Gene therapy for neurodegenerative diseases using adeno-associated viral vectors that can cross the blood-brain barriers.

• Project/Area Number: 23590473
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: Jichi Medical University
• Principal Investigator: MURAMATSU Shinichi 自治医科大学, 医学部, 教授 (10239543)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 神経変性疾患 / 遺伝子治療

Research Abstract

We recently developed AAV vectors that can cross the blood-brain or meningeal-brain barriers. Using these AAV vectors, we have shown beneficial effects in mouse models of neurodegenerative diseases. The early intervention of miR-196a delivered by an AAV vector ameliorated the phenotypes in a mouse model of spinal and bulbar muscular atrophy. A single intracardiac administration of the vector carrying neprilysin gene in a mice model of Alzheimer disease reduced Abeta oligomers, with concurrent alleviation of abnormal learning and memory function. Gene delivery of the RNA-editing enzyme, adenosine deaminase, which acts on RNA 2 (ADAR2) in conditional ADAR2 knockout mice prevented progressive motor dysfunction. These AAV vectors may provide a novel platform for treating neurodegenerative diseases, especially where global transduction of a therapeutic gene into the brain is necessary.

Research Products

• [Journal Article] AADC deficiency: occurring in humans, modeled in rodents. (2013)
  • Author(s): Hwu WL, Lee NC, Chien YH, Muramatsu S, Ichinose H
  • Journal Title: Adv Pharmacol Volume: 68 Pages: 273-284
  • DOI: 10.1016/b978-0-12-411512-5.00013-0
  • Peer Reviewed
• [Journal Article] Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons (2013)
  • Author(s): Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S, Kwak S
  • Journal Title: EMBO Mol Med Volume: 5(11) Issue: 11 Pages: 1710-1719
  • DOI: 10.1002/emmm.201302935
  • Peer Reviewed
• [Journal Article] Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice. (2013)
  • Author(s): Iida A, Takino N, Miyauchi H, Shimazaki K, Muramatsu S
  • Journal Title: Bio Med Res Int Volume: 2013 Pages: 974819-974819
  • DOI: 10.1155/2013/974819
  • Peer Reviewed
• [Journal Article] Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice (2013)
  • Author(s): Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC.
  • Journal Title: Scientific Reports Volume: 3 Issue: 1 Pages: 1472-1472
  • DOI: 10.1038/srep01472
  • NAID: 120006985953
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency (2013)
  • Author(s): Lee, N.-C., Shieh, Y.-D., Chien, Y.-H., Tzen, K.-Y., Yu, I.-S., Chen, P.-W., Hu, M.-H., Hu, M., Muramatsu, S., Ichinose, H., et al.
  • Journal Title: Neurobiology of disease Volume: 52 Pages: 177-90
  • DOI: 10.1016/j.nbd.2012.12.005
  • Peer Reviewed
• [Journal Article] Intrastriatal gene delivery of GDNF persisitently attenuates methamphetamine self-administration and relapse in mice (2013)
  • Author(s): Yan Y, Miyamoto Y, Nitta A, Muramatsu S, Ozawa K, Yamada K, Nabeshima T
  • Journal Title: Int JNP Volume: 16 Issue: 7 Pages: 1559-1567
  • DOI: 10.1017/s1461145712001575
  • Peer Reviewed
• [Journal Article] Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Micevia a Non-Cell Autonomous Mechanism. (2012)
  • Author(s): H. Akiko Popiel
  • Journal Title: PLoS One Volume: 7 Issue: 11 Pages: e51069-e51069
  • DOI: 10.1371/journal.pone.0051069
  • Peer Reviewed
• [Journal Article] Careful clinical observation is essential for diagnosis of Huntington disease (2012)
  • Author(s): Nakamura K, Ota M, Kawata A, Isozaki E, Muramatsu S, Matsubara S
