Molecular mechanism of miR-143/145 down-regulation in cancer and disease
| Project/Area Number |
23590483
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center (2012-2013)
Gifu International Institute of Biotechnology (2011) |
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Principal Investigator |
IIO Akio 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, リサーチレジデント (80344349)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAO Yukihiro 岐阜大学院, 連合創薬, 教授 (00222505)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | microRNA / 癌 / プロモーター / DDX6 / P-body |
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| Research Abstract |
In this study, we found that NCR143/145 promoter was feed-back regulated by SRF/ELK1 and its regulatory mechanisms were disrupted in cancers. Furthermore, we showed that DDX6 and AGO2 promoted the nuclear export and degradation of NCR143/145 RNA through decapping followed by miR-143/145 down-regulation.
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Report
(4 results)
Research Products
(3 results)
