Meis1 regulates epidermal stem cells and is required for skin tumorigenesis
| Project/Area Number |
23590454
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
WAKABAYASHI Yuichi 千葉県がんセンター(研究所), 実験動物研究室, 室長 (40303119)
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| Co-Investigator(Kenkyū-buntansha) |
奥村 和弘 千葉県がんセンター研究所 (80584680)
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| Co-Investigator(Renkei-kenkyūsha) |
後飯塚 僚 東京理科大学 (50301552)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 発がん / 幹細胞 / 表皮 / 化学発がん / Meis1 / アメリカ合衆国 / 表皮幹細胞 |
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| Research Abstract |
We uncover two roles for Meis1 in the epidermis: as a critical regulator of epidermal homeostasis in normal tissues and as a proto-oncogenic factor in neoplastic tissues. In normal epidermis, we show that Meis1 is predominantly expressed in the bulge region of the hair follicles where multipotent adult stem cells reside, and that the number of these stem cells is reduced when Meis1 is deleted in the epidermal tissue of mice. Mice with epidermal deletion of Meis1 developed significantly fewer DMBA/TPA-induced benign and malignant tumors compared with wild-type mice, suggesting that Meis1 plays a role in both tumor development and malignant progression. This is consistent with the observation that Meis1 expression increases as tumors progress from benign papillomas to malignant carcinomas.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Multiple Self-Healing Squamous Epithelioma (MSSE): a digenic or multilocus trait caused by TGFBR1 mutations and rare variants in an adjacent region of chromosome 9q22.32013
Author(s)
Kang, H.C., Quigley, D., Kim, I.J., Wakabayashi, Y., Dunlop, M., Ferguson-Smith, M.A., Goudie, D.R., Balmain, A.
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Journal Title
J. Invest. Dermatol.
Volume: 133
Issue: 7
Pages: 1907-1910
DOI
Related Report
Peer Reviewed
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[Journal Article] PTCH overexpression drives skin carcinogenesis and developmental defects in K14 PTCHFVB mice2013
Author(s)
Kang, H.C., Wakabayashi, Y., Jen, K.Y., Mao, J.H., Del-Rosario, R., Balmain, A.
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Journal Title
J. Invest. Dermatol.
Volume: 133
Issue: 5
Pages: 1311-1320
DOI
Related Report
Peer Reviewed
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