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The effect of EB virus infection in nasopharyngeal carsinoma cancer stem cell

Research Project

Project/Area Number 23590443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionHokkaido University

Principal Investigator

IIZASA Hisashi  北海道大学, 遺伝子病制御研究所, 助教 (80306662)

Co-Investigator(Renkei-kenkyūsha) IWAKIRI Dai  北海道大学, 遺伝子病制御研究所, 助教 (10307853)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsがん幹細胞 / EBウイルス / SOX2 / プロモーター / 幹細胞 / EBウィルス
Research Abstract

We had tried to establish EB virus (EBV) negative cell lines from EBV harboring human nasopharyngeal carcinoma cell line C666-1. C666-1 had a large number of EBV copies per cell and we could not establish EBV negative cell line from C666-1 using drug treatment and dilution cloning. These results suggest that EBV infection is essential to keep C666-1 cell proliferation. Next, to isolate cancer stem cell population from nasopharyngeal carcinoma, we analyzed the expression mechanism of stem cell specific transcription factor SOX2 in cancer cell lines. SOX2 promoter activity was related to SOX2 mRNA expression level and promoter positive cell population showed high sphere activity. Moreover, we identified SOX2 promoter binding protein and this protein regulated cancer stem cell formation by the regulation of SOX2 promoter activity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (64 results)

All 2014 2013 2012 2011 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (46 results) (of which Invited: 2 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Basic Fibroblast Growth Factor Is Essential to Maintain Endothelial Progenitor Cell Phenotype in TR-BME2 Cells2014

    • Author(s)
      Sai Y, Nishimura T, Iizasa H
    • Journal Title

      Biol Pharm Bull

      Volume: 37 (4) Pages: 688-693

    • NAID

      130003390962

    • URL

      https://www.jstage.jst.go.jp/article/bpb/37/4/37_b13-00841/_article

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basic Fibroblast Growth Factor Is Essential to Maintain Endothelial Progenitor Cell Phenotype in TR-BME2 Cells.2014

    • Author(s)
      Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E.
    • Journal Title

      Biol Pharm Bull

      Volume: 37 Pages: 688-693

    • NAID

      130003390962

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhancement of in vitro cell motility and invasiveness of human malignant pleural mesothelioma cells through the HIF-1α-MUC1 pathway.2013

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakazawa S, Nakane R, Liang S, Hida Y, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Irimura T, Hamada J.
    • Journal Title

      Cancer Lett

      Volume: 339 Issue: 1 Pages: 82-91

    • DOI

      10.1016/j.canlet.2013.07.020

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and characterization of human breast cancer cells with SOX2 promoter activity.2013

    • Author(s)
      Liang S, Furuhashi M, Nakane R, Nakazawa S, Goudarzi H, Hamada J, Iizasa H.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Issue: 2 Pages: 205-211

    • DOI

      10.1016/j.bbrc.2013.06.038

    • NAID

      120005324564

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing.2013

    • Author(s)
      Ota H, Sakurai M, Gupta, R, Valente L, Wulff B-E, Ariyoshi K, Iizasa H, Davuluri RV, Nishikura K.
    • Journal Title

      Cell

      Volume: 153 (3) Issue: 3 Pages: 578-589

    • DOI

      10.1016/j.cell.2013.03.024

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells.2013

    • Author(s)
      Oda K, Nishimura T, Higuchi K, Ishido N, Ochi K, Iizasa H, Sai Y, Tomi M, Nakashima E.
    • Journal Title

      J Pharm Sci

      Volume: 102 Issue: 9 Pages: 3364-3372

    • DOI

      10.1002/jps.23549

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma2013

    • Author(s)
      Goudarzi H, Hida Y, Iizasa H
    • Journal Title

      Biomed Res

      Volume: 34 (1) Pages: 13-21

    • NAID

      130004470830

    • URL

      https://www.jstage.jst.go.jp/article/biomedres/34/1/34_13/_article

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus latent membrane protein 2A contributes to anoikis resistance through ERK activation2013

    • Author(s)
      Iwakiri D, Minamitani T, Samanta M
    • Journal Title

      J Virol

      Volume: 87 (14) Issue: 14 Pages: 8227-8234

    • DOI

      10.1128/jvi.01089-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypoxia affects in vitro growth of newly established cell lines from patients with malignant pleural mesothelioma.2013

