| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
|
|---|
| Research Abstract |
gamma-H2AX is a useful marker for DNA double strand breaks. Present study revealed that effects of anti-cancer drugs in glioma depend on cell lines, and cell cycle arrest and/or senescence play major roles in the effects. Progression of malignancy in glioma might be associated with inhibition of cell responses for DNA damages, since pathological specimens of glioma showed increasing positivity for H2AX as the grade of the glioma increased. In glioma, lots of nuclei with significant pleomorphism demonstrated both severe DNA damage and positivity for a cell-prolirerating marker. These results implies severe DNA damage induces nuclear pleomorphism and nuclear pleomorphism is not necessarily a direct evidence for malignancy.
|
