The analysis of the new inhibitory factor for cytomegalovirus in ES/iPS cells
| Project/Area Number |
23590445
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOSUGI Isao 浜松医科大学, 医学部, 准教授 (10252173)
ARAI Yoshihumi 浜松医科大学, 医学部, 助教 (30381784)
IWASHITA Toshihide 浜松医科大学, 医学部, 教授 (00283432)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ES / iPS / サイトメガロウイルス / β1 インテグリン / 大脳 / レセプター / ES細胞 |
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| Research Abstract |
Pluripotent stem cell (iPS/ES cells) showed resistance to CMV. We established iPS cells from human fibroblast using Yamanka factors. iPS showed remarkable resistance to CMV infection. This is the compatible with previous report (Plos one: 10.1371/journal.pone.0017492). We tried to investigate the new factor for this inhibitory phenomenon.The new factor has not been found yet. Instead, we tried to find known receptor (CD29) distribution for CMV in brain. Endothelial cells, pericytes, meninges, choloid plexus and NSPC all express higher level of CD29 than other area of the brain. Co-expression of higher level of CD29 expressing cells and MCMV infected cells were highly correlated. In the brain. We concluded that cytomegalovirus infection primarily initiates infection from high-level CD29 expressing cells in acute infection phase.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection - in vivo identification of cytomegalovirus persistent infected cells2013
Author(s)
Matsumura K, Nakase H, Kosugi I, Honzawa Y, Yoshino T, Matsuura M, Kawasaki H, Arai Y, Iwashita T, Nagasawa T, Chiba T
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Journal Title
Inflammatory Bowel Disease
Volume: 19(9)
Pages: 1951-1956
Related Report
Peer Reviewed
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[Journal Article] An autopsy case of the marburg variant of multiple sclerosis (acute multiple sclerosis)2013
Author(s)
Suzuki M, Kawasaki H, Masaki K, Suzuki S, Terada T, Tsuchida T, Tokuyama T, Kono S, Komori T, Baba S, Kira J, Miyajima H
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Journal Title
Intern Med.
Volume: 52(16)
Pages: 1825-1832
NAID
Related Report
Peer Reviewed
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[Journal Article] Establishment of a novel mouse model of ulcerative colitis with concomitant cytomegalovirus infection - in vivo identification of cytomegalovirus persistent infected cells,2013
Author(s)
Matsumura K, Nakase H, Kosugi I, Honzawa Y, Yoshino T, Matsuura M, Kawasaki H, Arai Y, Iwashita T, Nagasawa T, Chiba T.
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Journal Title
Inflammatory Bowel Disease
Volume: 19
Pages: 1951-1956
Related Report
Peer Reviewed
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[Journal Article] Effects of intrapulmonary viral tropism and cytokine expression on the histological patterns of cytomegalovirus pneumonia2012
Author(s)
Arai Y, Tsuchida T, Kosugi I, Kawasaki H, Meguro S, Kinoshita M, Baba S, Maeda M, Shinmura Y, Tsutsui Y, Iwashita T
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Journal Title
Pathol Int
Volume: 62
Pages: 628-639
Related Report
Peer Reviewed
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