  • Journal Title: Arq Neuropsiquiatr Volume: 70(8) Issue: 8 Pages: 646-646
  • DOI: 10.1590/s0004-282x2012000800021
  • Peer Reviewed
• [Journal Article] Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells results in behavioral recovery in hemiparkinsonian mice (2012)
  • Author(s): Jin,D., Hashii,M., Higashida,H
  • Journal Title: Neurochem. Int Volume: 61 Issue: 6 Pages: 907-912
  • DOI: 10.1016/j.neuint.2011.12.021
  • NAID: 120004966609
  • Peer Reviewed
• [Journal Article] Gene therapy for aromatic L-amino acid decarboxylase deficiency. (2012)
  • Author(s): Hwu WL, Muramatsu S, Tseng SH, Tzen KY, Lee NC, Chien YH, Snyder RO, Brrne BJ, Tai CH, Wu RM
  • Journal Title: Sci Transl Med Volume: 16;4(134) Issue: 134 Pages: 134-161
  • DOI: 10.1126/scitranslmed.3003640
  • Peer Reviewed
• [Journal Article] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2 (2012)
  • Author(s): Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G
  • Journal Title: Nat Med Volume: 18 Issue: 7 Pages: 1136-1141
  • DOI: 10.1038/nm.2791
  • Peer Reviewed
• [Journal Article] Preclinical substantia nigra dysfunction in rapid eye movement sleep behaviour disorder (2012)
  • Author(s): Miyamoto M, Muramatsu S
  • Journal Title: Sleep Med Volume: 13(1) Issue: 1 Pages: 102-106
  • DOI: 10.1016/j.sleep.2011.03.024
  • Peer Reviewed
• [Journal Article] Careful clinical observation is essential for diagnosis of Huntington disease. (2012)
  • Author(s): Nakamura K, Ota M, Kawata A, Isozaki E, Muramatsu S, Matsubara S
  • Journal Title: Arq Neuropsiquiatr Volume: 70(8) Pages: 646-646
  • Peer Reviewed
• [Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection (2011)
  • Author(s): Tokuoka, H., Muramatsu, S., Sumi- Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D., and Ichinose, H.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Issue: 50 Pages: 43549-43558
  • DOI: 10.1074/jbc.m111.284729
  • Peer Reviewed
• [Journal Article] Subregional 6-[^<18>F]fluoro-ʟ-m-tyrosine uptake in the striatum in Parkinson's disease (2011)
  • Author(s): Asari S, Fujimoto K, Miyauchi A, Sato T, Nakano I, Muramatsu S
  • Journal Title: BMC Neurol Volume: 11 Issue: 1 Pages: 11-35
  • DOI: 10.1186/1471-2377-11-35
  • Peer Reviewed
• [Journal Article] Subregional 6-[18F]fluoro-L-m-tyrosine uptake in the striatum in Parkinson's disease. (2011)
  • Author(s): Asari S, Fujimoto K, Miyauchi A, Sato T, Nakano I and Muramatsu S
  • Journal Title: BMC Neurol Volume: - Pages: 11-35
  • URL: http://www.biomedcentral.com/1471-2377/11/35
  • Peer Reviewed
• [Presentation] idespread transduction of brain and spinal neurons following intra-thecal injection of AAV9/3 vectors in nonhuman primates and pigs (2014)
  • Author(s): Iida A, Takino N, Miyauchi H, Itoh M, Shibata H, Ono F and Muramatsu S
  • Organizer: International symposium"New Frontier of Molecular Neuropathology 2014"
  • Place of Presentation: Tokyo
  • Year and Date: 2014-03-17
• [Presentation] Parkinson病に対する遺伝子治療の現状と課題 (2014)
  • Author(s): 村松慎一
  • Organizer: 第53回日本定位・機能神経外科学会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2014-02-07
• [Presentation] 多系統萎縮症(NSA-P)のFMT-PET解析 (2013)
  • Author(s): 小野さやか,藤本健一,池口邦彦,村松慎一,中野今治
  • Organizer: Movement Disorder Society Japan第7回学術集会
  • Place of Presentation: 東京
  • Year and Date: 2013-10-11
• [Presentation] Global and effective gene delinery of neprilysin to the brain via intravascular administration of AAV vector in alzheimer's disease mice (2013)
