| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Receptor-activity-modifying protein (Ramp) 2 or 3 is a part of the Adrenomedullin (AM) receptor. The Ramps became suggested to be important for unique AM function. In this study, the role of Adrenomedullin-Ramp2, Ramp3 system were investigated in inflammatory conditions of the peritoneum and the colon, including pathological conditions of several organs (blood vessel, heart and kidney) by using Ramp2 conditional KO and Ramp3KO mice. It has revealed that Ramp2 is involved in supporting organ function, and Ramp3 plays a crucial role in inflammatory response. These results obtained suggest that the Ramps function independently of each other, however they make a coordinated response for maintaining organ homeostasis.
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