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Gene therapy for neurodegenerative diseases using adeno-associated viral vectors that can cross the blood-brain barriers.

Research Project

Project/Area Number 23590473
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental pathology
Research InstitutionJichi Medical University

Principal Investigator

MURAMATSU Shinichi  自治医科大学, 医学部, 教授 (10239543)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経変性疾患 / 遺伝子治療
Research Abstract

We recently developed AAV vectors that can cross the blood-brain or meningeal-brain barriers. Using these AAV vectors, we have shown beneficial effects in mouse models of neurodegenerative diseases. The early intervention of miR-196a delivered by an AAV vector ameliorated the phenotypes in a mouse model of spinal and bulbar muscular atrophy. A single intracardiac administration of the vector carrying neprilysin gene in a mice model of Alzheimer disease reduced Abeta oligomers, with concurrent alleviation of abnormal learning and memory function. Gene delivery of the RNA-editing enzyme, adenosine deaminase, which acts on RNA 2 (ADAR2) in conditional ADAR2 knockout mice prevented progressive motor dysfunction. These AAV vectors may provide a novel platform for treating neurodegenerative diseases, especially where global transduction of a therapeutic gene into the brain is necessary.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (96 results)

All 2014 2013 2012 2011 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 1 results) Presentation (68 results) (of which Invited: 5 results) Book (12 results)

  • [Journal Article] AADC deficiency: occurring in humans, modeled in rodents.2013

    • Author(s)
      Hwu WL, Lee NC, Chien YH, Muramatsu S, Ichinose H
    • Journal Title

      Adv Pharmacol

      Volume: 68 Pages: 273-284

    • DOI

      10.1016/b978-0-12-411512-5.00013-0

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rescue of amyotrophic lateral sclerosis phenotype in a mouse model by intravenous AAV9-ADAR2 delivery to motor neurons2013

    • Author(s)
      Yamashita T, Chai HL, Teramoto S, Tsuji S, Shimazaki K, Muramatsu S, Kwak S
    • Journal Title

      EMBO Mol Med

      Volume: 5(11) Issue: 11 Pages: 1710-1719

    • DOI

      10.1002/emmm.201302935

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Systemic delivery of tyrosine-mutant AAV vectors results in robust transduction of neurons in adult mice.2013

    • Author(s)
      Iida A, Takino N, Miyauchi H, Shimazaki K, Muramatsu S
    • Journal Title

      Bio Med Res Int

      Volume: 2013 Pages: 974819-974819

    • DOI

      10.1155/2013/974819

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice2013

    • Author(s)
      Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC.
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1472-1472

    • DOI

      10.1038/srep01472

    • NAID

      120006985953

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of the dopaminergic system in a murine model of aromatic L-amino acid decarboxylase deficiency2013

    • Author(s)
      Lee, N.-C., Shieh, Y.-D., Chien, Y.-H., Tzen, K.-Y., Yu, I.-S., Chen, P.-W., Hu, M.-H., Hu, M., Muramatsu, S., Ichinose, H., et al.
    • Journal Title

      Neurobiology of disease

      Volume: 52 Pages: 177-90

    • DOI

      10.1016/j.nbd.2012.12.005

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intrastriatal gene delivery of GDNF persisitently attenuates methamphetamine self-administration and relapse in mice2013

    • Author(s)
      Yan Y, Miyamoto Y, Nitta A, Muramatsu S, Ozawa K, Yamada K, Nabeshima T
    • Journal Title

      Int JNP

      Volume: 16 Issue: 7 Pages: 1559-1567

    • DOI

      10.1017/s1461145712001575

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hsp40 Gene Therapy Exerts Therapeutic Effects on Polyglutamine Disease Micevia a Non-Cell Autonomous Mechanism.2012

    • Author(s)
      H. Akiko Popiel
    • Journal Title

      PLoS One

      Volume: 7 Issue: 11 Pages: e51069-e51069

    • DOI

      10.1371/journal.pone.0051069

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Careful clinical observation is essential for diagnosis of Huntington disease2012

