Detection of effective compounds for inhibiting inflammation-related carcinogenesis

• Project/Area Number: 23590461
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Tottori University
• Principal Investigator: OKADA Futoshi 鳥取大学, 医学部, 教授 (00250423)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 炎症発癌 / 化合物 / 炎症細胞 / 阻害化合物 / 発癌予防 / 浸出阻止

Research Abstract

The purpose of this study is to identify chemopreventive compounds that inhibit inflammation-related carcinogenesis. Inflammation-related carcinogenesis is initiated by massive infiltration of inflammatory cells into an inflamed lesion. I found several compounds that inhibit the infiltration by using in vitro screening model. Among them, I found that a compound had the strongest inhibitory effects on the inflammatory cell infiltration, and that it inhibited foreign body-induced inflammation-related carcinogenesis in a mouse model. DNA array revealed that expressions of inflammation-related molecules such as NF-kB-related molecules were inhibited. Then, I determined minimum structure of the compound that will be responsible for the inhibition of inflammation.

Research Products

• [Journal Article] Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis (2014)
  • Author(s): Kanda Y, Kawaguchi T, Kuramitsu Y, Kitagawa T, Kobayashi T, Takahashi N, Tazawa H, Habelhah H, Hamada J-I, Kobayashi M, Hirahata M, Onuma K, Osaki M, Nakamura K, Kitagawa T, Hosokawa M and Okada F.
  • Journal Title: Proteomics Volume: 14 Issue: 9 Pages: 1031-1041
  • DOI: 10.1002/pmic.201300414
  • Peer Reviewed
• [Journal Article] PITX1 is reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia (2014)
  • Author(s): Nakabayashi M, Osaki M, Kodani I, Okada F, Ryoke K, Oshimura M, Ito H and Kugoh H
  • Journal Title: Oncol Lett Volume: 7(PMID :24527083) Pages: 750-754
• [Journal Article] Proteomic analysis indicates that overexpression and nuclear translocation of lactoylglutathione lyase (GLO1) is associated with tumor progression in murine fibrosarcoma (2014)
  • Author(s): Wang Y, Kuramitsu Y, Tokuda K, Okada F, Baron B, Akada J, Kitagawa T, Nakamura K.
  • Journal Title: Electrophoresis Volume: 印刷中 Issue: 15 Pages: 3661-3665
  • DOI: 10.1002/elps.201300497
  • Peer Reviewed
• [Journal Article] Serum miR-210 as a potential biomarker of early clear cell renal cell carcinoma (2014)
  • Author(s): Iwamoto H, Kanda Y, Sejima T, Osaki M, Okada F and Takenaka A.
  • Journal Title: Int J Oncol Volume: 44 Issue: 1 Pages: 53-58
  • DOI: 10.3892/ijo.2013.2169
  • Peer Reviewed
• [Journal Article] PITX1 is reliable biomarker for predicting prognosis in patients with oral epithelial dysplasia (2014)
  • Author(s): Nakabayashi M, Osaki M, Kodani I, Okada F, Ryoke K, Oshimura M, Ito H and Kugoh H.
  • Journal Title: Oncol Lett Volume: 7 Issue: 3 Pages: 750-754
  • DOI: 10.3892/ol.2013.1775
  • Peer Reviewed
• [Journal Article] Chronic inflammation-derived nitric oxide causes conversion of human colonic adenoma cells into adenocarcinoma cells (2013)
  • Author(s): Tazawa H, Kawaguchi T, Kobayashi T, Kuramitsu Y, Wada S, Satomi Y, Nishino H, Kobayashi M, Kanda Y, Osaki M, Kitagawa T, Hosokawa M and Okada F
  • Journal Title: Exp Cell Res Volume: 319 Issue: 18 Pages: 2835-2844
  • DOI: 10.1016/j.yexcr.2013.08.006
  • Peer Reviewed
• [Journal Article] Enhanced expression of cystine/glutamate transporter in the lung caused by the oxidative stress-inducing agent paraquat (2012)
  • Author(s): Sho Kobayashi
  • Journal Title: Free Radic Biol Med Volume: 53 Issue: 12 Pages: 2197-2203
  • DOI: 10.1016/j.freeradbiomed.2012.09.040
  • Peer Reviewed
• [Journal Article] Prognostic significance of sirtuin 2 protein nuclear localization in glioma: an immunohistochemical study (2012)
  • Author(s): Imaoka N, Hiratsuka M, Osaki M, Kamitani H, Kambe A, Fukuoka J, Kurimoto M, Nagai S, Okada F, Watanabe T, Ohama E, Kato S, Oshimura M
  • Journal Title: Oncol. Rep Volume: 28 Issue: 3 Pages: 923-930
  • DOI: 10.3892/or.2012.1872
  • Peer Reviewed
• [Journal Article] Involvement of regulatory T cells in Toll-like receptor 2-mediated anti- and pro-tumor activities of the mycoplasmal lipopeptide FSL-1 (2011)
