Elucidation of the crucial role of Adrenomedullin-Ramp2,Ramp3 system in mouse models of inflammation

• Project/Area Number: 23590456
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Shinshu University
• Principal Investigator: SAKURAI Takayuki 信州大学, 医学系研究科, 准教授 (80317825)
• Co-Investigator(Kenkyū-buntansha): SHINDO Takayuki 信州大学, 医学系研究科, 教授 (90345215)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: アドレノメデュリン / 受容体修飾因子 / RAMP / 血管作動性ペプチド / 心血管系 / 疾患モデル動物 / 発生工学 / 炎症 / 恒常性維持 / ＲＡＭＰ

Research Abstract

Receptor-activity-modifying protein (Ramp) 2 or 3 is a part of the Adrenomedullin (AM) receptor. The Ramps became suggested to be important for unique AM function. In this study, the role of Adrenomedullin-Ramp2, Ramp3 system were investigated in inflammatory conditions of the peritoneum and the colon, including pathological conditions of several organs (blood vessel, heart and kidney) by using Ramp2 conditional KO and Ramp3KO mice. It has revealed that Ramp2 is involved in supporting organ function, and Ramp3 plays a crucial role in inflammatory response. These results obtained suggest that the Ramps function independently of each other, however they make a coordinated response for maintaining organ homeostasis.

Research Products

• [Journal Article] Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection (2014)
  • Author(s): Uetake R, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Yoshizawa T, Koyama T, Yang L, Toriyama Y, Yamauchi A, Igarashi K, Tanaka M, Kuwabara T, Mori K, Yanagita M,Mukoyama M, Shindo T
  • Journal Title: PLoSOne Volume: 9(2)
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system suppresses ER stress-induced tubule cell death and is involved in kidney protection (2014)
  • Author(s): Uetake et al.,
  • Journal Title: PlosONE Volume: 9(2)
  • Peer Reviewed
• [Journal Article] 血管内皮細胞のアドレノメデュリンーRAMP2システムは、小胞体ストレス誘導性細胞死を抑制し、腎保存的に働く (2013)
  • Author(s): 植竹龍一、桜井敬之、神吉昭子、新藤優佳、河手久香、吉沢隆浩、小山晃英、家里康弘、Yang L、鳥山祐一、山内啓弘、五十嵐恭子、田中愛、新藤隆行
  • Journal Title: 血管 Volume: Vol36 Pages: 89-93
• [Journal Article] Regulation of adrenomedullin and its family peptide by RAMP system-lessons from genetically engineered mice (2013)
  • Author(s): Shindo T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Shimoyama N, Iinuma N, Arai T, Miyagawa S
  • Journal Title: Curr Protein Pept Sci Volume: 14 (5) Pages: 347-357
  • NAID: 120007100587
  • Peer Reviewed
• [Journal Article] Vascular endothelial adrenomedullin-RAMP2 system is essential for vascular integrity and organ homeostasis (2013)
  • Author(s): Koyama T, Ochoa-Callejero L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Arai T, Yoshizawa T, Iesato Y, Lei Y, Uetake R, Okimura A, Yamauchi A, Tanaka M, Igarashi K, Toriyama Y, Kawate H, Adams RH, Kawakami H, Mochizuki N, Martínez A, Shindo T
  • Journal Title: Circulation Volume: 19;127 (7) Pages: 842-853
  • NAID: 120007108253
  • Peer Reviewed
• [Journal Article] Novel regulation of cardiac metabolism and homeostasis by the adrenomedullin receptor activity modifying protein 2 system (2013)
  • Author(s): Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T
  • Journal Title: Hypertension Volume: 61(2) Pages: 341-351
  • Peer Reviewed
• [Journal Article] Endogenous CGRP protects against neointimal hyperplasia following wire-induced vascular injury (2013)
  • Author(s): Yang L, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Iesato Y, Uetake R, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Shindo T
  • Journal Title: J Mol Cell Cardiol Volume: 59 Pages: 55-66
  • NAID: 120007108263
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis (2013)
