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Elucidation of the regulatory mechanism for claudin-5 expression in vascular endothelial cells

Research Project

Project/Area Number 23590447
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionYamaguchi University

Principal Investigator

CUI Dan  山口大学, 医学(系)研究科(研究院), 講師 (40346549)

Co-Investigator(Kenkyū-buntansha) IKEDA Eiji  山口大学, 大学院医学系研究科, 教授 (30232177)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords血液脳関門 / 血液網膜関門 / タイト結合 / 低酸素 / クローディン5 / グローディン5 / タイト結結合
Research Abstract

Tissue hypoxia is known to accelerate the progression of intractable neural diseases through the breakdown of neural vascular barrier including the blood-brain barrier and the inner blood-retinal barrier. However, the mechanisms underlying the hypoxia-induced breakdown of vascular barrier remain unclarified. Here, using the in vitro and in vivo models of neural vascular barrier, we have specified two molecules, M1 and M2, as the indispensable molecules for hypoxia-induced breakdown of neural vascular barrier, and therefore the candidate molecules for new therapeutic targets of intractable neural diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (7 results)

All 2013 2012

All Presentation (5 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Presentation] 疾患生物学ワークショップ1AW11低酸素バイオロジーの最前線;代謝調節による細胞機能制御―神経系血管バリアー機能の酸素濃度依存性調節機構2013

    • Author(s)
      池田栄二
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸、神戸ポートアイランド
    • Related Report
      2013 Final Research Report
  • [Presentation] 崔丹血液脳関門の酸素濃度依存性調節機構2013

    • Author(s)
      池田栄二
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      北海道、ロイトン札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] 血液脳関門の酸素濃度依存性調節機構2013

    • Author(s)
      池田栄二、崔丹
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌,(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Deferroxamine刺激下の脳血管内皮細胞におけるclaudin-5発現解析2012

    • Author(s)
      岩本沙也加、崔丹、高橋睦夫、河野裕夫、池田栄二
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      東京、京王プラザホテル
    • Related Report
      2013 Final Research Report
  • [Presentation] Deferoxamine刺激下の脳血管内皮細胞におけるclaudin-5発現解析2012

    • Author(s)
      岩本沙也加、崔丹、高橋睦夫、河野裕夫、池田栄二
    • Organizer
      第101回日本病理学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2012 Research-status Report
  • [Patent(Industrial Property Rights)] 神経疾患治療剤2013

    • Inventor(s)
      池田栄二、崔丹
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-04-25
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 神経疾患治療剤2013

    • Inventor(s)
      池田栄二、崔 丹
    • Industrial Property Rights Holder
      山口大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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