    • Author(s)
      Nakamura K, Ota M, Kawata A, Isozaki E, Muramatsu S, Matsubara S
    • Journal Title

      Arq Neuropsiquiatr

      Volume: 70(8) Issue: 8 Pages: 646-646

    • DOI

      10.1590/s0004-282x2012000800021

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells results in behavioral recovery in hemiparkinsonian mice2012

    • Author(s)
      Jin,D., Hashii,M., Higashida,H
    • Journal Title

      Neurochem. Int

      Volume: 61 Issue: 6 Pages: 907-912

    • DOI

      10.1016/j.neuint.2011.12.021

    • NAID

      120004966609

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gene therapy for aromatic L-amino acid decarboxylase deficiency.2012

    • Author(s)
      Hwu WL, Muramatsu S, Tseng SH, Tzen KY, Lee NC, Chien YH, Snyder RO, Brrne BJ, Tai CH, Wu RM
    • Journal Title

      Sci Transl Med

      Volume: 16;4(134) Issue: 134 Pages: 134-161

    • DOI

      10.1126/scitranslmed.3003640

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF22012

    • Author(s)
      Miyazaki Y, Adachi H, Katsuno M, Minamiyama M, Jiang YM, Huang Z, Doi H, Matsumoto S, Kondo N, Iida M, Tohnai G, Tanaka F, Muramatsu S, Sobue G
    • Journal Title

      Nat Med

      Volume: 18 Issue: 7 Pages: 1136-1141

    • DOI

      10.1038/nm.2791

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preclinical substantia nigra dysfunction in rapid eye movement sleep behaviour disorder2012

    • Author(s)
      Miyamoto M, Muramatsu S
    • Journal Title

      Sleep Med

      Volume: 13(1) Issue: 1 Pages: 102-106

    • DOI

      10.1016/j.sleep.2011.03.024

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Careful clinical observation is essential for diagnosis of Huntington disease.2012

    • Author(s)
      Nakamura K, Ota M, Kawata A, Isozaki E, Muramatsu S, Matsubara S
    • Journal Title

      Arq Neuropsiquiatr

      Volume: 70(8) Pages: 646-646

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection2011

    • Author(s)
      Tokuoka, H., Muramatsu, S., Sumi- Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D., and Ichinose, H.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Issue: 50 Pages: 43549-43558

    • DOI

      10.1074/jbc.m111.284729

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Subregional 6-[^<18>F]fluoro-ʟ-m-tyrosine uptake in the striatum in Parkinson's disease2011

    • Author(s)
      Asari S, Fujimoto K, Miyauchi A, Sato T, Nakano I, Muramatsu S
    • Journal Title

      BMC Neurol

      Volume: 11 Issue: 1 Pages: 11-35

    • DOI

      10.1186/1471-2377-11-35

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Subregional 6-[18F]fluoro-L-m-tyrosine uptake in the striatum in Parkinson's disease.2011

    • Author(s)
      Asari S, Fujimoto K, Miyauchi A, Sato T, Nakano I and Muramatsu S
    • Journal Title

      BMC Neurol

      Volume: - Pages: 11-35

    • URL

      http://www.biomedcentral.com/1471-2377/11/35

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] idespread transduction of brain and spinal neurons following intra-thecal injection of AAV9/3 vectors in nonhuman primates and pigs2014

    • Author(s)
      Iida A, Takino N, Miyauchi H, Itoh M, Shibata H, Ono F and Muramatsu S
    • Organizer
      International symposium"New Frontier of Molecular Neuropathology 2014"
    • Place of Presentation
      Tokyo
    • Year and Date
      2014-03-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Parkinson病に対する遺伝子治療の現状と課題2014

    • Author(s)
      村松慎一
    • Organizer
      第53回日本定位・機能神経外科学会シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2014-02-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 多系統萎縮症(NSA-P)のFMT-PET解析2013

