Analysis of gliomagenesis using novel mouse glioma model

• Project/Area Number: 23590465
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Kyushu University
• Principal Investigator: MARUMOTO Tomotoshi 九州大学, 生体防御医学研究所, 准教授 (60363511)
• Co-Investigator(Kenkyū-buntansha): TANI Kenzaburo 九州大学, 生体防御医学研究所, 教授 (00183864)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 脳腫瘍 / 膠芽腫 / 実験病理学 / 腫瘍

Research Abstract

Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. However the cellular origin of this tumor has not been well understood. We showed that GBM can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice could give rise to GBM. These data will help understand the gliomagenesis and contribute to the development of the new strategy of treatment.

Research Products

• [Journal Article] Characterization of common marmoset dysgerminoma like tumor induced by the lentiviral expression of reprogramming factors. (2014)
  • Author(s): Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K
  • Journal Title: Cancer Sci. Volume: 105 Issue: 4 Pages: 402-408
  • DOI: 10.1111/cas.12367
  • Peer Reviewed
• [Journal Article] Analysis of essential pathways for self-renewal in common marmoset embryonic stem cells (2014)
  • Author(s): Nii T, Marumoto T, Kawano H, Yamaguchi S, Liao J, Okada M, Sasaki E, Miura Y, Tani K
  • Journal Title: FEBS Open Bio Volume: 4(equal contribution) Pages: 213-9
• [Journal Article] Analysis of essential pathways for self-renewal in common marmoset embryonic stem cells. (2014)
  • Author(s): Nii T, Marumoto T, Kawano H, Yamaguchi S, Liao J, Okada M, Sasaki E, Miura Y, Tani K
  • Journal Title: FEBS Open Bio. Volume: 4 Issue: 1 Pages: 213-219
  • DOI: 10.1016/j.fob.2014.02.007
  • Peer Reviewed
• [Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells (2013)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K
  • Journal Title: Mol Ther. Volume: 6(equal contribution) Pages: 1242-50
• [Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells. (2013)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamoto S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y and Tani K
  • Journal Title: Molecular Therapy Volume: in press Issue: 6 Pages: 1242-1250
  • DOI: 10.1038/mt.2013.60
  • Peer Reviewed
• [Journal Article] Dedifferentiation of neurons and astrocytes by oncogenes can induce glioblastomas (2012)
  • Author(s): Friedmann-Morvinski D, Bushong E, Ke E, Soda Y, Marumoto T, Singer O, Ellisman M and Verma IM
  • Journal Title: Science Volume: 338 Pages: 1080-4
• [Journal Article] Dedifferentiation of neurons and astrocytes by oncogenes can induce glioblastomas. (2012)
  • Author(s): Friedmann-Morvinski D, Bushong E, Ke E, Soda Y, Marumoto T, Singer O, Ellisman M and Verma IM.
  • Journal Title: Science Volume: 338 Issue: 6110 Pages: 1080-1084
  • DOI: 10.1126/science.1226929
  • Peer Reviewed
• [Journal Article] Roles of p53 in various biological aspects of hematopoietic stem cells. (2012)
  • Author(s): Nii T, Marumoto T, Tani K.
  • Journal Title: Journal of Biomedicine and Biotechnology Volume: 2012 Pages: 1-10
  • DOI: 10.1155/2012/903435
  • Peer Reviewed
• [Journal Article] Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties that Is Active Against Lung Adenocarcinoma (2012)
  • Author(s): Miyamoto S, Inoue H, Nakamura T, Yamada M, Sakamoto C, Urata Y, Okazaki T, Marumoto T, Takahashi A, Takayama K, Nakanishi Y, Shimizu H, Tani K
  • Journal Title: Cancer Research Volume: (掲載確定)(印刷中) Issue: 10 Pages: 2609-2621
  • DOI: 10.1158/0008-5472.can-11-3185
  • Peer Reviewed
• [Journal Article] Molecular biology of glioma. (2012)
  • Author(s): Marumoto T and Saya H.
  • Journal Title: Adv Exp Med Biol. Volume: 746 Pages: 2-11
  • DOI: 10.1007/978-1-4614-3146-6_1
  • ISBN: 9781461431459, 9781461431466
• [Journal Article] Development of novel immune therapies for solid tumors: phase I clinical trials in a single institute (2012)
  • Author(s): Hijikata Y, Murahashi-Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K.
  • Journal Title: Rinsho Ketsueki. Volume: 53 Pages: 487-492
  • NAID: 130004501683
  • Peer Reviewed
• [Presentation] 新規脳腫瘍マウスモデルを用いた膠芽腫発生機構の解明 (2013)