    • Author(s)
      Goudarzi H, Hida Y, Takano H, Teramae H, Iizasa H, Hamada J.
    • Journal Title

      Biomed Res

      Volume: 34 Pages: 13-21

    • NAID

      130004470830

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr Virus (EBV)-associated gastric carcinoma2012

    • Author(s)
      Iizasa H, Nanbo A
    • Journal Title

      Viruses

      Volume: 4 (12) Pages: 3420-3439

    • URL

      http://www.mdpi.com/1999-4915/4/12/3420

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] EBV‐associated Gastric Carcinoma.2012

    • Author(s)
      Iizasa H, Nanbo A, Nishikawa J, Yoshiyama H.
    • Journal Title

      Viruses

      Volume: 4 (12) Issue: 12 Pages: 3420-3439

    • DOI

      10.3390/v4123420

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice2011

    • Author(s)
      Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y
    • Journal Title

      Blood

      Volume: 117 Issue: 21 Pages: 5663-5673

    • DOI

      10.1182/blood-2010-09-305979

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus virus-associated RNAs induce type I interferon expression a RIG-I-mediated pathway2011

    • Author(s)
      Minamitani, T., Iwakiri, D., Takada, K.
    • Journal Title

      J.Virol

      Volume: 85 Issue: 8 Pages: 4035-4040

    • DOI

      10.1128/jvi.02160-10

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 酸耐性形質を示すKingella Denitrificans亜株の異所性胃内分布と同菌によるHelicobacter pyloriの酸抵抗性の増強2014

    • Author(s)
      飯笹久(他3名)
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      タワーホール船掘(東京)
    • Year and Date
      2014-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素環境によるMUC1の転写活性化と悪性胸膜中皮腫細胞の運動・浸潤能の増強2013

    • Author(s)
      浜田淳一, ゴウダルジ•ホウマヌ, 飯笹久(他10名)
    • Organizer
      第11回がんとハイポキシア研究会
    • Place of Presentation
      東北大学片平さくらホール
    • Year and Date
      2013-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] MUC1は低酸素下におけるヒト悪性胸膜中皮腫細胞の運動・浸潤能の増強に中心的な役割を果たす2013

    • Author(s)
      ゴウダルジ•ホウマヌ, 飯笹久(他8名)
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] ピロリ菌感染が胃粘膜上皮細胞へのEBウイルス感染増殖を促進する2013

    • Author(s)
      林秦弘, 飯笹久(他4名)
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト乳がん細胞株から分離したSOX2プロモーター活性陽性細胞の解析2013

    • Author(s)
      飯笹久(他5名), 梁珊珊
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] RNA結合タンパク質p54^<nrb>は、SOX2プロモーター制御を介してSOX2の発現を抑制する2013

    • Author(s)
      梁珊珊, 飯笹久(他7名)
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] RNA結合タンパク質p54^<nrb>は、SOX2の転写•翻訳抑制を介して乳癌幹細胞様活性を制御する2013

    • Author(s)
      梁珊珊, 飯笹久(他7名)
    • Organizer
      第15回RNAミーティング
    • Place of Presentation
      松山全日空ホテル
    • Year and Date
      2013-07-25
    • Related Report
      2013 Final Research Report
  • [Presentation] EBV感染によるヒト上皮細胞の極性喪失について2013

    • Author(s)
      吉山裕規, 飯笹久(他6名)
    • Organizer
      第10回EBウイルス研究会
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Year and Date
      2013-07-12
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素下におけるMUC1の発現亢進はヒト悪性胸膜中皮腫細胞の細胞運動・浸潤能を増強する2013

    • Author(s)
      ゴウダルジ・ホウマヌ, 飯笹久(他10名)
    • Organizer
      第22回日本がん転移学会
    • Place of Presentation
      ホテルブエナビスタ(松本)
    • Year and Date
      2013-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] EBV感染によるヒト上皮細胞の極性喪失について.2013

    • Author(s)
      吉山裕規、飯笹久、呉里美、坂井香織、藤田奈々、林泰弘、南保明日香、高田賢蔵.
    • Organizer
      第10回EBウイルス研究会
    • Place of Presentation
      キャンパスプラザ京都(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA結合タンパク質p54nrbは、SOX2の転写翻訳抑制を介して乳癌幹細胞様活性を制御する.2013