  • Author(s): Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Muramatsu S and Saido TC
  • Organizer: The 19th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: Okayama
  • Year and Date: 2013-07-05
• [Presentation] Widespread neuronal transduction in the primate brain via intrathecal administration of adeno-associated virus vectors (2013)
  • Author(s): Iida A, Takino N, Miyauchi H, Shibata H, Ono F and Muramatsu S
  • Organizer: The 19th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: Okayama
  • Year and Date: 2013-07-04
• [Presentation] Different effects of shati/nat8l-overexpression on the responses to methamphetamine between in mice nucleus accumbens and dorsal striatum (2013)
  • Author(s): Nitta A, Ishikawa Y, Iegaki Y, Sumi K, Hurukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K and Miyamoto Y
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-22
• [Presentation] Distinct regulation mechanism of the dopamine content in the striatum from that in the midbrain (2013)
  • Author(s): Iwashita Y, Tokuoka H, Munezane H, Muramatsu S and Ichinose H
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-22
• [Presentation] Widespread transduction of neurons in the primate brain using intrathecal injection of AAV vectors (2013)
  • Author(s): Iida A, Takino N, Miyauchi H, Shibata H, Ono F and Muramatsu S
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-22
• [Presentation] Overexpression of shati/nat8l in the dorsal striatum affects emotional behaviors via dysfunction of serotonergic neuronal system in mice (2013)
  • Author(s): Miyamoto Y, Iegaki N, Sumi K, Ishikawa Y, Furuta T, Hibi Y, Muramatsu S, Nabeshima T, Uno K and Nitta A
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-21
• [Presentation] Gene therapy for Parkinson's disease : Advances and challenges (2013)
  • Author(s): Muramatsu S
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Kyoto
  • Year and Date: 2013-06-21
• [Presentation] パーキンソン病のAADC遺伝子治療:長期効果遺伝子発現の検証 (2013)
  • Author(s): 村松慎一
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2013-05-31
• [Presentation] Gene therapy clinical trial update for AADC (2013)
  • Author(s): Muramatsu S
  • Organizer: Cell and Gene Therapies for Inherited Metabolic Disease
  • Place of Presentation: London
  • Year and Date: 2013-04-17
• [Presentation] New frontiers in gene therapy of Parkinson Disease (2013)
  • Author(s): Muramatsu S
  • Organizer: Nuove frontiere nella terapia del Parkinson
  • Place of Presentation: Italy
  • Year and Date: 2013-02-22
• [Presentation] Parkinson病遺伝子治療の長期効果. Long-term outcomes of gene therapy for Parkinson disease (2013)
  • Author(s): 村松慎一
  • Organizer: 第52回日本定位・機能神経外科学会
  • Place of Presentation: 岡山
  • Year and Date: 2013-01-19
• [Presentation] AAVベクターによる神経疾患の遺伝子治療 (2012)
  • Author(s): 村松慎一
  • Organizer: 日本薬学界北陸支部特別講演会
  • Place of Presentation: 富山
  • Year and Date: 2012-11-12
• [Presentation] AADC欠損症の遺伝子治療 (2012)
  • Author(s): 村松慎一
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
  • Year and Date: 2012-10-26
• [Presentation] パーキンソン病の遺伝子治療におけるAADC遺伝子長期発現 (2012)
  • Author(s): 浅利さやか,中村優子,川上忠孝,池口邦彦,佐藤俊彦,村松慎一,福嶋敬宣,藤本健一,中野今治
  • Organizer: Movement Disorder Society Japan第6回学術集会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-13
• [Presentation] Gene therapy for Parkinson's disease : Progress and current challenges (2012)
  • Author(s): Muramatsu S
  • Organizer: 2012 Annual meeting of Genetic Epidemiology of Parkinson's Disease
  • Place of Presentation: Seoul
  • Year and Date: 2012-10-09