  • Author(s): 丸本朋稔
  • Organizer: 山口大学医学部 第10回器官解剖学セミナー
  • Place of Presentation: 宇部
  • Invited
• [Presentation] 塩化ナトリウム内服で改善した中枢性塩類喪失症候群（Cerebral Salt Wasting Syndrome: CSWSの1例 (2013)
  • Author(s): 宮原 裕, 村橋睦了, 山田一成, 土方康基, 井上博之, 丸本朋稔, 松田めぐみ＊, 谷 憲三朗
  • Organizer: 第300回日本内科学会九州地方会
  • Place of Presentation: 福岡
• [Presentation] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells (2012)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y and Tani K
  • Organizer: The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium
  • Place of Presentation: 福岡
• [Presentation] 小型霊長類マーモセットES細胞への遺伝子導入による造血幹細胞分化系の確立 (2012)
  • Author(s): 丸本朋稔、河野紘隆、二井偉暢、谷憲三朗
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 新規マウス膠芽腫モデルの作出と治療への応用 (2012)
  • Author(s): 丸本朋稔
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Novel mouse glioma model using Cre-controlled lentiviral vectors provides a better understanding of gliomagenesis. (2012)
  • Author(s): Tomotoshi Marumoto, Yasushi Soda, Dinohrah Friedmann-Morvinski, Hiroyuki Michiue and Inder M. Verma
  • Organizer: 19th International Brain Tumor Research and Therapy Conference
  • Place of Presentation: Niagara Falls, Canada
  • Invited
• [Presentation] Efficient hematopoietic differentiation of common marmoset embryonic stem cells by the inhibition of PI3K-AKT pathway (2012)
  • Author(s): Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani
  • Organizer: 第18回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] CHARACTERIZATION OF COMMON MARMOSET DYSGERMINOMA-LIKE TUMORS GENERATED BY THE TRANSDUCTION OF REPROGRAMMING FACTORS (2012)
  • Author(s): Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Shinji Okano, et. al.
  • Organizer: 第18回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] HIGHLY EFFICIENT GENERATION OF INDUCED PLURIPOTENT STEM CELLS BY THE INHIBITION OF PTEN TUMOR SUPPRESSOR (2012)
  • Author(s): Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Yoko Nagai, Michiyo Okada, et.al.
  • Organizer: 第18回日本遺伝子治療学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] EFFICIENT HEMATOPOIETIC DIFFERENTIATION OF COMMON MARMOSET EMBRYONIC STEM CELLS BY THE INHIBITION OF PI3K-AKT PATHWAY (2012)
  • Author(s): Takenobu Nii, Tomotoshi Marumoto, Hirotaka Kawano, Saori Yamaguchi, Yoko Nagai, Yoshie Miura, Jiyuan Liao, Michiyo Okada, Kenzaburo Tani
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
• [Presentation] Efficient generation of induced pluripotent stem cells by the use of Pten inhibitor (2012)
  • Author(s): Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Nagai Y, Okada M, Miura Y, Shimoda S, Inoue H, Takahashi A, et al.
  • Organizer: International Society for Stem Cell Research 10th Annual Meeting
  • Place of Presentation: 横浜
• [Presentation] A phase I study of adoptive immunotherapy using autologous dendritic cell pulsed with a RNF43 peptide in patients with advanced solid tumors (2012)
  • Author(s): 土方 康基、岡崎 利彦、田中 芳浩、小林 慎一、村橋 睦了、山田 一成、丸本 朋稔、井 上 博之、谷 憲三
  • Organizer: 第4回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: 金沢
• [Presentation] Multipeptide immune responses to cancer vaccine after cyclophosphamide correlated with longer survival of the patients with advanced solid tumors (2012)
  • Author(s): 村橋 睦了、土方 康基、田中 芳浩、岸本 淳司、井上 博之、丸本 朋稔、高橋 淳、岡崎 利 彦、平川 雅和、岡野 慎士、谷 憲三朗
  • Organizer: 第4回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: 金沢
• [Presentation] Coxsackievirus B3 is an immunostimulatory oncolytic virus active against lung adenocarcinoma (2012)
  • Author(s): Shohei Miyamoto, Hiroyuki Inoue, Beibei Wang, Keisuke Yasunari, Takafumi Nakamura, Meiko Yamada, Yasuo Urata, Tomotoshi Marumoto, et. al.
  • Organizer: American Association of Cancer Research, 103th Annual Meeting
  • Place of Presentation: Chicago
• [Presentation] PTEN機能抑制による高効率人工多能性幹細胞作製法 (2012)
  • Author(s): 丸本 朋稔、 廖 紀元、 山口 沙織、 岡野 慎士、 竹田 直樹、 三浦 由恵、 二井 偉暢、 坂本 千香、 河野 紘隆、 永井 陽子、 河原 康一、 鈴木 聡、 谷 憲三朗
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Book] Japanese Scientists in Science 2012 (2013)
  • Author(s): 曽田泰、丸本朋稔
  • Total Pages: 1
  • Publisher: American Association for the Advancement of Science (AAAS)