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Host immune responses and parasite delived substances associated with the establishment of chronic infection

Research Project

Project/Area Number 23590497
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Parasitology (including Sanitary zoology)
Research InstitutionJikei University School of Medicine

Principal Investigator

ISHIWATA Kenji  東京慈恵会医科大学, 医学部, 准教授 (00241307)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords消化管寄生虫 / 慢性感染 / 宿主免疫応答 / 寄生虫成分 / 樹状細胞 / 粘膜免疫 / 蠕虫 / 腸管免疫 / 感染 / 寄生虫 / Nippostrongylus / Heligmosomoides / マウス / 腸管寄生虫感染
Research Abstract

Although human body has an immune system which recognizes and rejects foreign pathogens, intestinal parasites establish in the gut for a long time; i.e. chronic infections. The mechanism of the infection was examined by mice model. Results suggested that the mouse immune response was suppressed at the very early phase of the infection. Parasite derived substances, such as excretory-secretory products, were thought to cause the suppression, however, the analysis is still in process.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (20 results)

All 2014 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (14 results) (of which Invited: 1 results) Book (1 results) Remarks (4 results)

  • [Journal Article] Role of mast cells and basophils in IgE responses and in allergic airway hyperresponsiveness2012

    • Author(s)
      Sawaguchi-M, Tanaka-S, Nakatani-Y, Harada-Y, Mukai-K, Matsunaga-Y, Ishiwata-K, Oboki-K, Kambayashi-T, Watanabe-N, Karasuyama-H, Nakae-S, Inose-H, Kubo-M
    • Journal Title

      Journal of Immunology

      Volume: 188 Pages: 1809-1818

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 消化管寄生線虫の急性感染と慢性感染の混合感染による相互作用2014

    • Author(s)
      石渡賢治
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      松山市
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Antigen-presenting cell responses of mesenteric lymph nodes in mice infected with a gastrointestinal nematode, Nippostrongylus brasiliensis2014

    • Author(s)
      Ishiwata-K
    • Organizer
      13th International Symposium on Dendritic Cells
    • Place of Presentation
      Loire Valley, France
    • Related Report
      2013 Final Research Report
  • [Presentation] 消化管寄生線虫の急性感染と慢性感染の混合感染による相互作用2014

    • Author(s)
      石渡賢治
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛県松山市(愛媛大学城北キャンパス)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antigen-presenting cell responses of mesenteric lymph nodes in mice infected with a gastrointestinal nematode, Nippostrongylus brasiliensis2014

    • Author(s)
      Ishiwata-K
    • Organizer
      13Th International Symposium on Dendritic Cells
    • Place of Presentation
      Loire Valley, France
    • Related Report
      2013 Annual Research Report
  • [Presentation] Antigen-presenting cell responses in mesenteric lymph nodes of mice infected with gastrointestinal nematodes2013

    • Author(s)
      Ishiwata-K
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      千葉市
    • Year and Date
      2013-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管寄生線虫感染における所属リンパ節樹状細胞の応答2013

    • Author(s)
      石渡賢治
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京都
    • Year and Date
      2013-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Antigen presenting cell responses in mesenteric lymph nodes of mice infected with gastrointestinal nematodes2013

    • Author(s)
      Ishiwata-K
    • Organizer
      日本免疫学会総会・学術集会
    • Place of Presentation
      千葉市(幕張メッセ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 腸管寄生線虫感染における所属リンパ節樹状細胞の応答2013

    • Author(s)
      石渡賢治
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
  • [Presentation] 寄生虫感染における腸管免疫の進歩2012

    • Author(s)
      石渡賢治
    • Organizer
      第19回日本免疫毒性学会学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2012-09-16
    • Related Report
      2013 Final Research Report
  • [Presentation] Nippostrongylus brasiliensis感染マウスにおける腸間膜リンパ節の免疫応答2012

    • Author(s)
      石渡賢治
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      西宮市
    • Year and Date
      2012-03-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 寄生虫感染における腸管免疫の進歩2012

    • Author(s)
      石渡賢治
    • Organizer
      第19回日本免疫毒性学会学術大会
    • Place of Presentation
      東京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 腸管内寄生蠕虫感染における宿主免疫応答2011

    • Author(s)
      石渡賢治
    • Organizer
      日本大学生物資源科学部動物医科学研究センターセミナー
    • Place of Presentation
      藤沢市
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Nippostrongylus brasiliensis感染マウスにおける腸間膜リンパ節の免疫応答

    • Author(s)
      石渡賢治
    • Organizer
      日本寄生虫学会
    • Place of Presentation
      兵庫医科大学 西宮キャンパス
    • Related Report
      2011 Research-status Report
  • [Presentation] 腸管内寄生蠕虫感染における宿主免疫応答

    • Author(s)
      石渡賢治
    • Organizer
      日本大学生物資源科学部 動物医科学研究センターセミナー(招待講演)
    • Place of Presentation
      日本大学生物資源科学部
    • Related Report
      2011 Research-status Report
  • [Book] 臨床免疫・アレルギー科 サイトカインのすべて(完全改訂版)2012

    • Author(s)
      矢田純一・宮坂信之 編集
    • Total Pages
      861
    • Publisher
      科学評論社
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.jikei-tropmed.jp/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 東京慈恵会医科大学 熱帯医学講座

    • URL

      http://www.jikei-tropmed.jp/index.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東京慈恵会医科大学 熱帯医学講座

    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://jikei-tropmed.jp/

    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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