Development of predictive model for future prevalence of antimalarial-resistant gene using microsatellite polymorphism
| Project/Area Number |
23590498
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | Juntendo University (2012-2014)
Tokyo Women's Medical University (2011) |
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Principal Investigator |
Mita Toshihiro 順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | マラリア / 薬剤耐性 / 耐性遺伝子 / 予測モデル / シミュレーション / 数理モデル / 熱帯熱マラリア / 数理解析 / 耐性遺伝子頻度予測 |
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| Outline of Final Research Achievements |
Malaria is one of the three major infectious disease including tuberculosis and HIV/AIDS. The biggest barrier for the global achievement of malaria control is emergence and spread of drug resistant malaria. This study successfully created a model that can estimate a level of selective advantage in drug-resistant parasite by one-point sampling and by using this estimate, predict the trajectory of drug resistant allele prevalence. This model will be able to be applicable to various malaria endemic regions and provide future estimation of drug-resistance without frequent sampling.
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Report
(5 results)
Research Products
(38 results)
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[Journal Article] Generation of Rodent Malaria Parasites with a High Mutation Rate by destructing Proofreading activity of DNA Polymerase2014
Author(s)
Honma H, Hirai M, Nakamura S, Hakimi H, Kawazu S, Palacpac N, Hisaeda H, Matsuoka H, Kawai S, Endo H, Yssunaga T, Ohashi J, Mita T, Horii T, Furusawa M, Tanabe K.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt2012
Author(s)
Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, Sattabongkot J, Nakamura M, Sakurai M, Kobayashi J, Kaneko A, Endo H, Hombhanje F, Tsuboi T, Mita T
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Journal Title
Malaria Journal
Volume: 11
Issue: 1
Pages: 92-92
DOI
NAID
Related Report
Peer Reviewed
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