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Regulation of metabolic shift by drs tumor suppressor gene

Research Project

Project/Area Number 23590457
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionShiga University of Medical Science

Principal Investigator

TAMBE Yukihiro  滋賀医科大学, 医学部, 助教 (50283560)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords癌 / 代謝 / 癌抑制遺伝子 / メタボローム / グルコース代謝 / drs / 乳酸脱水素酵素 / エネルギー代謝 / ワールブルグ効果
Research Abstract

The drs gene is the tumor suppressor gene that regulates apoptosis and autophagy in cancer cells. However, its physiologic function in normal cells is unclear. In this study, by using drs knockout (KO) mouse embryonic fibroblast cells, we found that genetic loss of drs induces the metabolic shift toward aerobic glycolysis by increasing the expression and activity of lactose dehydrogenase (LDH). It is suggested that drs participates in the regulation of glucose metabolism and down-regulation of drs during tumorigenesis is involved in the induction of Warburg effect in human cancers. We also found that the induction of drs into KO cells and the treatment of cancer cells with LDH inhibitor could suppress the metabolic shift and the malignant transformation. Further investigations will contribute toward developing a new anticancer therapy.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (25 results)

All 2014 2013 2012 2011 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (18 results) Remarks (3 results)

  • [Journal Article] Female-specific rectal carcinogenesis in cyclin D1b transgenic mice.2014

    • Author(s)
      Tambe, Y., Kim, C. J., Munkaisho, K., Sugihara, H., Isono, T., Sonoda, H., Shimizu, T., Kondoh, G., Inoue, H.
    • Journal Title

      Carcinogenesis

      Volume: 35 Issue: 1 Pages: 227-236

    • DOI

      10.1093/carcin/bgt293

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway2012

    • Author(s)
      Tambe, Y., et al
    • Journal Title

      Cancer Letters

      Volume: 314 Issue: 1 Pages: 82-91

    • DOI

      10.1016/j.canlet.2011.09.015

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of viral replication by drs tumor suppressor via mTOR dependent pathway.2012

    • Author(s)
      Tambe Y, Okuyama N, Nakagawa T, Muramoto A, Hasebe M, Chano T, Inoue H.
    • Journal Title

      Cancer Lett.

      Volume: 314 Pages: 82-91

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Opposite regulation of epitnelial-to mesenchymal transition and cell invasiveness by periostin between prostate and bladder cance cells2011

    • Author(s)
      Kim, C.J., et al
    • Journal Title

      Int.J.One.

      Volume: 38 Pages: 1759-1766

    • DOI

      10.3892/ijo.2011.997

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Molecular mechanism of female specific rectal carcinogenesis in cyclin D1b transgenic mice2013

    • Author(s)
      Yukihiro Tambe, Chul Jang Kim, Ken ichi Mukaisho, Hiroyuki Sugihara, Hirokazu Inoue
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular mechanism of the regulation of Warburg effect by the drs tumor suppressor gene2013

    • Author(s)
      Yukihiro Tambe, Hirokazu Inoue
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Molecular mechanism of female specific rectal carcinogenesis in cyclin D1b transgenic mice2013

    • Author(s)
      Chul Jang Kim, Yukihiro Tambe, Ken ichi Mukaisho, Hiroyuki Sugihara, Hirokazu Inoue
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-05
    • Related Report
      2013 Final Research Report
  • [Presentation] drs がん抑制遺伝子による Warburg 効果制御の分子機構2013

    • Author(s)
      旦部幸博、井上寛一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cyclin D1b トランスジェニックマウスにおける雌特異的直腸腫瘍 発生の分子機構の解析2013

    • Author(s)
      金哲將、旦部幸博、向所賢一、杉原洋行、井上寛一
    • Organizer
      第72回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Cyclin D1bトランスジェニックマウスにおける雌特異的直腸腫瘍発生の分子機構2013

    • Author(s)
      旦部幸博、金哲將、向所賢一、杉原洋行、井上寛一
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Drs tumor suppressor gene is involved in regulation of Warburg effect2012

    • Author(s)
      Masahiro Hasebe, Akitsugu Yamamoto, Yukihiro Tambe, Hirokazu Inoue
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Female specific development of rectal cancers via serrated pathway in cyclin D1b transgenic mice2012

    • Author(s)
      Yukihiro Tambe, Chul Jang Kim, Ken ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Hiromichi Sonoda, Tomoharu Shimizu, Gen Kondoh, Hirokazu Inoue
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo and in vitro oncogenic potential of human cyclin D1b variant2012

    • Author(s)
      Hirokazu Inoue, Yukihiro Tambe, Ken ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Gen Kondoh, Chul Jang Kim
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] The drs tumor suppressor gene is involved in regulation of Warburg effect2012

    • Author(s)
      Yukihiro Tambe, Hirokazu Inoue
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Studies on the oncogenic potential of rectal tumor developed in cyclic D1b transgenic mice2012

    • Author(s)
      Chul Jang Kim, Yukihiro Tambe, Ken ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Gen Kondoh, Hirokazu Inoue
    • Organizer
      第71回日本癌学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] The drs tumor suppressor gene is involved in regulation of Warburg effect2012

    • Author(s)
      Yukihiro Tambe, Hirokazu Inoue.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Studies on the oncogenic potential of rectal tumor developed in cyclic D1b transgenic mice2012

    • Author(s)
      Chul Jang Kim, Yukihiro Tambe, Ken-ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Gen Kondoh, Hirokazu Inoue.
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] In vivo and in vitro oncogenic potential of human cyclin D1b variant2012

    • Author(s)
      Hirokazu Inoue, Yukihiro Tambe, Ken-ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Gen Kondoh, Chul Jang Kim
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report
  • [Presentation] Female-specific development of rectal cancers via serrated pathway in cyclin D1b-transgenic mice2012

    • Author(s)
      Yukihiro Tambe, Chul Jang Kim, Ken-ichi Mukaisho, Hiroyuki Sugihara, Takahiro Isono, Hiromichi Sonoda, Tomoharu Shimizu, Gen Kondoh, Hirokazu Inoue
    • Organizer
      第35回分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Role of the drs tumor suppressor in regulation of energy metabolism2011

    • Author(s)
      Yukihiro Tambe, Hirokazu Inoue
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of cyclin D1b variant in rectal tumorigenesis2011

    • Author(s)
      Chul Jang Kim, Yukihiro Tambe, Takahiro Isono, Ken ichi Mukaisho, Hiroyuki Sugihara, Gen Kondoh, Hirokazu Inoue
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Roll of the drs tumor suppressor in regulation of energy metabolism2011

    • Author(s)
      Yukihiro Tambe, Hirokazu Inoue.
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.shigamed.ac.jp/~hqmicro/

    • Related Report
      2013 Final Research Report
  • [Remarks] 滋賀医大病理学講座微生物感染症学部門

    • URL

      http://www.shiga-med.ac.jp/~hqmicro/

    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.shiga-med.ac.jp/~hqmicro/

    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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