    • Author(s)
      小野さやか,藤本健一,池口邦彦,村松慎一,中野今治
    • Organizer
      Movement Disorder Society Japan第7回学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Global and effective gene delinery of neprilysin to the brain via intravascular administration of AAV vector in alzheimer's disease mice2013

    • Author(s)
      Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Muramatsu S and Saido TC
    • Organizer
      The 19th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      Okayama
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Widespread neuronal transduction in the primate brain via intrathecal administration of adeno-associated virus vectors2013

    • Author(s)
      Iida A, Takino N, Miyauchi H, Shibata H, Ono F and Muramatsu S
    • Organizer
      The 19th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      Okayama
    • Year and Date
      2013-07-04
    • Related Report
      2013 Final Research Report
  • [Presentation] Different effects of shati/nat8l-overexpression on the responses to methamphetamine between in mice nucleus accumbens and dorsal striatum2013

    • Author(s)
      Nitta A, Ishikawa Y, Iegaki Y, Sumi K, Hurukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K and Miyamoto Y
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Distinct regulation mechanism of the dopamine content in the striatum from that in the midbrain2013

    • Author(s)
      Iwashita Y, Tokuoka H, Munezane H, Muramatsu S and Ichinose H
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Widespread transduction of neurons in the primate brain using intrathecal injection of AAV vectors2013

    • Author(s)
      Iida A, Takino N, Miyauchi H, Shibata H, Ono F and Muramatsu S
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Overexpression of shati/nat8l in the dorsal striatum affects emotional behaviors via dysfunction of serotonergic neuronal system in mice2013

    • Author(s)
      Miyamoto Y, Iegaki N, Sumi K, Ishikawa Y, Furuta T, Hibi Y, Muramatsu S, Nabeshima T, Uno K and Nitta A
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy for Parkinson's disease : Advances and challenges2013

    • Author(s)
      Muramatsu S
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Kyoto
    • Year and Date
      2013-06-21
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病のAADC遺伝子治療:長期効果遺伝子発現の検証2013

    • Author(s)
      村松慎一
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy clinical trial update for AADC2013

    • Author(s)
      Muramatsu S
    • Organizer
      Cell and Gene Therapies for Inherited Metabolic Disease
    • Place of Presentation
      London
    • Year and Date
      2013-04-17
    • Related Report
      2013 Final Research Report
  • [Presentation] New frontiers in gene therapy of Parkinson Disease2013

    • Author(s)
      Muramatsu S
    • Organizer
      Nuove frontiere nella terapia del Parkinson
    • Place of Presentation
      Italy
    • Year and Date
      2013-02-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Parkinson病遺伝子治療の長期効果. Long-term outcomes of gene therapy for Parkinson disease2013

    • Author(s)
      村松慎一
    • Organizer
      第52回日本定位・機能神経外科学会
    • Place of Presentation
      岡山
    • Year and Date
      2013-01-19
    • Related Report
      2013 Final Research Report
  • [Presentation] AAVベクターによる神経疾患の遺伝子治療2012

    • Author(s)
      村松慎一
    • Organizer
      日本薬学界北陸支部特別講演会
    • Place of Presentation
      富山
    • Year and Date
      2012-11-12
    • Related Report
      2013 Final Research Report
  • [Presentation] AADC欠損症の遺伝子治療2012

    • Author(s)
      村松慎一
    • Organizer
      日本人類遺伝学会第57回大会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病の遺伝子治療におけるAADC遺伝子長期発現2012

    • Author(s)
      浅利さやか,中村優子,川上忠孝,池口邦彦,佐藤俊彦,村松慎一,福嶋敬宣,藤本健一,中野今治
    • Organizer
      Movement Disorder Society Japan第6回学術集会
    • Place of Presentation
      京都
    • Year and Date
      2012-10-13
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy for Parkinson's disease : Progress and current challenges2012