  • Author(s): Iesato Y, Toriyama Y, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Yoshizawa T, Koyama T, Uetake R, Yang L, Yamauchi A, Tanaka M, Igarashi K, Murata T, Shindo T
  • Journal Title: Am J Pathol Volume: 182 (6) Pages: 2380-2390
  • Peer Reviewed
• [Journal Article] Regulation of adrenomedullin and its family peptide by RAMP system--lessons from genetically engineered mice. (2013)
  • Author(s): Shindo et al.,
  • Journal Title: Curr Protein Pept Sci Volume: 14(5) Issue: 5 Pages: 347-357
  • DOI: 10.2174/13892037113149990052
  • NAID: 120007100587
  • Peer Reviewed
• [Journal Article] Vascular Endothelial Adrenomedullin-RAMP2 System 18 Essential for Vascular Integrity and Organ Homeostasis (2013)
  • Author(s): Teruhide Koyama. Laura Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Arai, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Tbriyama, Ralf H. Adams, Hayato Kawakami, Naoki Mochizuki, Alfredo Martinez, Takayuki Shindo
  • Journal Title: Circulation Volume: 127 Issue: 7 Pages: 842-853
  • DOI: 10.1161/circulationaha.112.000756
  • Peer Reviewed
• [Journal Article] Novel regulation pf cardiac metabolism and homeostasis by the adrenomedullin- receptor activity-modifying protein 2 system (2013)
  • Author(s): Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Yasuhiro Iesato, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Tsutomu Nakada, Toshihide Kashihara, Mitsuhiko Yamada, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Hiroshi Akazawa, Takayuki Shindo
  • Journal Title: Hypertension Volume: 61 Issue: 2 Pages: 341-351
  • DOI: 10.1161/hypertensionaha.111.00647
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system is crucially involved in retinal angiogenesis (2013)
  • Author(s): Iesato Y, Tanaka M, et al.
  • Journal Title: Am J Pathol. Volume: 182 Issue: 6 Pages: 2380-90
  • DOI: 10.1016/j.ajpath.2013.02.015
  • Peer Reviewed
• [Journal Article] アドレノメデュリンーRAMP2系による心臓エネルギー代謝制御と恒常性維持機構 (2012)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、新藤優佳、河手久香、荒居琢磨、小山晃英、家里康弘、Yang L、植竹龍一、山内啓弘、田中愛、川上速人、中西広樹、田口良、新藤隆行
  • Journal Title: 血管 Volume: Vol34 Pages: 153-157
• [Journal Article] Endogenous CGEP protects against neointimal hyperplasia following wire-induced vascular injury (2012)
  • Author(s): Lei Yang, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Hisaka Kawate, Takahiro Yoshizawa, Tteruhide Kovama. Yasuhiro Iesato, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Yuichi Toriyama, Kyoko Igarashi, Takayuki Shindo
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 59 Pages: 55-56
  • DOI: 10.1016/j.yjmcc.2013.02.002
  • Peer Reviewed
• [Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling (2011)
  • Author(s): Arai T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Iinuma N, Iesato Y, Koyama T, Yoshizawa T, Uetake R, Yamauchi A, Yang L, Kawate H, Ogawa S, Kobayashi A, Miyagawa S, Shindo T
  • Journal Title: Peptides Volume: 32 (9) Pages: 1855-1865
  • NAID: 120007100611
  • Peer Reviewed
• [Journal Article] 血管内皮細胞のアドレノメデュリンーRAMP2システムによる血管恒常性維持機構 (2011)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、新藤優佳、河手久香、荒居琢磨、家里康弘、吉沢隆浩、Yang L、植竹龍一、五十嵐恭子、鳥山祐一、沖村綾乃、山内啓弘、田中愛、新藤隆行
  • Journal Title: 血管 Volume: Vol34 Pages: 33-36
  • NAID: 10030334834
• [Journal Article] Induction of LYVE-1/stabilin-2-positive liver sinusoidal endothelial-like cells from embryoid bodies by modulation of adrenomedullin-RAMP2 signaling. (2011)
  • Author(s): Arai T, et al.
  • Journal Title: Peptides Volume: 32 Pages: 1855-1865
  • Peer Reviewed
• [Journal Article] Adrenomedullin-RAMP2 system in cardiovascular development and homeostasis. (2011)
  • Author(s): Shindo T et al.
