Pathological analysis of chronic active EBV-infection rabbit model with hemophagocytosis
Project/Area Number |
23590463
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Tottori University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | EBVの感染モデル / ウサギモデル / EBNA2遺伝子欠損型EBV / ワクチン / EBNA-2遺伝子欠損型のEBV / EBV / うさぎ / ウサギ |
Research Abstract |
1) EBER-1 ISH revealed EBV-positive and -negative rabbits lifelong observation after EBV-inoculation. 2) EBNA-2-deleted EBV from P3HR-1 can infect rabbits with lower efficacy than prototype EBV from B85-8. However, this is the only one in vivo system to study the function of EBNA-2 gene. 3) Synthetic peptides of Epstein-Barr Virus-major envelope glycoprotein-350/220 do not prevent infection in a rabbit Epstein-Barr Virus infection model.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Hayashi EBNA-2-deleted Epstein–Barr virus from P3HR-1 can infect rabbits with lower efficiency than prototype Epstein–Barr virus from B95-82013
Author(s)
H. Sano, K. Nagata, K. Kato, K. Kanai, K. Yamamoto, K. Okuno, S. Kuwamoto, H. Higaki-Mori, H. Sugihara, M. Kato, I. Murakami, S. Kanzaki, K
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Journal Title
Intervirology
Volume: 56
Pages: 114-121
Related Report
Peer Reviewed
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[Journal Article] EBNA-2-deleted Epstein–Barr virus from P3HR-1 can infect rabbits with lower efficiency than prototype Epstein–Barr virus from B95-82013
Author(s)
Hitoshi Sano, Keiko Nagata, Kaoru Kato, Kyousuke Kanai, Kiyoshige Yamamoto, Keisuke Okuno, Satoshi Kuwamoto, Hiromi Higaki-Mori, Hirotsugu Sugihara, Masako Kato, Ichiro Murakami, Susumu Kanzaki, and Kazuhiko Hayashi
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Journal Title
Intervirology
Volume: 56:
Pages: 114-12
Related Report
Peer Reviewed
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[Journal Article] In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen2011
Author(s)
Kyosuke Kanai, Kaoru Kato, Hitoshi, Sano, Keiko Nagata, Keisuke Okuno, Satoshi Kuwamoto, Hiromi Higaki, Hirotsugu Sugihara, Masako Kato, Ichiro Murakami, Kazuhiko Hayashi
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Journal Title
Intervirology
Volume: 54
Pages: 17-24
Related Report
Peer Reviewed
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[Journal Article] In Vitro EBV infection Model of Rabbit Lymphocytes from Peripheral Blood or Spleen.2011
Author(s)
Kyosuke Kanai1,4, Kaoru Kato1,2, Hitoshi Sano1,3, Keiko Nagata1, Keisuke Okuno1,3,Satoshi Kuwamoto1, Hiromi Higaki1, Hirotsugu Sugihara1, Masako Kato1, Ichiro Murakami1, Kazuhiko Hayashi1
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Journal Title
Intervirology
Volume: 54
Pages: 17-24
Related Report
Peer Reviewed
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[Presentation] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection2011
Author(s)
Hayashi K, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
Organizer
23rd European Congress of Pathology
Place of Presentation
Helsinki Exhibition & Convention Centre, Helsinki, Finland
Year and Date
2011-08-31
Related Report
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[Presentation] A rabbit model for primary and lifelong persistent Epstein-Barr virus infection.2011
Author(s)
K Hayashi, K Takashima, K Okuno, K. Kato, S Sano, H Sugihara, M Kato, I Murakami K, K Nagata
Organizer
23rd European Congress of Pathology
Place of Presentation
Helsinki Exhibition & Convention Centre, Helsinki, Finland
Year and Date
2011-08-31
Related Report
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