• [Presentation] The differences of the action of shati between the nucleus accumbens and dorsal striatum on the methamphetamine-induced addictive behaviors in mice (2012)
  • Author(s): Sumi K, Miyamoto Y, Ishikawa Y, Iegaki N, Muramatsu S, Hibi Y, Nabeshima T, Uno K and Nitta A
  • Organizer: The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe
  • Year and Date: 2012-10-02
• [Presentation] Parkinson病の遺伝子治療 (2012)
  • Author(s): 村松慎一
  • Organizer: 第11回日本再生医療学会総会パネルディスカッション
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-12
• [Presentation] パーキンソン病のすくみ足と青斑核のFMT-PET解析 (2012)
  • Author(s): 浅利さやか,村松慎一,藤本健一,齋藤順一,佐藤俊彦,中野今治
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-25
• [Presentation] Gene therapy for Parkinson's disease (2012)
  • Author(s): 村松慎一
  • Organizer: 第53回日本神経学会総会シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-05-24
• [Presentation] AADC Gene therapy for Parkinson's disease : results of 3-5 years of follow up (2012)
  • Author(s): Muramatsu S
  • Organizer: The 15th Annual Meeting of the American Society of Gene & Cell Therapy
  • Place of Presentation: Philadelphia
  • Year and Date: 2012-05-16
• [Presentation] Gene therapy : the state of the art (2011)
  • Author(s): Muramatsu S
  • Organizer: 6th International Expert Meeting on the Treatment of Parkinson's disease
  • Place of Presentation: Tokyo
  • Year and Date: 2011-10-30
• [Presentation] Gene therapy for Parkinson's disease : Four years follow-up (2011)
  • Author(s): Muramatsu S
  • Organizer: The 8th Nikko International Symposium 2011
  • Place of Presentation: Tochigi
  • Year and Date: 2011-10-21
• [Presentation] AADC gene therapy for Parkinson's disease : four years of follow-up (2011)
  • Author(s): Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
  • Organizer: The 34th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2011-09-17
• [Presentation] パーキンソン病の遺伝子治療 (2011)
  • Author(s): 村松慎一,浅利さやか,川上忠孝,池口邦彦,中野今治,水上浩明,卜部匡司,久米晃啓,小澤敬也,加藤正哉,渡辺英寿,佐藤俊彦
  • Organizer: 平成23年度第10回自治医科大学シンポジウム
  • Place of Presentation: 自治医科大学地域医療情報研修センター
  • Year and Date: 2011-09-02
• [Presentation] In vivo imaging in cell and gene therapy for Parkinson's disease (2011)
  • Author(s): Muramatsu S
  • Organizer: 17th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-07-17
• [Presentation] AADC gene therapy for Parkinson's disease : Four years of follow-up (2011)
  • Author(s): Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
  • Organizer: The 17th Annual Meeting of the Japan Society of Gene Therapy, Best Presentation
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-07-15
• [Presentation] A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease (2011)
  • Author(s): Muramatsu S
  • Organizer: The 17th Annual Meeting of the Japan Society of Gene Therapy, 2nd Takara Bio Award Lecture
  • Place of Presentation: Fukuoka
  • Year and Date: 2011-07-15
• [Presentation] Gene therapy for Parkinson's disease : Strategies for the local production of dopamine (2011)
  • Author(s): Muramatsu S
  • Organizer: The Federation of European Biochemical Societies 36th FEBS Congress
  • Place of Presentation: Torino
  • Year and Date: 2011-06-30
• [Presentation] PET assessment of the aromatic L-amino acid decarboxylase gene expression in a phase I gene therapy study for Parkinson's disease (2011)
  • Author(s): Asari S, Fujimoto K, Kato S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Watanabe E, Sato T, Ozawa K, Nakano I and Muramatsu S
  • Organizer: 15th International Congress of Parkinson's Disease and Movement Disorders