  • Journal Title: Current Hypertension Reviews Volume: 7 Pages: 217-227
  • Peer Reviewed
• [Presentation] アドレノメデュリン-RAMP2システムの代謝制御における役割 (2013)
  • Author(s): 神吉昭子、桜井敬之、新藤優佳、小山晃英、吉沢隆浩、楊磊、家里康弘、植竹龍一、山内啓弘、五十嵐恭子、鳥山佑一、田中愛、河手久香、新藤隆行
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良
• [Presentation] アドレノメデュリン-RAMP2システムは、小胞体ストレス誘導性細胞死を抑制し、腎保護的に働く (2013)
  • Author(s): 植竹龍一、桜井敬之、神吉昭子、河手久香、新藤優佳、吉沢隆浩、小山晃英、家里康弘、楊磊鳥山佑一、山内啓弘、五十嵐恭子、田中愛、新藤隆行
  • Organizer: 第42回日本心脈管作動物質学会
  • Place of Presentation: 奈良
• [Presentation] Metabolic Regulations by Adrenomedullin-RAMP2 System (2013)
  • Author(s): Akiko Kamiyoshi, Takayuki Sakurai, Yuka Shindo1, Hisaka Kawate, Teruhide Koyama, Takahiro Yoshizawa, Yang Lei, Yasuhiro Iesato, Ryuichi Uetake, Akihiro Yamauchi, Kyoko Igarashi, Yuichi Toriyama, Megumu Tanaka, Takayuki Shindo
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] Pathophysiological significance of Adrenomedullin-RAMP2 system in chronic kidney disease (2013)
  • Author(s): Ryuichi Uetake, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate, Yasuhiro Iesato, Takahiro Yoshizawa, Teruhide Koyama, Lei Yang, Yuichi Toriyama, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Takayuki Shindo
  • Organizer: 第77回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] 慢性腎臓病におけるアドレノメデュリン-RAMP2系の病態生理学的意義の解明 (2013)
  • Author(s): 植竹龍一、桜井敬之、神吉昭子、新藤優佳、河手久香、楊磊、吉沢隆浩、小山晃英、新藤隆行
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 仙台
• [Presentation] アドレノメデュリン-RAMP2システムの代謝制御における意義 (2013)
  • Author(s): 神吉昭子、桜井敬之、新藤優佳、小山晃英、吉沢隆浩、楊磊、家里康弘、植竹龍一、山内啓弘、五十嵐恭子、鳥山祐一、田中愛、河手久香、新藤隆行
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 仙台
• [Presentation] Adrenomedullin-RAMP2 system suppresses ER stress-induced cell death and works for kidney protection (2013)
  • Author(s): Ryuichi Uetake, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate, Yasuhiro Iesato, Takahiro Yoshizawa, Teruhide Koyama, Motoko Yanagida, Takayuki Shindo
  • Organizer: International Symposium of Aldosterone and Related ubstances in Hypertension
  • Place of Presentation: 仙台
• [Presentation] アドレノメデュリン-RAMP2システムは、小胞体ストレス誘導性細胞死を抑制し、腎保護的に働く (2013)
  • Author(s): 植竹龍一、桜井敬之、神吉昭子、河手久香、新藤優佳、吉沢隆浩、小山晃英、家里康弘、楊磊鳥山佑一、山内啓弘、五十嵐恭子、田中愛、柳田素子、新藤隆行
  • Organizer: 第8回臨床ストレス応答学会
  • Place of Presentation: 松本
• [Presentation] 脂肪細胞の代謝制御におけるアドレノメデュリン-RAMP2システムの意義 (2013)
  • Author(s): 神吉昭子、桜井敬之、新藤優佳、楊磊、植竹龍一、山内啓弘、五十嵐恭子、田中愛、河手久香、新藤隆行
  • Organizer: 第17回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] 慢性腎臓病におけるアドレノメデュリンーRAMP2システムの病態生理学的意義 (2012)
  • Author(s): 植竹龍一、桜井敬之、神吉明子、河手久香、新藤優佳、荒居琢磨、吉沢隆浩、小山晃英、家里康弘、楊磊、鳥山佑一、山内啓弘、五十嵐恭子、田中愛、新藤隆行
  • Organizer: 第41回日本心脈管作動物質学会
  • Place of Presentation: 秋田(ポスター)
• [Presentation] Roles of Adrenomedullin-RAMP2 System in Cardiac Mitochondrial Metabolism and Homeostasis (2012)
  • Author(s): Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Hayato Kawakami, Hiroki Nakanishi, Ryo Taguchi, Tsuyoshi Nakanishi, Takayuki Shindo
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Pathophysiological Significance of Adrenomedullin-RAMP2 System in Chronic Kidney Disease (2012)
  • Author(s): Ryuichi Uetake, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate, Takuma Arai, Yasuhiro Iesato, Takahiro Yoshizawa, Teruhide Koyama, Akihiro Yamauchi, Takayuki Shind