    • Author(s)
      梁珊珊、藏滿保宏、廣瀬哲郎、古橋昌子、中根梨恵、中澤誠多朗、中村和行、浜田淳一、飯笹久.
    • Organizer
      第15回RNAミーティング
    • Place of Presentation
      県民文化会館ひめぎんホール (松山市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA結合タンパク質p54nrbは、SOX2プロモーター制御を介してSOX2の発現を抑制する.2013

    • Author(s)
      梁珊珊、藏滿保宏、廣瀬哲郎、古橋昌子、中根梨恵、中澤誠多朗、中村和行、浜田淳一、飯笹久.
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト乳がん細胞株から分離したSOX2プロモーター活性陽性細胞の解析.2013

    • Author(s)
      飯笹久、梁珊珊、古橋昌子、中根梨恵、中澤誠多朗、浜田淳一.
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ピロリ菌感染が胃粘膜上皮細胞へのEBウイルス感染増殖を促進する.2013

    • Author(s)
      林秦弘、西川潤、地主将久、飯笹久、高田賢蔵.吉山裕規.
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] RNA編集と遺伝子発現制御.2013

    • Author(s)
      飯笹久.
    • Organizer
      第36回分子生物学会年会 ワークショップ“RNAの包括的解析による細胞制御機構と疾患病態解明
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進がヒト悪性胸膜中皮腫細胞の運動・浸潤性を増強させる2012

    • Author(s)
      ゴウダルジ•ホウマヌ, 飯笹久(他7名)
    • Organizer
      第10回がんとハイポキシア研究会
    • Place of Presentation
      横浜開港記念会館(横浜)
    • Year and Date
      2012-12-07
    • Related Report
      2013 Final Research Report
  • [Presentation] MUC-1 plays an important role in enhancement motility and invasiveness of human malignant mesothelioma cells under hypoxia2012

    • Author(s)
      Goudarzi H, Iizasa H (他11名)
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito hall (Internatinal Research Center), Tokyo, Japan
    • Year and Date
      2012-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Latent expression of BNLF2a and BNLF2b in EBV-infected cells and their oncogenic roles2012

    • Author(s)
      Yoshiyama H, Nanbo A, Iizasa H(他3名)
    • Organizer
      4th Annual Conference of the Cancer Science Institute of Singapore (Fronties in Cancer Science 2012)
    • Place of Presentation
      Cancer Science Institute of Singapore, Singapore
    • Year and Date
      2012-11-05
    • Related Report
      2013 Final Research Report
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進が低酸素環境におけるヒト悪性胸膜中皮腫細胞の運動・浸潤能を増強させる2012

    • Author(s)
      ゴウダルジ•ホウマヌ, 飯笹久(他8名)
    • Organizer
      第92回北海道医学大会腫瘍系分科会
    • Place of Presentation
      北大医学部学友会館フラテ(札幌)
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進がヒト悪性胸膜中皮腫細胞の運動・浸潤性を増強させる2012

    • Author(s)
      ゴウダルジ•ホウマヌ, 飯笹久(他7名)
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] EBウイルス由来microRNA miR-BART6は上皮細胞に上皮間葉系移行を引き起こす2012

    • Author(s)
      飯笹久(他3名)
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌市教育文化会館(札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトLEFTY1遺伝子プロモーターを改変したKruppel-like factor 4レポーターシステムの開発2012

    • Author(s)
      林えりか, 飯笹久(他2名)
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト乳癌細胞株におけるSOX2プロモーター領域の解析2012

    • Author(s)
      梁珊珊, 飯笹久(他2名)
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Epstein-Barr virus-encoded BART6 microRNAs regulate viral latency and induce epithelial-mesenchymal transition2012

    • Author(s)
      Iizasa H, Yoshiyama H, Iwakiri D (他7名)
    • Organizer
      International Congress on Oncogenic Herpesviruses and Associated Diseases
    • Place of Presentation
      Shertaton Philadelphia City Center Hotel, Philadelphia, PA
    • Year and Date
      2012-08-02
    • Related Report
      2013 Final Research Report
  • [Presentation] ウイルス由来microRNAによる潜伏感染と上皮間葉移行の制御2012

    • Author(s)
      飯笹久, 吉山裕規, 西倉和子
    • Organizer
      第14回RNAミーティング
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール(仙台)
    • Year and Date
      2012-07-19
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト悪性胸膜中皮腫細胞の低酸素培養状態における細胞運動•浸潤能の増強(Selected as an oral presentation for workshop)2012

