| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We analyzed the inhibitory mechanisms of angiogenesis by using three groups of molecule, including artificial compounds, physiological cytokine, and inhibitory antibody. Neuropilin-1 is a cell surface receptor of VEGF. We showed that sulfate polysaccharide, fucoidan, and oligo-guanosine nucleotide could internalize Neuropilin-1 from the endothelial cell surface to lysosome as an "internalization-inducer". Moreover, we showed that fucoidan and oligo-guanosine nucleotide could inhibit angiogenesis in vivo. We analyzed the interaction of a cytokine VEGF-B with FGF receptor. We proposed the possibility that VEGF-B works as an antagonist of FGF receptor. And we analyzed the biochemical property of the antibody against the members of Ephrin family that are recently identified to have a role in angiogenesis.
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