  • Author(s): Kiura K, Hasebe A, Iyori M, Okada F, Yasuda M, Shamsul HM, Ohtani M, Totsuka Y, Wakita M and Shibata K
  • Journal Title: Immunobiology Volume: 216 (8) Issue: 8 Pages: 891-900
  • DOI: 10.1016/j.imbio.2011.02.006
• [Journal Article] Development of a Quantitative Bioassay to Assess Preventive Compounds against Inflammation-based Carcinogenesis (2011)
  • Author(s): Kunishige Onuma, Yuka Suenaga, Ryuta Sakaki, Satoshi Yoshitome, Yu Sato, Satomi Ogawara, Saori Suzuki, Mitsuhiro Kuramitsu, Hidekatsu Yokoyama, Akira Murakami, Junichi Hamada, Garth L Nicolson, Masanobu Kobayashi, Junichi Fujii, Futoshi Okada
  • Journal Title: Nitric Oxide Volume: 25 Issue: 2 Pages: 183-194
  • DOI: 10.1016/j.niox.2011.02.003
  • Peer Reviewed
• [Journal Article] Involvement of regulatory T cells in Toll-like receptor 2-mediated anti- and pro-tumor activities of the mycoplasmal lipopeptide FSL-1 (2011)
  • Author(s): Kiura K et al.
  • Journal Title: Immunobiology Volume: 216 Pages: 891-900
  • Peer Reviewed
• [Journal Article] Two-dimensional gel electrophoresis using immobilized pH gradient strips and flamingo fluorescent gel stain identified non-nuclear proteins possibly related to malignant tumour progression (2011)
  • Author(s): Kuramitsu Y et al.
  • Journal Title: Anticancer Res Volume: 31 Pages: 1259-1263
  • Peer Reviewed
• [Presentation] 炎症浸出の阻害化合物探索による炎症発癌の抑制 (2013)
  • Author(s): 岡田太
  • Organizer: 第86回日本生化学会
  • Place of Presentation: パシフィコ横浜,横浜(プログラム号85 (8): p125)
  • Year and Date: 2013-09-11
• [Presentation] 炎症発癌の遮断に向けた化合物の実効性の検証 (2013)
  • Author(s): 小沼邦重,池田多津世,末永裕佳,神田裕介,小林正伸,尾﨑充彦,岡田太
  • Organizer: 第66回日本酸化ストレス学会学術集会
  • Place of Presentation: ウインクあいち,名古屋(プログラム・抄録集,p57)
  • Year and Date: 2013-06-13
• [Presentation] 炎症発癌を遮断する阻害化合物探索 (2013)
  • Author(s): 池田多津世,末永裕佳,神田裕介,小沼邦重,尾﨑充彦,岡田太
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌,札幌(日本病理学会会誌p491(SP3-2))
  • Year and Date: 2013-06-08
• [Presentation] 炎症発癌を標的とする阻害化合物探索と実効性評価 (2013)
  • Author(s): 池田多津世,末永裕佳,神田裕介,小沼邦重,尾﨑充彦,岡田太
  • Organizer: 平成24年度文部科学省科学研究費補助金新学術領域研究「がん研究等の特性を踏まえた支援活動」平成24年度「個体レベルでのがん研究支援活動」ワークショップ:個体レベルのがん研究による相乗効果:学際的インターラクションから創造へ
  • Place of Presentation: 琵琶湖ホテル,大津市(プログラム・抄録集,p70)
  • Year and Date: 2013-02-07
• [Presentation] 炎症発癌を遮断する阻害化合物探索 (2013)
  • Author(s): 池田多津世，末永裕佳，神田裕介，小沼邦重，尾﨑充彦，岡田 太
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: ロイトン札幌
• [Presentation] 炎症浸出の阻害化合物探索による炎症発癌の抑制 (2013)
  • Author(s): 岡田 太
  • Organizer: 第86回日本生化学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 炎症発癌を標的とする阻害化合物探索と実効性評価 (2013)
  • Author(s): 岡田 太 その他
  • Organizer: 平成24年度文部科学省科学研究費補助金新学術領域研究「がん研究等の特性を踏まえた支援活動」平成24年度「個体レベルでのがん研究支援活動」ワークショップ
  • Place of Presentation: 大津市
• [Presentation] 低酸素再酸素化環境と発癌・悪性化の進展 (2011)
  • Author(s): 岡田太
  • Organizer: 平成23年度北海道大学遺伝子病制御研究所共同研究集会
  • Place of Presentation: 北海道大学医学部フラテホール,札幌市
  • Year and Date: 2011-09-06
  • Invited
• [Presentation] 発酵玄米によるマウス炎症発がんの予防 (2011)
  • Author(s): 岡田太
  • Organizer: 第18回日本がん予防学会学術集会
  • Place of Presentation: 京都府立医科大学図書館ホール,京都市(ポスターディスカッション)
  • Year and Date: 2011-06-20
• [Presentation] 低酸素再酸素化環境と発癌・悪性化の進展 (2011)
  • Author(s): 岡田 太
  • Organizer: 平成23年度北海道大学遺伝子病制御研究所共同研究集会(招待講演)
  • Place of Presentation: 北海道大学医学部フラテホール（札幌市）
• [Presentation] 発酵玄米によるマウス炎症発がんの予防 (2011)
  • Author(s): 岡田 太 ほか
  • Organizer: 第18回 日本がん予防学会学術集会
  • Place of Presentation: 京都府立医科大学図書館ホール（京都市）
• [Book] Inflammation as a niche for tumor progression. In : Cancer and Inflammation Mechanisms : Chemical, Biological, and Clinical Aspects (2014)
  • Author(s): Okada F, (Eds. Y Hiraku, S Kawanishi and H Ohshima)
  • Publisher: John Wiley & Sons, Inc.
• [Book] Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical (2013)
  • Author(s): Okada F
  • Publisher: John Wiley & Sons
• [Book] How aging and cellular senescence influence metastasis. In : Cancer Metastasis : biologic basis and therapeutic (2011)
  • Author(s): Okada F and Kobayashi H, (Eds. D Lyden, DR Welch and B Psaila)
  • Publisher: Cambridge University Press
• [Remarks]
  • URL: http://byoutaiseikagaku.jimdo.com/
• [Remarks] 鳥取大学医学部病態生化学分野研究内容
  • URL: http://byoutaiseikagaku.jimdo.com/%E7%A0%94%E7%A9%B6%E5%86%85%E5%AE%B9/