| Project/Area Number |
23590493
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NIIKURA Mamoru 杏林大学, 医学部, 助教 (30407019)
INOUE Shin-ichi 杏林大学, 医学部, 助教 (20466030)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | マラリア / 妊娠 / 免疫抑制 / 病態重症化 / 肝障害 / 一酸化窒素 / 肝傷害 / PAM / マウスモデル / 病態解析 / 遺伝子改変原虫 |
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| Research Abstract |
In this study, we established a mouse model of pathological features of pregnant women living in malaria-endemic regions and investigated the pathogenesis of malaria during pregnancy using the mouse model. Pregnant mice immunized by infection of nonlethal Plasmodium berghei (Pb) XAT were more susceptible to lethal Pb NK65 challenged infection than non-pregnant mice and showed high levels of parasitemia and poor pregnancy outcome associated with placental pathology in late phase of pregnancy. Notably, the pregnant immunized mice infected with Pb NK65 developed liver injury in late phase of pregnancy. Higher levels of IFN-gamma and NO were observed in plasma from pregnant immunized mice infected with Pb NK65 compared with those in non-pregnant immunized mice infected with Pb NK65. These findings suggest that development of liver injury and placental pathology in pregnant immunized mice infected with Pb NK65 are associated with enhanced production of pro-inflammatory cytokines.
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