    • Author(s)
      Muramatsu S
    • Organizer
      2012 Annual meeting of Genetic Epidemiology of Parkinson's Disease
    • Place of Presentation
      Seoul
    • Year and Date
      2012-10-09
    • Related Report
      2013 Final Research Report
  • [Presentation] The differences of the action of shati between the nucleus accumbens and dorsal striatum on the methamphetamine-induced addictive behaviors in mice2012

    • Author(s)
      Sumi K, Miyamoto Y, Ishikawa Y, Iegaki N, Muramatsu S, Hibi Y, Nabeshima T, Uno K and Nitta A
    • Organizer
      The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Kobe
    • Year and Date
      2012-10-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Parkinson病の遺伝子治療2012

    • Author(s)
      村松慎一
    • Organizer
      第11回日本再生医療学会総会パネルディスカッション
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-12
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病のすくみ足と青斑核のFMT-PET解析2012

    • Author(s)
      浅利さやか,村松慎一,藤本健一,齋藤順一,佐藤俊彦,中野今治
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy for Parkinson's disease2012

    • Author(s)
      村松慎一
    • Organizer
      第53回日本神経学会総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2012-05-24
    • Related Report
      2013 Final Research Report
  • [Presentation] AADC Gene therapy for Parkinson's disease : results of 3-5 years of follow up2012

    • Author(s)
      Muramatsu S
    • Organizer
      The 15th Annual Meeting of the American Society of Gene & Cell Therapy
    • Place of Presentation
      Philadelphia
    • Year and Date
      2012-05-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy : the state of the art2011

    • Author(s)
      Muramatsu S
    • Organizer
      6th International Expert Meeting on the Treatment of Parkinson's disease
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-10-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy for Parkinson's disease : Four years follow-up2011

    • Author(s)
      Muramatsu S
    • Organizer
      The 8th Nikko International Symposium 2011
    • Place of Presentation
      Tochigi
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] AADC gene therapy for Parkinson's disease : four years of follow-up2011

    • Author(s)
      Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
    • Organizer
      The 34th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      Yokohama
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病の遺伝子治療2011

    • Author(s)
      村松慎一,浅利さやか,川上忠孝,池口邦彦,中野今治,水上浩明,卜部匡司,久米晃啓,小澤敬也,加藤正哉,渡辺英寿,佐藤俊彦
    • Organizer
      平成23年度第10回自治医科大学シンポジウム
    • Place of Presentation
      自治医科大学地域医療情報研修センター
    • Year and Date
      2011-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] In vivo imaging in cell and gene therapy for Parkinson's disease2011

    • Author(s)
      Muramatsu S
    • Organizer
      17th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-07-17
    • Related Report
      2013 Final Research Report
  • [Presentation] AADC gene therapy for Parkinson's disease : Four years of follow-up2011

    • Author(s)
      Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy, Best Presentation
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease2011

    • Author(s)
      Muramatsu S
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy, 2nd Takara Bio Award Lecture
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-07-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene therapy for Parkinson's disease : Strategies for the local production of dopamine2011

    • Author(s)
      Muramatsu S
    • Organizer
      The Federation of European Biochemical Societies 36th FEBS Congress
    • Place of Presentation
      Torino
    • Year and Date
      2011-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] PET assessment of the aromatic L-amino acid decarboxylase gene expression in a phase I gene therapy study for Parkinson's disease2011

    • Author(s)
      Asari S, Fujimoto K, Kato S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Watanabe E, Sato T, Ozawa K, Nakano I and Muramatsu S
    • Organizer
      15th International Congress of Parkinson's Disease and Movement Disorders
    • Place of Presentation
      Toronto
    • Year and Date
      2011-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病(PD)の遺伝子治療におけるAADC遺伝子の長期発現2011

    • Author(s)
      浅利さやか,村松慎一,藤本健一,齋藤順一,佐藤俊彦,中野今治
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 血管内投与型AAVベクターによる乏突起膠細胞への遺伝子導入2011

    • Author(s)
      村松慎一,奈良優子,浅利さやか,宮内ひとみ,綾部啓子,滝野直美,中野今治,嶋崎久仁子
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 凝集阻害分子の遺伝子治療によるポリグルタミン病モデルマウスに対する治療効果2011