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Vascular Integrity Regulated by AM-RAMP2 System Contributes to Organ Protection (2012)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Takuma Arai, Yasuhiro Iesato, Yang Lei, Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Takayuki Shind
  • Organizer: 第76回日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] 心アドレノメデュリン-RAMP2システムによる心恒常性維持及び臓器保護作用 (2012)
  • Author(s): 吉沢隆浩,桜井敬之,神吉昭子,新藤優佳,小山晃英,植竹龍一,楊磊,川上速人,新藤隆
  • Organizer: 第85回日本内分泌学会
  • Place of Presentation: 名古屋
• [Presentation] アドレノメデュリンーRAMP2システムの腫瘍血管新生における意義 (2012)
  • Author(s): 田中愛、小山晃英、桜井敬之、神吉昭子、家里康弘、楊磊、吉沢隆浩、植竹龍一、谷口俊一郎、新藤隆行
  • Organizer: 第21回日本がん転移学会
  • Place of Presentation: 広島
• [Presentation] The maintenance of vascular homeostasis regulated by Adrenomedullin-RAMP2 system (2012)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Yasuhiro Iesato, Yang Lei, Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Takayuki Shindo
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡
• [Presentation] The significance of pathological angiogenesis in abdominal aortic aneurysm by adrenomedullin-RAMP2 system (2012)
  • Author(s): Megumu Tanaka, Ayano Okimura, Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Takuma Arai, Yasuhiro Iesato, Lei Yang, Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Takayuki Shindo
  • Organizer: 第44回日本動脈硬化学会
  • Place of Presentation: 福岡
• [Presentation] Vascular Endothelial Adrenomedullin-RAMP2 System is Essential for Vascular Integrity and Organ Homeostasis (2012)
  • Author(s): Teruhide Koyama, Laura Ochoa-Callejero, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Ichikawa-Shindo, Nobuyoshi Iinuma, Takuma Ara, Takahiro Yoshizawa, Yasuhiro Iesato, Yang Lei, Ryuichi Uetake, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Hisaka Kawate, Ralf H. Adams, Hayato Kawakami, Naoki Mochizuki, Alfredo Martínez, Takayuki Shindo
  • Organizer: 第35回日本高血圧学会総会
• [Presentation] Pathophysiological significance of Adrenomedullin-RAMP2 system in chronic kidney disease (2012)
  • Author(s): Ryuichi Uetake, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate, Yasuhiro Iesato, Takahiro Yoshizawa, Teruhide Koyama, Lei Yang, Yuichi Toriyama, Akihiro Yamauchi, Kyoko Igarashi, Megumu Tanaka, Takayuki Shindo
  • Organizer: 第29回国際心臓研究学会(ISHR)日本部会総会
  • Place of Presentation: 福岡
• [Presentation] 慢性腎臓病におけるアドレノメデュリン-RAMP2システムの病態生理学的意義 (2012)
  • Author(s): 植竹龍一桜井敬之神吉昭子新藤優佳河手久香荒居琢磨家里康弘吉沢隆浩小山晃英新藤隆行
  • Organizer: 第16回日本心血管内分泌代謝学会(CVEM2012)
  • Place of Presentation: 東京
• [Presentation] アドレノメデュリンによる心臓ミトコンドリア保護作用Adrenomedullin protects the heart against doxorubicin induced cardiomyopathy (2012)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、新藤優佳、小山晃英、植竹龍一、楊磊、新藤隆行
  • Organizer: 第16回日本心血管内分泌代謝学会
• [Presentation] 腫瘍血管新生におけるアドレノメデュリン-RAMP2システムの病態生理学的意義Pathophysiological roles of AM-RAMP2 system in tumor angiogenesis (2012)
  • Author(s): Megumu Tanaka, Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yasuhiro Iesato, Takahiro Yoshizawa, Yang Lei, Ryuichi Uetake, Akihiro Yamauchi, Takayuki Shindo
  • Organizer: 第16回日本心血管内分泌代謝学会
• [Presentation] 心臓における薬物誘発性ミトコンドリア障害に対するアドレノメデュリンの病態生理学的意義 (2012)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、新藤優佳、小山晃英、植竹龍一、新藤隆行
  • Organizer: 第8回日本ミトコンドリア学会
  • Place of Presentation: 東京
