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Regulation of microRNA by stimulation of growth factors in various cancer cells

Research Project

Project/Area Number 23590455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionYamaguchi University (2012-2013)
University of Fukui (2011)

Principal Investigator

ITOH HIROSHI  山口大学, 医学(系)研究科(研究院), 教授 (80253847)

Co-Investigator(Renkei-kenkyūsha) NAGANUMA Seiji  高知大学, 医学部, 助教 (50452123)
KATAOKA Hiroaki  宮崎大学, 医学部, 教授 (10214321)
KITAMURA Naomi  東京工業大学, 生命理工学研究科, 教授 (80107424)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsマイクロRNA / 細胞増殖因子 / 転写翻訳調節 / HGF / 癌細胞 / 頭頚部癌 / 前立腺癌 / アンドロゲン / 頭頸部癌
Research Abstract

MicroRNAs miR-200c and miR-27b, both of which were down-regulated by HGF stimulation in cultured human head and neck squamous carcinoma cells (HNSCC), might play an important role in EMT mediated by ZEB1 and ECM degradation and HGF auto-activation mediated by ST-14/matriptase, respectively. Altered expression of these microRNAs directly regulated by HGF might contribute enhanced progressive and invasive characteristics of HNSCC by regulating the translation of HGF-induced functional molecules. We also confirmed that the expression of miR-182 depends on the cancer grade even in same Gleason pattern 4 of prostate cancer. Expression of miR-182 associated with Gleason grading system in biopsy sample may contribute to more accurate preoperative cancer risk evaluation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (20 results) Remarks (1 results)

  • [Journal Article] Expression of MicroRNAs associated with Gleason grading system in prostate cancer: miR-182-5p is a useful marker for high grade prostate cancer.2013

    • Author(s)
      Tsuchiyama, K., Ito, H., Taga, M., Naganuma, S., Oshinoya, Y., Nagano, K.-i., Yokoyama, O. and Itoh, H.
    • Journal Title

      Prostate

      Volume: 73 Issue: 8 Pages: 827-34

    • DOI

      10.1002/pros.22626

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma2012

    • Author(s)
      Naganuma S, Whelan KA, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, Subramanian H, Rhoades B, Ohashi S, Itoh H, Herlyan M, Diehl JA, Gimotty PA, Klein-Szanto AJ, Nakagawa H
    • Journal Title

      Am J Cancer Res

      Volume: 2 Pages: 459-475

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch receptor inhibition reveals the importance of cyclin D1 and Wnt signaling in invasive esophageal squamous cell carcinoma.2012

    • Author(s)
      Naganuma S, Whelan KA, Natsuizaka M, Kagawa S, Kinugasa H, Chang S, Subramanian H, Rhoades B, Ohashi S, Itoh H, Herlyn M, Diehl JA,Gimotty PA, Klein-Szanto AJ, Nakagawa H.
    • Journal Title

      Am J Cancer Res

      Volume: 2 Pages: 459-475

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regional quantification of muscarinic acetylcholine receptors and β-adrenoceptors in human airways2012

    • Author(s)
      Ikeda T, Anisuzzaman AS, Yoshiki H, Sasaki M, Koshiji T, Uwada J, Nishimune A, Itoh H, Muramatsu I
    • Journal Title

      British Journal of Pharmacology

      Volume: (In press) Issue: 6 Pages: 1804-1814

    • DOI

      10.1111/j.1476-5381.2012.01881.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma2011

    • Author(s)
      Dai Susuki, Sotai Kimura, Seiji Naganuma, Katsuki Tsuchiyama, Toshiaki Tanaka, Naomi Kitamura, Shigeharu Fujieda, Hiroshi Itoh
    • Journal Title

      Cancer science

      Volume: 102(12) Issue: 12 Pages: 2164-2171

    • DOI

      10.1111/j.1349-7006.2011.02096.x

    • NAID

      10030245835

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors2011

    • Author(s)
      Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kaiman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H
    • Journal Title

      Cancer Res

      Volume: 71 Issue: 21 Pages: 6836-6847

    • DOI

      10.1158/0008-5472.can-11-0846

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A NOTCH3-mediated squamous cell differentiation program limits expansion of EMT-competent cells that express the ZEB transcription factors.2011

    • Author(s)
      Ohashi S, Natsuizaka M, Naganuma S, Kagawa S, Kimura S, Itoh H, Kaiman RA, Nakagawa M, Darling DS, Basu D, Gimotty PA, Klein-Szanto AJ, Diehl JA, Herlyn M, Nakagawa H
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 6836-6847

    • Related Report
      2011 Research-status Report
  • [Presentation] 腹膜偽粘液腫の病理学的検討2014

    • Author(s)
      高原千咲, 濱崎太郎, 小賀厚徳, 伊藤秀明, 伊藤浩史
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島(広島国際会議場)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 子宮頚部腺癌におけるp16発現とh-HPV感染の検討2014