    • Author(s)
      ポピエルヘレナ明子,藤田寛美,山本和弘,武内敏秀,村松慎一,戸田達史,和田圭司,永井義隆
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 凝集阻害分子の遺伝子治療によるポリグルタミン病モデルマウスに対する治療効果.2011

    • Author(s)
      ポピエルヘレナ明子, 藤田寛美, 山本和弘, 武内敏秀, 村松慎一, 戸田達史, 和田圭司, 永井義隆
    • Organizer
      52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 血管内投与型AAVベクターによる乏突起膠細胞への遺伝子導入.2011

    • Author(s)
      村松慎一, 奈良優子, 浅利さやか, 宮内ひとみ, 綾部啓子, 滝野直美, 中野今治, 嶋崎久仁子
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] パーキンソン病(PD)の遺伝子治療におけるAADC遺伝子の長期発現.2011

    • Author(s)
      浅利さやか, 村松慎一, 藤本健一, 齋藤順一, 佐藤俊彦, 中野今治
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] PET assessment of the aromatic L-amino acid decarboxylase gene expression in a phase I gene therapy study for Parkinson’s disease.2011

    • Author(s)
      Asari S, Fujimoto K, Kato S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Watanabe E, Sato T, Ozawa K, Nakano I and Muramatsu S
    • Organizer
      15th International Congress of Parkinson’s Disease and Movement Disorders
    • Place of Presentation
      Toronto
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene therapy for Parkinson’s disease: Strategies for the local production of dopamine.2011

    • Author(s)
      Muramatsu S
    • Organizer
      The Federation of European Biochemical Societies 36th FEBS Congress(招待講演)
    • Place of Presentation
      Torino
    • Related Report
      2011 Research-status Report
  • [Presentation] A phase Istudy of aromatic L-amino acid decarboxylase gene therapy for Parkinson’s disease.2011

    • Author(s)
      Muramatsu S
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy, 2nd Takara Bio Award Lecture
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] AADC gene therapy for Parkinson’s disease: Four years of follow-up.2011

    • Author(s)
      Muramatsu S, Fujimoto K, Kato S, Asari S, Mizukami H, Ikeguchi K, Kawakami T, Urabe M, Kume A, Sato T, Watanabe E, Ozawa K and Nakano I
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy, Best Presentation
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] In vivo imaging in cell and gene therapy for Parkinson’s disease.2011

    • Author(s)
      Muramatsu S
    • Organizer
      The 17th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] パーキンソン病の遺伝子治療.2011

    • Author(s)
      村松慎一, 浅利さやか, 川上忠孝, 池口邦彦, 中野今治, 水上浩明, 卜部匡司, 久米晃啓, 小澤敬也, 加藤正哉, 渡辺英寿, 佐藤俊彦
    • Organizer
      平成23年度 第10回自治医科大学シンポジウム
    • Place of Presentation
      自治医科大学 地域医療情報研修センター
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene therapy for Parkinson’s disease: Four years follow-up.2011

    • Author(s)
      Muramatsu S
    • Organizer
      The 8th Nikko International Symposium 2011
    • Place of Presentation
      日光
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene therapy: the state of the art.2011

    • Author(s)
      Muramatsu S
    • Organizer
      6th International Expert Meeting on the Treatment of Parkinson’s disease
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Gene therapy clinical trial update for AADC.

    • Author(s)
      Muramatsu S
    • Organizer
      Cell and Gene Therapies for Inherited Metabolic Disease
    • Place of Presentation
      London
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] パーキンソン病のAADC遺伝子治療:長期効果遺伝子発現の検証.

    • Author(s)
      村松慎一
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Gene therapy for Parkinson’s disease: Advances and challenges.

    • Author(s)
      Muramatsu S
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Overexpression of shati/nat8l in the dorsal striatum affects emotional behaviors via dysfunction of serotonergic neuronal system in mice.