  • Place of Presentation: Toronto
  • Year and Date: 2011-06-09
• [Presentation] パーキンソン病(PD)の遺伝子治療におけるAADC遺伝子の長期発現 (2011)
  • Author(s): 浅利さやか,村松慎一,藤本健一,齋藤順一,佐藤俊彦,中野今治
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-19
• [Presentation] 血管内投与型AAVベクターによる乏突起膠細胞への遺伝子導入 (2011)
  • Author(s): 村松慎一,奈良優子,浅利さやか,宮内ひとみ,綾部啓子,滝野直美,中野今治,嶋崎久仁子
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] 凝集阻害分子の遺伝子治療によるポリグルタミン病モデルマウスに対する治療効果 (2011)
  • Author(s): ポピエルヘレナ明子,藤田寛美,山本和弘,武内敏秀,村松慎一,戸田達史,和田圭司,永井義隆
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-05-18
• [Presentation] 凝集阻害分子の遺伝子治療によるポリグルタミン病モデルマウスに対する治療効果. (2011)
  • Author(s): ポピエルヘレナ明子, 藤田寛美, 山本和弘, 武内敏秀, 村松慎一, 戸田達史, 和田圭司, 永井義隆
  • Organizer: 52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] 血管内投与型ＡＡＶベクターによる乏突起膠細胞への遺伝子導入. (2011)
  • Author(s): 村松慎一, 奈良優子, 浅利さやか, 宮内ひとみ, 綾部啓子, 滝野直美, 中野今治, 嶋崎久仁子
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] パーキンソン病（ＰＤ）の遺伝子治療におけるＡＡＤＣ遺伝子の長期発現. (2011)
  • Author(s): 浅利さやか, 村松慎一, 藤本健一, 齋藤順一, 佐藤俊彦, 中野今治
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] PET assessment of the aromatic L-amino acid decarboxylase gene expression in a phase I gene therapy study for Parkinson’s disease. (2011)
  • Author(s): Asari S, Fujimoto K, Kato S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Watanabe E, Sato T, Ozawa K, Nakano I and Muramatsu S
  • Organizer: 15th International Congress of Parkinson’s Disease and Movement Disorders
  • Place of Presentation: Toronto
• [Presentation] Gene therapy for Parkinson’s disease: Strategies for the local production of dopamine. (2011)
  • Author(s): Muramatsu S
  • Organizer: The Federation of European Biochemical Societies 36th FEBS Congress(招待講演)
  • Place of Presentation: Torino
• [Presentation] A phase Istudy of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease. (2011)
  • Author(s): Muramatsu S
  • Organizer: The 17th Annual Meeting of the Japan Society of Gene Therapy, 2nd Takara Bio Award Lecture
  • Place of Presentation: 福岡
• [Presentation] AADC gene therapy for Parkinson’s disease: Four years of follow-up. (2011)
  • Author(s): Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
  • Organizer: The 17th Annual Meeting of the Japan Society of Gene Therapy, Best Presentation
  • Place of Presentation: 福岡
• [Presentation] In vivo imaging in cell and gene therapy for Parkinson’s disease. (2011)
  • Author(s): Muramatsu S
  • Organizer: The 17th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: 福岡
• [Presentation] パーキンソン病の遺伝子治療. (2011)
  • Author(s): 村松慎一, 浅利さやか, 川上忠孝, 池口邦彦, 中野今治, 水上浩明, 卜部匡司, 久米晃啓, 小澤敬也, 加藤正哉, 渡辺英寿, 佐藤俊彦
  • Organizer: 平成２３年度 第10回自治医科大学シンポジウム
  • Place of Presentation: 自治医科大学 地域医療情報研修センター
• [Presentation] Gene therapy for Parkinson’s disease: Four years follow-up. (2011)
  • Author(s): Muramatsu S
  • Organizer: The 8th Nikko International Symposium 2011
  • Place of Presentation: 日光
• [Presentation] Gene therapy: the state of the art. (2011)
  • Author(s): Muramatsu S
  • Organizer: 6th International Expert Meeting on the Treatment of Parkinson’s disease
  • Place of Presentation: 東京
• [Presentation] Gene therapy clinical trial update for AADC.
  • Author(s): Muramatsu S
  • Organizer: Cell and Gene Therapies for Inherited Metabolic Disease
  • Place of Presentation: London
  • Invited
• [Presentation] パーキンソン病のAADC遺伝子治療：長期効果遺伝子発現の検証.
  • Author(s): 村松慎一
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Gene therapy for Parkinson’s disease: Advances and challenges.
