Development of clinical applications for cancer/stem-cell-associated molecules target therapy in head and neck cancer
Project/Area Number |
23590439
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | National Center of Neurology and Psychiatry |
Principal Investigator |
MORI TAISUKE 独立行政法人国立がん研究センター, 中央病院, 医員 (00296708)
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | 診断病理学 / 頭頸部がん / 頭頸部腫瘍 / がん幹細胞 / 病理診断 / 診断マーカー |
Research Abstract |
I've been clear that the stem cell-associated molecules YBX1, Bmi1, HMGA2, and EpCAM are involved in the trait of head and neck cancer from the comprehensive analysis with a focus on related molecules in stem cells of head and neck squamous cell carcinoma. In particular, I revealed that HMGA2 is a prognostic factor estimation and advanced cancer and that Bmi1 is a marker of early squamous cell carcinoma. Moreover,YBX1 is one of the causes of chemoradiation-resistant cancer was suggested.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome.2014
Author(s)
Arai E, Sakamoto H, Ichikawa H, Totsuka H, Chiku S, Gotoh M, Mori T, Nakatani T, Ohnami S, Nakagawa T, Fujimoto H, Wang L, Aburatani H, Yoshida T, Kanai Y.
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Journal Title
Int J Cancer.
Volume: On line
Issue: 3
Pages: 613-22
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Stem cell self-renewal factors, Bmi1 and HMGA2 expressed in head and neck squamous cell carcinoma : Clues to the tumor characteristics for diagnosis2013
Author(s)
Yamazaki H, Mori T, Yazawa M, Maeshima A, Matsumoto F, Yoshimoto S, Ota Y, Kaneko A, Tsuda H, Kanai Y
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Journal Title
Lab. Invest.
Volume: 93
Pages: 1331-1338
Related Report
Peer Reviewed
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[Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors : A clue to the histogenesis for diagnosis2013
Author(s)
Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima A, Akazawa C, WatabeY, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
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Journal Title
Mod Pathol.
Volume: 26
Pages: 1041-50
Related Report
Peer Reviewed
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[Journal Article] Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms2013
Author(s)
Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y
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Journal Title
Br J Cancer
Volume: 5;108 (4)
Pages: 951-8
Related Report
Peer Reviewed
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[Journal Article] Histopathological characteristics of hypervascular cholangiocellular carcinoma as an early stage of cholangiocellular carcinoma2013
Author(s)
Sato Y, Ojima H, Onaya H, Mori T, Hiraoka N, Kishi Y, Nara S, Esaki M, Shimada K, Kosuge T, Sugihara K, Kanai Y
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Journal Title
Hepatol Res.
Volume: 1;319(1)
Pages: 35-44
Related Report
Peer Reviewed
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[Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis2013
Author(s)
Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
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Journal Title
Modern Pathology
Volume: Aug;26(8):
Issue: 8
Pages: 1041-50
DOI
Related Report
Peer Reviewed
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[Journal Article] Identification by Differential Tissue Proteome Analysis of Talin-1 as a Novel Molecular Marker of Progression of Hepatocellular Carcinoma2011
Author(s)
Kanamori H, Kawakami T, Effendi K, Yamazaki K, Mori T, Ebinuma H, Masugi Y, Du W, Nagasaka K, Ogiwara A, Kyono Y, Tanabe M, Saito H, Hibi T, Sakamoto M
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Journal Title
Related Report
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