• [Presentation] ascular Integrity Regulated by AM-RAMP2 System Contributes to Organ Protection (2012)
  • Author(s): Koyama T et al.,
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Roles of Adrenomedullin-RAMP2 System in Cardiac Mitochondrial Metabolism and Homeostasis (2012)
  • Author(s): Yoshizawa et al.,
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] Pathophysiological Significance of Adrenomedullin-RAMP2 System in Chronic Kidney Disease (2012)
  • Author(s): Uetake R et al.,
  • Organizer: 日本循環器学会
  • Place of Presentation: 福岡
• [Presentation] アドレノメデュリン-RAMP2系による心臓エネルギー代謝制御と心機能維持 (2011)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、市川優佳、小山晃英、植竹龍一、楊磊、川上速人、中西広樹、田口良、中西豪、新藤隆行
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸
• [Presentation] Role of Adrenomedullin-RAMP2 system for vascular endothelial function (2011)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Takuma Arai, Yasuhiro Iesato, Lei Yang, Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Takayuki Shindo
  • Organizer: 内分泌サマーセミナー
  • Place of Presentation: 仙台
• [Presentation] Regulation of vascular endothelial integrity by adrenomedullin-RAMP2 system (2011)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Takuma Arai, Yasuhiro Iesato, Lei Yang, Takahiro Yoshizawa, Ryuichi Uetake, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Takayuki Shindo
  • Organizer: 第43回日本動脈硬化学会総会
  • Place of Presentation: 札幌
• [Presentation] Regulation of Vascular Integrity by Adrenomedullin-RAMP2 System (2011)
  • Author(s): Teruhide Koyama, Takayuki Sakurai , Akiko Kamiyoshi , Takuma Arai , Yuka Shindo , Takahiro Yoshizawa , Ryuichi Uetake , Lei Yang , Ayano Okimura , Akihiro Yamauchi , Megumu Tanaka , Takayuki Shindo
  • Organizer: 第75回日本循環器学会
• [Presentation] Adrenomedullin-RAMP2 signaling is essential for cardiac metabolism and homeostasis (2011)
  • Author(s): Takahiro Yoshizawa ,Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Hisaka Kawate Teruhide Koyama, Ryuichi Uetake Lei Yang, Akihiro Yamauchi, Ayano Okimura, Megumu Tanaka, Hayato Kawakami, Hiroki Nakanishi, Ryou Taguchi, Tsuyoshi Nakanishi, Takayuki Shindo
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] Novel metabolic regulations by adrenomedullin-RAMP2 system (2011)
  • Author(s): Akiko Kamiyoshi Takayuki Sakurai, Yuka Shindo, Teruhide Koyama, Takahiro Yoshizawa, Ryuichi Uetake, Lei Yang, Ayano Okimura, Akihiro Yamauchi, Megumu Tanaka, Hisaka Kawate, Tsuyoshi Nakanishi, Takayuki Shindo
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
• [Presentation] Novel metabolic regulations by adrenomedullin-RAMP2 system (2011)
  • Author(s): Akiko Kamiyoshi, Takayuki Sakurai, Yuka Shindo, Teruhide Koyama, Takahiro Yoshizawa, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Hisaka Kawate, Tsuyoshi Nakanishi, Takayuki Shindo
  • Organizer: American Heart Association, Scientific Sessions 2011
  • Place of Presentation: オーランド
• [Presentation] Adrenomedullin-RAMP2 system regulates vascular endothelial integrity (2011)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Takuma Arai, Takahiro Yoshizawa, Lei Yang, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Takayuki Shindo
  • Organizer: American Heart Association, Scientific Sessions 2011
  • Place of Presentation: オーランド
