

    • Author(s)
      森泰昌他(分担執筆)
    • Publisher
      文光堂(東京)(in press)
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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