  • Author(s): Muramatsu S
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 京都
• [Presentation] Overexpression of shati/nat8l in the dorsal striatum affects emotional behaviors via dysfunction of serotonergic neuronal system in mice.
  • Author(s): Miyamoto Y, Iegaki N, Sumi K, Ishikawa Y, Furuta T, Hibi Y, Muramatsu S, Nabeshima T, Uno K, Nitta A
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 京都
• [Presentation] Widespread transduction of neurons in the primate brain using intrathecal injection of AAV vectors.
  • Author(s): Iida A, Takino N, Miyauchi H, Shibata H, Ono F, Muramatsu S
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 京都
• [Presentation] Distinct regulation mechanism of the dopamine content in the striatum from that in the midbrain.
  • Author(s): Iwashita Y, Tokuoka H, Munezane H, Muramatsu S, Ichinose H
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 京都
• [Presentation] Different effects of shati/nat8l-overexpression on the responses to methamphetamine between in mice nucleus accumbens and dorsal striatum.
  • Author(s): Nitta A, Ishikawa Y, Iegaki Y, Sumi K, Hurukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K, Miyamoto Y
  • Organizer: The 36th Annual Meeting of Japan Neuroscience Society
  • Place of Presentation: 京都
• [Presentation] Widespread neuronal transduction in the primate brain via intrathecal administration of adeno-associated virus vectors.
  • Author(s): Iida A, Takino N, Miyauchi H, Shibata H, Ono F, Muramatsu S
  • Organizer: The 19th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: 岡山
• [Presentation] Global and effective gene delinery of neprilysin to the brain via intravascular administration of AAV vector in alzheimer’s disease mice.
  • Author(s): Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Muramatsu S, Saido TC
  • Organizer: The 19th Annual Meeting of the Japan Society of Gene Therapy
  • Place of Presentation: 岡山
• [Presentation] 多系統萎縮症(NSA-P)のFMT-PET解析.
  • Author(s): 小野さやか, 藤本健一, 池口邦彦, 村松慎一, 中野今治
  • Organizer: Movement Disorder Society Japan第7回学術集会
  • Place of Presentation: 東京
• [Presentation] Parkinson病に対する遺伝子治療の現状と課題.
  • Author(s): 村松慎一
  • Organizer: 第53回日本定位・機能神経外科学会 シンポジウム
  • Place of Presentation: 大阪
• [Presentation] AADC Gene therapy for Parkinson’s disease: results of 3-5 years of follow up.
  • Author(s): Muramatsu S
  • Organizer: The 15th Annual Meeting of the American Society of Gene & Cell Therapy
  • Place of Presentation: Philadelphia, USA
• [Presentation] Gene therapy for Parkinson’s disease.
  • Author(s): 村松慎一
  • Organizer: 第53回日本神経学会総会シンポジウム
  • Place of Presentation: 東京
• [Presentation] パーキンソン病のすくみ足と青斑核のＦＭＴ－ＰＥＴ解析.
  • Author(s): 浅利さやか, 村松慎一, 藤本健一, 齋藤順一, 佐藤俊彦, 中野今治
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Parkinson病の遺伝子治療.
  • Author(s): 村松慎一
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] The differences of the action of shati between the nucleus accumbens and dorsal striatum on the methamphetamine-induced addictive behaviors in mice.
  • Author(s): Sumi K, Miyamoto Y, Ishikawa Y, Iegaki N, Muramatsu S, Hibi Y, Nabeshima T, Uno K, Nitta A
  • Organizer: The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: 神戸
• [Presentation] Gene therapy for Parkinson’s disease: Progress and current challenges.
  • Author(s): Muramatsu S
  • Organizer: 2012 Annual meeting of Genetic Epidemiology of Parkinson’s Disease
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] パーキンソン病の遺伝子治療におけるＡＡＤＣ遺伝子長期発現.
  • Author(s): 浅利さやか, 中村優子, 川上忠孝, 池口邦彦, 佐藤俊彦, 村松慎一, 福嶋敬宣, 藤本健一, 中野今治
  • Organizer: Movement Disorder Society Japan第6回学術集会
  • Place of Presentation: 京都
• [Presentation] AADC欠損症の遺伝子治療.
