| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
The purpose of this study is to identify chemopreventive compounds that inhibit inflammation-related carcinogenesis. Inflammation-related carcinogenesis is initiated by massive infiltration of inflammatory cells into an inflamed lesion. I found several compounds that inhibit the infiltration by using in vitro screening model. Among them, I found that a compound had the strongest inhibitory effects on the inflammatory cell infiltration, and that it inhibited foreign body-induced inflammation-related carcinogenesis in a mouse model. DNA array revealed that expressions of inflammation-related molecules such as NF-kB-related molecules were inhibited. Then, I determined minimum structure of the compound that will be responsible for the inhibition of inflammation.
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