• [Presentation] Adrenomedullin-RAMP2 system is essential for cardiac homeostasis (2011)
  • Author(s): T. Yoshizawa, T. Sakurai, A. Kamiyoshi, Y. Shindo, H. Kawate, T. Koyama, R. Uetake, L. Yang, A. Yamauchi, M. Tanaka, K. Igarashi, H. Kawakami, H. Nakanishi, R. Taguchi, T. Nakanishi, T. Shindo
  • Organizer: American Heart Association, Scientific Sessions 2011
  • Place of Presentation: オーランド
• [Presentation] アドレノメデュリン-RAMP2システムは血管恒常性維持に必須であるAdrenomedullin-RAMP2 system is essential for maintenance of vascular homeostasis (2011)
  • Author(s): 小山晃英、桜井敬之、神吉昭子、新藤優佳、吉沢隆浩、楊磊、植竹龍一、山内啓弘、田中愛、新藤隆行
  • Organizer: 第15回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] アドレノメデュリン-RAMP2系の血管新生作用と腹部大動脈瘤における病態生理学的意義Angiogenic effect of adrenomedullin-RAMP2 system and its pathophysiological roles in Abdominal Aortic Aneurysm (2011)
  • Author(s): 田中愛、沖村綾乃、小山晃英、桜井敬之、神吉昭子、吉沢隆浩、揚磊、植竹龍一、山内啓弘、新藤隆行
  • Organizer: 第15回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] アドレノメデュリン-RAMP2系による心恒常性維持作用 (2011)
  • Author(s): 吉沢隆浩、桜井敬之、神吉昭子、市川優佳、小山晃英、川上速人、中西広樹、田口良、中西豪、新藤隆行
  • Organizer: 第15回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] 慢性腎臓病におけるアドレノメデュリン-RAMP2システムの病態生理学的意義の解明 (2011)
  • Author(s): 植竹龍一、桜井敬之神吉昭子新藤優佳荒居琢磨吉沢隆浩小山晃英家里康弘楊磊、新藤隆行
  • Organizer: 第15回日本心血管内分泌代謝学会
  • Place of Presentation: 大阪
• [Presentation] Novel regulation of cardiac metabolism and homeostasis by adrenomedullin-RAMP2 system (2011)
  • Author(s): Takahiro Yoshizawa, Takayuki Sakurai, Akiko Kamiyoshi, Yuka Shindo, Teruhide Koyama, Ryuichi Uetake, Lei Yang, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Hayato Kawakami, Hiroki Nakanishi, Ryou Taguchi, Tsuyoshi Nakanishi, Takayuki Shindo
  • Organizer: The 28th Annual Meeting of the International Society for Heart Research Japanese Section
  • Place of Presentation: 東京
• [Presentation] Adrenomedullin-RAMP2 system, as a novel regulator of vascular endothelial integrity (2011)
  • Author(s): Teruhide Koyama, Takayuki Sakurai, Akiko Kamiyoshi,Yuka Shindo, Takuma Arai, Yasuhiro Iesato, Lei Yang,Takahiro Yoshizawa, Ryuichi Uetake, Akihiro Yamauchi, Megumu Tanaka, Kyoko Igarashi, Yuichi Toriyama, Takayuki Shindo
  • Organizer: The 19th Annual Meeting of the Japanese Vascular Biology and Medicine Organization The 1st Asia-Pacific Vascular Biology Meeting
  • Place of Presentation: 東京
• [Presentation] Novel metabolic regulations by Adrenomedullin-RAMP2 system (2011)
  • Author(s): Kamiyoshi A, et al.
  • Organizer: American Heart Association
  • Place of Presentation: USA (Orlando)
• [Presentation] Novel metabolic regulations by Adrenomedullin-RAMP2 system (2011)
  • Author(s): Kamiyoshi A, et al.
  • Organizer: 第75回日本循環器学会
  • Place of Presentation: 横浜
• [Remarks]
  • URL: http://www7a.biglobe.ne.jp/~shindo/
• [Remarks] 信州大学大学院医学系研究科 博士課程 疾患予防医科学系専攻
  • URL: http://www.shinshu-u.ac.jp/graduate/medicine/doctoral/m-science/saisei.html
• [Remarks] 信州大学大学院医学系研究科循環病態学(旧:発生再生医学)
  • URL: http://www7a.biglobe.ne.jp/~shindo/
• [Remarks] 信州大学大学院医学系研究科 博士課程 疾患予防医科学系専攻
  • URL: http://www.shinshu-u.ac.jp/graduate/medicine/doctoral/m-science/saisei.html
• [Remarks] 信州大学大学院医学系研究科循環病態学（旧：発生再生医学)
  • URL: http://www7a.biglobe.ne.jp/~shindo/
• [Remarks]
  • URL: http://www.shinshu-u.ac.jp/graduate/medicine/doctoral/m-science/saisei.html
• [Remarks]
  • URL: http://www7a.biglobe.ne.jp/~shindo/