    • Author(s)
      ゴウダルジ•ホウマヌ, 飯笹久(他6名)
    • Organizer
      第21回日本がん転移学会
    • Place of Presentation
      オリエンタルホテル広島(広島)
    • Year and Date
      2012-07-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Epstein-Barr ウィルス由来microRNA miR-BART6による潜伏感染制御と上皮間葉移行.2012

    • Author(s)
      飯笹久.
    • Organizer
      北海道大学遺伝子病制御研究所平成24年度共同研究集会“感染、免疫、炎症、発癌”
    • Place of Presentation
      北海道大学医学部フラテ会館(札幌)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ヒト悪性胸膜中皮腫細胞の低酸素培養状態における細胞運動 浸潤能の増強2012

    • Author(s)
      ゴウダルジ ホウマヌ、飯笹久、古橋昌子、中澤誠多朗、中根梨恵、柳原五吉、久保貴紀、浜田淳一.
    • Organizer
      第21回日本がん転移学会
    • Place of Presentation
      オリエンタルホテル広島(広島)
    • Related Report
      2012 Research-status Report
  • [Presentation] ウイルス由来microRNAによる潜伏感染と上皮間葉移行の制御.2012

    • Author(s)
      飯笹久、吉山裕規、西倉和子
    • Organizer
      第14回日本RNA学会学術集会
    • Place of Presentation
      東北大学百周年記念会館川内萩ホール(仙台)
    • Related Report
      2012 Research-status Report
  • [Presentation] Epstein-Barr virus-encoded BART6 microRNAs regulate viral latency and induce epithelial-mesenchymal transition.2012

    • Author(s)
      Iizasa H, Yoshiyama H, Wulff BE, Maragkakis M, Hatzigeorgious A, Iwakiri D, Wiedmer A, Showe L, Lieberman P, Nishikura K.
    • Organizer
      International Congress on Oncogenic Herpesviruses and Associated Diseases
    • Place of Presentation
      Shertaton Philadelphia City Center Hotel(Philadelphia)
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進が低酸素環境におけるヒト悪性胸膜中皮腫細胞の運動・浸潤能を増強させる.2012

    • Author(s)
      ゴウダルジ ホウマヌ、飯笹久、古橋昌子、中根梨恵、中澤誠多朗、樋田秦浩、柳原五吉、久保貴紀、入村達郎、浜田淳一.
    • Organizer
      第92回北海道医学大会腫瘍系分科会
    • Place of Presentation
      北大医学部学友会館フラテ(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト乳癌細胞株におけるSOX2プロモーター領域の解析.2012

    • Author(s)
      梁珊珊、飯笹久、古橋昌子、浜田淳一
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進がヒト悪性胸膜中皮腫細胞の運動・浸潤性を増強させる.2012

    • Author(s)
      ゴウダルジ ホウマヌ、飯笹久、古橋昌子、中根梨恵、中澤誠多朗、樋田泰浩、柳原五吉、久保貴紀、浜田淳一
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] EBウィルス由来microRNA miR-BART6は上皮細胞に上皮間葉系移行を引き起こす2012

    • Author(s)
      飯笹久、吉山裕規、川野光興、西倉和子.
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒトLEFTY1遺伝子プロモーターを改変したKruppel-like factor 4 レポーターシステムの開発.2012

    • Author(s)
      林えりか、飯笹久、梁珊珊、浜田淳一.
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      ロイトン札幌(札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] Latent expression of BNLF2a and BNLF2b in EBV-infected cells and their oncogenic roles.2012

    • Author(s)
      Yoshiyama H, Nanbo A, Jinushi M, Iizasa H, Shimizu N, Takada K.
    • Organizer
      Fronties in Cancer Science 2012; 4th Annual Conference of the Cancer Science Institute of Singapore
    • Place of Presentation
      Cancer Science Institute of Singapore(Singapore)
    • Related Report
      2012 Research-status Report
  • [Presentation] MUC-1 plays an important role in enhancement motility and invasiveness of human malignant mesothelioma cells under hypoxia.2012