    • Author(s)
      名尾知絵, 河内茂人, 池本健三, 伊藤秀明, 奥田信一郎, 伊藤浩史
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島(広島国際会議場)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Comparison of proliferative capability of neoplastic and non-neoplastic cells by image cytometry2013

    • Author(s)
      Ito H, Oga A, Ikemoto K, Kondo T, Chochi Y, Kawauchi S, Sasaki K, Itoh H
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2013-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of proliferative capability of neoplastic and non-neoplastic cells by image cytometry2013

    • Author(s)
      Hideaki Ito, Atsunori Oga,Kenzo Ikemoto, Tomoko Kondo, Yasuyo Chochi, Shigeto Kawauchi, Kohsuke Sasaki, Hiroshi Itoh
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The inhibitory effect of autophagy induced by mTOR inhibitor on cell proliferation in renal cell carcinoma2012

    • Author(s)
      Taga M, Ito H, Taga M, Inamura S, Tsuchiyama K, Naganuma S, Yakoyama O, Itoh H
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] A genetic crosstalk with Notch signaling in an organotypic 3D culture model of squamous cell carcinoma2012

    • Author(s)
      Naganuma S, Natsuizaka M, Ohashi S, Nakagawa H, Itoh H
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2012-12-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of microRNAs associated with Gleason grading system in prostate cancer2012

    • Author(s)
      Tsuchiyama K, Ito H, Taga M, Naganuma S, Yakoyama O, Itoh H
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌(ロイトン札幌)
    • Year and Date
      2012-09-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Relationship between microRNA expression and Gleason grading system in prostate cancer2012

    • Author(s)
      Tsuchiyama K, Ito H, Taga M, Oshinoya K, Nagano K, Yokoyama O, Itoh H
    • Organizer
      103rd Annual meeting, American Association for Cancer Research (AACR)
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2012-04-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of microRNAs associated with Gleason grading system in prostate cancer.2012

    • Author(s)
      Tsuchiyama K, Ito H, Taga M, Naganuma S, Yokoyama O, Itoh H.
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌(ロイトン札幌)
    • Related Report
      2012 Research-status Report
  • [Presentation] The inhibitory effect of autophagy induced by mTOR inhibitor on cell proliferation in renal cell carcinoma2012

    • Author(s)
      Minekatsu Taga, Hideaki Ito, So Inamura, Katsuki Tsuchiyama, Seiji Naganuma, Osamu Yokoyama, Hiroshi Itoh
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] A genetic crosstalk with Notch signaling in an organotypic 3D culture model of squamous cell carcinoma2012

    • Author(s)
      Seiji Naganuma, Mitsuteru Natsuizaka, Shinya Ohashi, Hiroshi Nakagawa, Hiroshi Itoh, et al
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Related Report
      2012 Research-status Report
  • [Presentation] 前立腺癌におけるGleason grading systemと相関するmicroRNAの発現解析2011

    • Author(s)
      土山克樹,伊藤秀明,多賀峰克,押野谷幸之助,長野賢一,伊藤浩史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト頭頚部扁平上皮癌における肝細胞増殖因子によるマイクロRNA発現調節2011

    • Author(s)
      鈴木弟,土山克樹,木村相泰,長沼誠二,藤枝重治,喜多村直実,伊藤浩史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2011-12-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 前立腺癌のGleason grading systemと関連するmicroRNAの発現解析2011

    • Author(s)
      土山克樹,伊藤秀明,多賀峰克,伊藤浩史
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2011-10-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma2011

    • Author(s)
      Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H
    • Organizer
      102nd Annual meeting, American Association for Cancer Research (AACR)
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-04-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma.2011

    • Author(s)
      Susuki D, Kimura S, Naganuma S, Tsuchiyama K, Tanaka T, Kitamura N, Fujieda S, Itoh H
    • Organizer
      102nd Annual Meeting of American Association for Cancer Research
    • Place of Presentation
      Orlando FL, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] 前立腺癌のGleason grading systemと関連するmicroRNAの発現解析2011

    • Author(s)
      土山克樹, 伊藤秀明, 多賀峰克, 伊藤浩史
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 前立腺癌におけるGleason grading systemと相関するmicroRNAの発現解析2011

    • Author(s)
      土山克樹, 伊藤秀明, 多賀峰克, 押野谷幸之助, 長野賢一, 伊藤浩史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] ヒト頭頸部扁平上皮癌における肝細胞増殖因子によるマイクロRNA発現調節2011

    • Author(s)
      鈴木弟, 土山克樹, 木村相泰, 長沼誠二, 藤枝重治, 喜多村直実,  伊藤浩史
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] Relationship between microRNA expression and Gleason grading system in prostate cancer

    • Author(s)
      Katsuki Tsuchiyama, Hideaki Ito, Minekatsu Taga, Konosuke Oshinoya, Kenichi Nagano, Osamu Yokoyama, Hiroshi Itoh
    • Organizer
      102nd Annual Meeting of American Association of Cancer Research (AACR)
    • Place of Presentation
      Chicago, IL, USA
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://ds.cc.yamaguchi-u.ac.jp/~2byouri/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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