    • Author(s)
      Miyamoto Y, Iegaki N, Sumi K, Ishikawa Y, Furuta T, Hibi Y, Muramatsu S, Nabeshima T, Uno K, Nitta A
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Widespread transduction of neurons in the primate brain using intrathecal injection of AAV vectors.

    • Author(s)
      Iida A, Takino N, Miyauchi H, Shibata H, Ono F, Muramatsu S
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Distinct regulation mechanism of the dopamine content in the striatum from that in the midbrain.

    • Author(s)
      Iwashita Y, Tokuoka H, Munezane H, Muramatsu S, Ichinose H
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Different effects of shati/nat8l-overexpression on the responses to methamphetamine between in mice nucleus accumbens and dorsal striatum.

    • Author(s)
      Nitta A, Ishikawa Y, Iegaki Y, Sumi K, Hurukawa-Hibi Y, Muramatsu S, Nabeshima T, Uno K, Miyamoto Y
    • Organizer
      The 36th Annual Meeting of Japan Neuroscience Society
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Widespread neuronal transduction in the primate brain via intrathecal administration of adeno-associated virus vectors.

    • Author(s)
      Iida A, Takino N, Miyauchi H, Shibata H, Ono F, Muramatsu S
    • Organizer
      The 19th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Global and effective gene delinery of neprilysin to the brain via intravascular administration of AAV vector in alzheimer’s disease mice.

    • Author(s)
      Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Muramatsu S, Saido TC
    • Organizer
      The 19th Annual Meeting of the Japan Society of Gene Therapy
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 多系統萎縮症(NSA-P)のFMT-PET解析.

    • Author(s)
      小野さやか, 藤本健一, 池口邦彦, 村松慎一, 中野今治
    • Organizer
      Movement Disorder Society Japan第7回学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Parkinson病に対する遺伝子治療の現状と課題.

    • Author(s)
      村松慎一
    • Organizer
      第53回日本定位・機能神経外科学会 シンポジウム
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] AADC Gene therapy for Parkinson’s disease: results of 3-5 years of follow up.

    • Author(s)
      Muramatsu S
    • Organizer
      The 15th Annual Meeting of the American Society of Gene & Cell Therapy
    • Place of Presentation
      Philadelphia, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Gene therapy for Parkinson’s disease.

    • Author(s)
      村松慎一
    • Organizer
      第53回日本神経学会総会シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] パーキンソン病のすくみ足と青斑核のFMT-PET解析.

    • Author(s)
      浅利さやか, 村松慎一, 藤本健一, 齋藤順一, 佐藤俊彦, 中野今治
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Parkinson病の遺伝子治療.

    • Author(s)
      村松慎一
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] The differences of the action of shati between the nucleus accumbens and dorsal striatum on the methamphetamine-induced addictive behaviors in mice.

    • Author(s)
      Sumi K, Miyamoto Y, Ishikawa Y, Iegaki N, Muramatsu S, Hibi Y, Nabeshima T, Uno K, Nitta A
    • Organizer
      The 11th Biennial Meeting of the Asian-Pacific Society for Neurochemistry/55th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Gene therapy for Parkinson’s disease: Progress and current challenges.

    • Author(s)
      Muramatsu S
    • Organizer
      2012 Annual meeting of Genetic Epidemiology of Parkinson’s Disease
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] パーキンソン病の遺伝子治療におけるAADC遺伝子長期発現.

    • Author(s)
      浅利さやか, 中村優子, 川上忠孝, 池口邦彦, 佐藤俊彦, 村松慎一, 福嶋敬宣, 藤本健一, 中野今治
    • Organizer
      Movement Disorder Society Japan第6回学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] AADC欠損症の遺伝子治療.

    • Author(s)
      村松慎一
    • Organizer
      日本人類遺伝学会 第57回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] AAVベクターによる神経疾患の遺伝子治療.

