Development of a novel therapeutic for AIDS using humanized mouse model and improvement of HAART

• Project/Area Number: 23590481
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental pathology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: OKUMA Kazu 国立感染症研究所, 血液・安全性研究部, 室長 (80315085)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Yuetsu 琉球大学, 免疫学講座, 教授 (30163588)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヒト免疫不全ウイルス１型 / エイズ / 新規治療薬 / ヒト化マウス / 感染実験動物モデル / 感染モデル

Research Abstract

In order to improve the standard therapy for AIDS/human immunodeficiency virus (HIV) infection, HAART, recombinant vesicular stomatitis viruses (rVSVs) expressing HIV-1 receptors and/or OX40L were generated as candidates for novel drugs. In vitro and in immunodeficient mice transplanted with hematopoietic stem cells from human cord blood (humanized mice) and then infected by HIV-1, the rVSVs could inhibit HIV-1 infection, indicating that they have a therapeutic potential for AIDS/HIV-1 infection.

Research Products

• [Presentation] Recombinant vesicular stomatitis viruses targeting HIV-1-infected cells control HIV-1 infection in a humanized mouse model (2012)
  • Author(s): Okuma K, Watanabe S, Tanaka Y, Yamamoto N, Rose JK, Hamaguchi I
  • Organizer: American Society for Virology, 31st Annual Meeting
  • Place of Presentation: Madison, WI, U.S.A
• [Presentation] Recombinant vesicular stomatitis viruses targeting HIV-1-infected cells control HIV-1 infection in a humanized mouse model (2012)
  • Author(s): Okuma K
  • Organizer: American Society for Virology, 31st Annual Meeting
  • Place of Presentation: Madison, WI, U.S.A.
• [Presentation] Development of a recombinant vesicular stomatitis virus that targets CCR5-tropic HIV-1-infected cells and inhibits HIV-1 infection (2011)
  • Author(s): Okuma K, Tanaka R, Hamaguchi I, Rose JK, Tanaka Y
  • Organizer: American Society for Virology, 30th Annual Meeting
  • Place of Presentation: Minneapolis, MN, U.S.A
• [Presentation] ヒト化NOGマウスを用いたR5 HIV-1標的組換えVSVの薬効性評価 (2011)
  • Author(s): 大隈和、深川耕次、高馬卓也、渡辺哲、田中勇悦、山本直樹、浜口功
  • Organizer: 第25回日本エイズ学会学術集会
  • Place of Presentation: 東京
• [Presentation] Development of a recombinant vesicular stomatitis virus that targets CCR5-tropic HIV-1-infected cells and inhibits HIV-1 infection (2011)
  • Author(s): Okuma K
  • Organizer: American Society for Virology, 30th Annual Meeting
  • Place of Presentation: Minneapolis, MN, U.S.A.
• [Remarks] 国立感染症研究所ホームページ
  • URL: http://www.nih.go.jp/niid/ja/from-safety/578-safety3.html
• [Remarks] 国立感染症研究所ホームページ
  • URL: http://www.nih.go.jp/niid/ja/from-safety/578-safety3.html