Analysis of gliomagenesis using novel mouse glioma model
| Project/Area Number |
23590465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANI Kenzaburo 九州大学, 生体防御医学研究所, 教授 (00183864)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳腫瘍 / 膠芽腫 / 実験病理学 / 腫瘍 |
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| Research Abstract |
Glioblastoma multiforme (GBM) is the most malignant primary brain tumor in adults. However the cellular origin of this tumor has not been well understood. We showed that GBM can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice could give rise to GBM. These data will help understand the gliomagenesis and contribute to the development of the new strategy of treatment.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] Characterization of common marmoset dysgerminoma like tumor induced by the lentiviral expression of reprogramming factors.2014
Author(s)
Yamaguchi S, Marumoto T, Nii T, Kawano H, Liao J, Nagai Y, Okada M, Takahashi A, Inoue H, Sasaki E, Fujii H, Okano S, Ebise H, Sato T, Suyama M, Okano H, Miura Y, Tani K
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Journal Title
Cancer Sci.
Volume: 105
Issue: 4
Pages: 402-408
DOI
Related Report
Peer Reviewed
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[Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells2013
Author(s)
Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y, Tani K
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Journal Title
Mol Ther.
Volume: 6(equal contribution)
Pages: 1242-50
Related Report
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[Journal Article] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells.2013
Author(s)
Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamoto S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y and Tani K
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Journal Title
Molecular Therapy
Volume: in press
Issue: 6
Pages: 1242-1250
DOI
Related Report
Peer Reviewed
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[Journal Article] Coxsackievirus B3 Is an Oncolytic Virus with Immunostimulatory Properties that Is Active Against Lung Adenocarcinoma2012
Author(s)
Miyamoto S, Inoue H, Nakamura T, Yamada M, Sakamoto C, Urata Y, Okazaki T, Marumoto T, Takahashi A, Takayama K, Nakanishi Y, Shimizu H, Tani K
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Journal Title
Cancer Research
Volume: (掲載確定)(印刷中)
Issue: 10
Pages: 2609-2621
DOI
Related Report
Peer Reviewed
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[Journal Article] Development of novel immune therapies for solid tumors: phase I clinical trials in a single institute2012
Author(s)
Hijikata Y, Murahashi-Iga M, Okazaki T, Tanaka Y, Odaira K, Okano S, Hisano T, Takahashi A, Marumoto T, Inoue H, Tani K.
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Journal Title
Rinsho Ketsueki.
Volume: 53
Pages: 487-492
NAID
Related Report
Peer Reviewed
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[Presentation] Inhibition of PTEN tumor suppressor promotes the generation of induced pluripotent stem cells2012
Author(s)
Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Miyamato S, Nagai Y, Okada M, Inoue H, Kawahara K, Suzuki A, Miura Y and Tani K
Organizer
The 21st Hot Spring Harbor Symposium jointly with 9th Global COE International Symposium
Place of Presentation
福岡
Related Report
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[Presentation] CHARACTERIZATION OF COMMON MARMOSET DYSGERMINOMA-LIKE TUMORS GENERATED BY THE TRANSDUCTION OF REPROGRAMMING FACTORS2012
Author(s)
Saori Yamaguchi, Tomotoshi Marumoto, Takenobu Nii, Hirotaka Kawano, Jiyuan Liao, Yoko Nagai, Michiyo Okada, Atsushi Takahashi, Hiroyuki Inoue, Erika Sasaki, Shinji Okano, et. al.
Organizer
第18回日本遺伝子治療学会年次学術集会
Place of Presentation
熊本
Related Report
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[Presentation] HIGHLY EFFICIENT GENERATION OF INDUCED PLURIPOTENT STEM CELLS BY THE INHIBITION OF PTEN TUMOR SUPPRESSOR2012
Author(s)
Jiyuan Liao, Tomotoshi Marumoto, Saori Yamaguchi, Shinji Okano, Naoki Takeda, Chika Sakamoto, Hirotaka Kawano, Takenobu Nii, Yoko Nagai, Michiyo Okada, et.al.
Organizer
第18回日本遺伝子治療学会年次学術集会
Place of Presentation
熊本
Related Report
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[Presentation] Efficient generation of induced pluripotent stem cells by the use of Pten inhibitor2012
Author(s)
Liao J, Marumoto T, Yamaguchi S, Okano S, Takeda N, Sakamoto C, Kawano H, Nii T, Nagai Y, Okada M, Miura Y, Shimoda S, Inoue H, Takahashi A, et al.
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
横浜
Related Report
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