    • Author(s)
      村松慎一
    • Organizer
      日本薬学界北陸支部 特別講演会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Parkinson病遺伝子治療の長期効果. Long-term outcomes of gene therapy for Parkinson disease.

    • Author(s)
      村松慎一
    • Organizer
      第52回日本定位・機能神経外科学会
    • Place of Presentation
      岡山
    • Related Report
      2012 Research-status Report
  • [Presentation] New frontiers in gene therapy of Parkinson Disease.

    • Author(s)
      Muramatsu S
    • Organizer
      Nuove frontiere nella terapia del Parkinson
    • Place of Presentation
      Bari, Italy
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] Cell therapy for Parkinson's disease. In Human Fetal Tissue Transplantation2013

    • Author(s)
      Kondo Y, Okuno T, Asari S and Muramatsu S, (editors : Stubblefield P and Bhattacharya N)
    • Publisher
      Springer-Verlag
    • Related Report
      2013 Final Research Report
  • [Book] パーキンソン病の遺伝子治療・細胞移植,アクチュアル脳・神経疾患の臨床パーキンソン病と運動異常2013

    • Author(s)
      村松慎一, (辻省次壮編集,高橋良輔専門編集)
    • Publisher
      中山書店
    • Related Report
      2013 Final Research Report
  • [Book] Cell therapy for Parkinson's disease. Clinical implications of fetal transplantation in Medicine.2013

    • Author(s)
      Kondo Y, Okuno T, Asari S, Muramatsu S
    • Total Pages
      11
    • Publisher
      Springer-Verlag
    • Related Report
      2013 Annual Research Report
  • [Book] パーキンソン病の遺伝子治療・細胞移植, アクチュアル 脳・神経疾患の臨床 パーキンソン病と運動異常2013

    • Author(s)
      村松慎一
    • Total Pages
      8
    • Publisher
      中山書店
    • Related Report
      2013 Annual Research Report
  • [Book] Assessment of dopaminergic function in Parkinson's disease by SPECT/PET. Horizons in Neuroscience Research Volume 72012

    • Author(s)
      Muramatsu S, Asari S, (editors : Andres Costa and Eugenio Villalba)
    • Publisher
      Nova Publishers
    • Related Report
      2013 Final Research Report
  • [Book] Gene therapy for continuous dopamine production in Parkinson's disease. Dopamine : Functions, Regulation and Health Effects2012

    • Author(s)
      Muramatsu S, (editors : Endo Kudo and Yuriko Fujii)
    • Publisher
      Nova Publishers
    • Related Report
      2013 Final Research Report
  • [Book] パーキンソン病のAADC遺伝子治療, Parkinson's Disease 20122012

    • Author(s)
      村松慎一, (山本光利編)
    • Publisher
      アルタ出版
    • Related Report
      2013 Final Research Report
  • [Book] 神経難病の治療のトピックス遺伝子治療・細胞治療,神経難病のリハビリテーション−症例を通して学ぶJournal of Clinical Rehabilitation別冊2012

    • Author(s)
      村松慎一, (江藤文夫,中馬孝容,葛原茂樹監修)
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2013 Final Research Report
  • [Book] 神経疾患②パーキンソン病,つまずき症例で学ぶ薬の処方徹底トレーニング2011

    • Author(s)
      奈良優子,村松慎一, (藤村昭夫編)
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] その他の治療法,ガイドラインサポートハンドブックパーキンソン病2011

    • Author(s)
      村松慎一, (武田篤編)
    • Publisher
      医薬ジャーナル社
    • Related Report
      2013 Final Research Report
  • [Book] 遺伝子治療は症状改善に有用か,パーキンソン病治療ガイドライン2011, パーキンソン病治療ガイドライン2011

    • Author(s)
      日本神経学会監修, 「パーキンソン病治療ガイドライン」作成委員会編
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] 細胞移植は症状改善に有用か,パーキンソン病治療ガイドライン20112011

    • Author(s)
      村松慎一, (日本神経学会監修,「パーキンソン病治療ガイドライン」作成委員会編)
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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