| Project/Area Number |
23590455
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Yamaguchi University (2012-2013)
University of Fukui (2011) |
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Principal Investigator |
ITOH HIROSHI 山口大学, 医学(系)研究科(研究院), 教授 (80253847)
|
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| Co-Investigator(Renkei-kenkyūsha) |
NAGANUMA Seiji 高知大学, 医学部, 助教 (50452123)
KATAOKA Hiroaki 宮崎大学, 医学部, 教授 (10214321)
KITAMURA Naomi 東京工業大学, 生命理工学研究科, 教授 (80107424)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | マイクロRNA / 細胞増殖因子 / 転写翻訳調節 / HGF / 癌細胞 / 頭頚部癌 / 前立腺癌 / アンドロゲン / 頭頸部癌 |
|---|
| Research Abstract |
MicroRNAs miR-200c and miR-27b, both of which were down-regulated by HGF stimulation in cultured human head and neck squamous carcinoma cells (HNSCC), might play an important role in EMT mediated by ZEB1 and ECM degradation and HGF auto-activation mediated by ST-14/matriptase, respectively. Altered expression of these microRNAs directly regulated by HGF might contribute enhanced progressive and invasive characteristics of HNSCC by regulating the translation of HGF-induced functional molecules. We also confirmed that the expression of miR-182 depends on the cancer grade even in same Gleason pattern 4 of prostate cancer. Expression of miR-182 associated with Gleason grading system in biopsy sample may contribute to more accurate preoperative cancer risk evaluation.
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