    • Author(s)
      Goudarzi H, Iizasa H, Furuhashi M, Nakane R, Nakazawa S, Liang S, Yanagihara K, Kubo T, Nakagawa K, Kobayashi M, Hida Y, Irimura T, Hamada J.
    • Organizer
      International Symposium on Glyco-minded Biology of Diseases as a Basis of Pharmaceutical Sciences
    • Place of Presentation
      Ito hall (Internatinal Research Center)(Tokyo)
    • Related Report
      2012 Research-status Report
  • [Presentation] HIF1alpha依存的なMUC1の発現亢進がヒト悪性胸膜中皮腫細胞の運動・浸潤性を増強させる.2012

    • Author(s)
      ゴウダルジ ホウマヌ、飯笹久、古橋昌子、中根梨恵、中澤誠多朗、樋田泰浩、柳原五吉、久保貴紀、浜田淳一.
    • Organizer
      第10回がんとハイポキシア研究会.
    • Place of Presentation
      横浜開港記念会館(横浜)
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト悪性胸膜中皮腫細胞のin vitro増殖能に及ぼす低酸素の影響2011

    • Author(s)
      浜田淳一, Goudarzi Houman, 飯笹久(他6名)
    • Organizer
      第9回がんとハイポキシア研究会
    • Place of Presentation
      東京(学習院大)
    • Year and Date
      2011-11-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 低酸素条件下の培養はヒト悪性胸膜中皮腫細胞の悪性化を促進する2011

    • Author(s)
      ゴウダルジ・ホウマヌ, 飯笹久(他3名)
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] ウイルス由来microRNAによるウイルス潜伏感染調節機構の解析2011

    • Author(s)
      飯笹久(他8名), Bjorn-Erik Wulff, 岩切大
    • Organizer
      第5回北大若手研究者交流会
    • Place of Presentation
      札幌
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳癌細胞株におけるSOX2プロモーター領域の解析2011

    • Author(s)
      梁珊珊, 飯笹久(他3名)
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト悪性胸膜中皮腫細胞の低酸素培養条件下における増殖・運動・浸潤能の変化2011

    • Author(s)
      ゴウダルジ・ホウマヌ, 飯笹久(他2名)
    • Organizer
      第20回日本がん転移学会学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2011-07-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 乳癌細胞株におけるSOX2プロモーター領域の解析2011

    • Author(s)
      梁珊珊、飯笹久、古橋昌子、浜田淳一
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知)
    • Related Report
      2011 Research-status Report
  • [Presentation] ウィルス由来microRNAによるウィルス潜伏感染調節機構の解析2011

    • Author(s)
      飯笹久, Bjorn-Erik Wulff, Manolis Maragkakis, Molly Megraw, Artemis Hatzigeorgious, 岩切大, 高田賢蔵, Andreas Wiedmer, Louis Showe, Paul Lieberman, 西倉和子
    • Organizer
      第5回北大若手研究者交流会
    • Place of Presentation
      北海道大学医学部フラテ会館(札幌)
    • Related Report
      2011 Research-status Report
  • [Presentation] 乳癌細胞株におけるSOX2発現調節領域の解析2011

    • Author(s)
      梁珊珊、飯笹久、古橋昌子、中澤誠多朗、中根梨恵、大場雄介、浜田淳一
    • Organizer
      第5回北大若手研究者交流会
    • Place of Presentation
      北海道大学医学部フラテ会館(札幌)
    • Related Report
      2011 Research-status Report
  • [Book] MicroRNAs and oncogenic human viruses2014

    • Author(s)
      Thirion M, Kanda T, Murakami Y, Ochiya T, Iizasa H
    • Publisher
      MicroRNAs : Key Regulators of Oncogenesis. (Ed. Sadegh Babashah)
    • Related Report
      2013 Final Research Report
  • [Book] “MicroRNAs and oncogenic human viruses.” MicroRNAs: Key Regulators of Oncogenesis.2014

    • Author(s)
      Thirion M, Kanda T, Murakami Y, Ochiya T and Iizasa H.
    • Total Pages
      433
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] A-to-I RNA編集とウイルス感染—宿主防御因子としてのADAR1の役割—.医学のあゆみ第5土曜特集RNA医学•医療—あらたな診断•治療を拓く2011

    • Author(s)
      飯笹久
    • Publisher
      中村義一企画.(医歯薬出版)
    • Related Report
      2013 Final Research Report
  • [Book] A-to-I RNA 編集とウィルス感染―宿主防御因子としてのADAR1の役割2011

    • Author(s)
      飯笹久
    • Publisher
      医歯薬出版
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.igm.hokudai.ac.jp/crg/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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