  • Author(s): 村松慎一
  • Organizer: 日本人類遺伝学会 第57回大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] AAVベクターによる神経疾患の遺伝子治療.
  • Author(s): 村松慎一
  • Organizer: 日本薬学界北陸支部 特別講演会
  • Place of Presentation: 富山
  • Invited
• [Presentation] Parkinson病遺伝子治療の長期効果. Long-term outcomes of gene therapy for Parkinson disease.
  • Author(s): 村松慎一
  • Organizer: 第52回日本定位・機能神経外科学会
  • Place of Presentation: 岡山
• [Presentation] New frontiers in gene therapy of Parkinson Disease.
  • Author(s): Muramatsu S
  • Organizer: Nuove frontiere nella terapia del Parkinson
  • Place of Presentation: Bari, Italy
  • Invited
• [Book] Cell therapy for Parkinson's disease. In Human Fetal Tissue Transplantation (2013)
  • Author(s): Kondo Y, Okuno T, Asari S and Muramatsu S, (editors : Stubblefield P and Bhattacharya N)
  • Publisher: Springer-Verlag
• [Book] パーキンソン病の遺伝子治療・細胞移植,アクチュアル脳・神経疾患の臨床パーキンソン病と運動異常 (2013)
  • Author(s): 村松慎一, (辻省次壮編集,高橋良輔専門編集)
  • Publisher: 中山書店
• [Book] Cell therapy for Parkinson's disease. Clinical implications of fetal transplantation in Medicine. (2013)
  • Author(s): Kondo Y, Okuno T, Asari S, Muramatsu S
  • Total Pages: 11
  • Publisher: Springer-Verlag
• [Book] パーキンソン病の遺伝子治療・細胞移植, アクチュアル 脳・神経疾患の臨床 パーキンソン病と運動異常 (2013)
  • Author(s): 村松慎一
  • Total Pages: 8
  • Publisher: 中山書店
• [Book] Assessment of dopaminergic function in Parkinson's disease by SPECT/PET. Horizons in Neuroscience Research Volume 7 (2012)
  • Author(s): Muramatsu S, Asari S, (editors : Andres Costa and Eugenio Villalba)
  • Publisher: Nova Publishers
• [Book] Gene therapy for continuous dopamine production in Parkinson's disease. Dopamine : Functions, Regulation and Health Effects (2012)
  • Author(s): Muramatsu S, (editors : Endo Kudo and Yuriko Fujii)
  • Publisher: Nova Publishers
• [Book] パーキンソン病のAADC遺伝子治療, Parkinson's Disease 2012 (2012)
  • Author(s): 村松慎一, (山本光利編)
  • Publisher: アルタ出版
• [Book] 神経難病の治療のトピックス遺伝子治療・細胞治療,神経難病のリハビリテーション−症例を通して学ぶJournal of Clinical Rehabilitation別冊 (2012)
  • Author(s): 村松慎一, (江藤文夫,中馬孝容,葛原茂樹監修)
  • Publisher: 医歯薬出版株式会社
• [Book] 神経疾患②パーキンソン病,つまずき症例で学ぶ薬の処方徹底トレーニング (2011)
  • Author(s): 奈良優子,村松慎一, (藤村昭夫編)
  • Publisher: 羊土社
• [Book] その他の治療法,ガイドラインサポートハンドブックパーキンソン病 (2011)
  • Author(s): 村松慎一, (武田篤編)
  • Publisher: 医薬ジャーナル社
• [Book] 遺伝子治療は症状改善に有用か,パーキンソン病治療ガイドライン2011, パーキンソン病治療ガイドライン (2011)
  • Author(s): 日本神経学会監修, 「パーキンソン病治療ガイドライン」作成委員会編
  • Publisher: 医学書院
• [Book] 細胞移植は症状改善に有用か,パーキンソン病治療ガイドライン2011 (2011)
  • Author(s): 村松慎一, (日本神経学会監修,「パーキンソン病治療ガイドライン」作成委員会編)
  • Publisher: 医学書院