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Contribution of bacterial sialylation in the development of postinfectious autoimmune peripheral neuropathy

Research Project

Project/Area Number 23590509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionYamaguchi University

Principal Investigator

KOGA Michiaki  山口大学, 医学部附属病院, 講師 (60383014)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsカンピロバクター / ギラン・バレー症候群 / シアル酸 / ガングリオシド / リポオリゴ糖
Research Abstract

Guillain-Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy and most GBS patients have infectious symptoms 1-3 weeks before neurological onset. Campylobacter jejuni, a leading cause of acute enteritis in developed countries, is the most frequent antecedent infectious agent in GBS. Gangliosides (glycosphingolipids with sialic acids) have been identified as a target molecule of GBS after C. jejuni enteritis. In this study, previous these findings lead to examine whether high sialic acid modification ability of C. jejuni is a risk factor for development of GBS. Disappointedly, there was no difference in sialic acid content between the GBS and enteritis (as control) isolates. This was the same when only the strains with ganglioside epitopes or GBS-related LOS biosynthesis locus were analyzed. These results suggest that the quality of the sialylation is more important than the quantity for the development of this syndrome.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (65 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (44 results) (of which Peer Reviewed: 23 results) Presentation (16 results) (of which Invited: 4 results) Book (5 results)

  • [Journal Article] Sera from multifocal motor neuropathy patients disrupt the blood-nerve barrier.2014

    • Author(s)
      Shimizu F, Omoto M, Sano Y, Tasaki A, Matsui N, Miyashiro A, Koga M, Kaji R, Kanda T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Pages: 526-537

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autocrine MMP-2/9 secretion increases the BBB permeability in neuromyelitis optica.2014

    • Author(s)
      Tasaki A, Shimizu F, Sano Y, Fujisawa M, Takahashi T, Haruki H, Abe M, Koga M, Kanda T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 85 Pages: 419-430

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sera from remitting and secondary progressive multiple sclerosis patients disrupt the blood-brain barrier.2014

    • Author(s)
      Shimizu F, Tasaki A, Sano Y, Ju M, Nishihara H, Oishi M, Koga M, Kawai M, Kanda T.
    • Journal Title

      PLoS One

      Volume: 9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bickerstaff型脳幹脳炎2014

    • Author(s)
      古賀道明
    • Journal Title

      日本臨床 別冊 神経症候群(第2版)

      Volume: 27 Pages: 709-712

    • Related Report
      2013 Annual Research Report
  • [Journal Article] サルコイドニューロパチー2014

    • Author(s)
      古賀道明
    • Journal Title

      Brain Nerve

      Volume: -

    • NAID

      40020173792

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 末梢神経の構造と機能2014

    • Author(s)
      大石真莉子 古賀道明 神田 隆
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 254-257

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Another CNS phenotype of anti-GQ1b antibody syndrome2013

    • Author(s)
      Koga M
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 84 Pages: 1185-1185

    • Related Report
      2013 Final Research Report
  • [Journal Article] Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: An in vitro study2013

    • Author(s)
      Saito K, Shimizu F, Koga M, Sano Y, Abe M, Tasaki A, Maeda T, Haruki H, Suzuki S, Kusunoki S, Mizusawa H Kanda T.
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 84 Pages: 756-765

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The demyelination neurophysiological criteria can be misleading in Campylobacter jejuni-related Guillain-Barré syndrome.2013

    • Author(s)
      Kokubun N, Shahrizaila N, Koga M, Hirata K, Yuki N.
    • Journal Title

      Clin Neurophysiol

      Volume: 124 Pages: 1671-1679

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement2013

    • Author(s)
      Haruki H, Sano Y, Shimizu F, Omoto M, Tasaki A, Oishi M, Koga M, Saito T, Takahashi T, Nakada T, Kanda T.
    • Journal Title

      J Neurol Sci

      Volume: 331 Pages: 136-144

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自律神経ニューロパチーの治療2013

    • Author(s)
      古賀道明
    • Journal Title

      神経治療

      Volume: 30 Pages: 11-15

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] 急性汎自律神経異常症とニコチン性アセチルコリン受容体抗体2013

    • Author(s)
      古賀道明
    • Journal Title

      Brain Nerve

      Volume: 65 Pages: 425-432

    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Journal Article] ビッカースタッフ型脳幹脳炎の疫学と診断・治療2013

    • Author(s)
      古賀道明
    • Journal Title

      日本アフェレシス学会雑誌

      Volume: 71 Pages: 898-903

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ギラン・バレー症候群に対するアフェレシス療法2013

    • Author(s)
      古賀道明
    • Journal Title

      日本アフェレシス学会雑誌

      Volume: 32 Pages: 181-184

    • NAID

      110009661551

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ビッカースタッフ型脳幹脳炎の全国疫学調査から分かったこと:病態機序の多様性2013

    • Author(s)
      古賀道明
    • Journal Title

      臨床神経

      Volume: 53 Pages: 1322-1324

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 神経疾患の新しい治療:現場での必須の知識と今後の展望:脳炎、プリオン病2013

    • Author(s)
      古賀道明 神田 隆
    • Journal Title

      日内会誌

      Volume: 102 Pages: 1958-1964

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Reply from the Author: 外転眼に注視方向性の粗大な水平性眼振を伴い,中枢神経障害の関与が示唆された急性外眼筋麻痺2013

    • Author(s)
      生田尚美 多田由紀子 古賀道明
    • Journal Title

      臨床神経

      Volume: 53 Pages: 381-381

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MSとNMOの疫学の最新情報2013

    • Author(s)
      大石真莉子 古賀道明 神田 隆
    • Journal Title

      Pharma Medica

      Volume: 31 Pages: 13-16

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Another CNS phenotype of anti-GQ1b antibody syndrome.2013

    • Author(s)
      Koga M
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: An in vitro study2013

    • Author(s)
      Saito K
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The demyelination neurophysiological criteria can be misleading in Campylobacter jejuni-related Guillain-Barré syndrome2013

    • Author(s)
      Kokubun N
    • Journal Title

      Clin Neurophysiol

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経疾患の新しい治療:現場での必須の知識と今後の展望:脳炎、プリオン病2013

    • Author(s)
      古賀道明
    • Journal Title

      日内会誌

      Volume: -

    • Related Report
      2012 Research-status Report
  • [Journal Article] ビッカースタッフ型脳幹脳炎の疫学と診断・治療2013

    • Author(s)
      古賀道明
    • Journal Title

      日本臨床

      Volume: 71 Pages: 898-903

    • Related Report
      2012 Research-status Report
  • [Journal Article] GQ1b-seronegative Fisher syndrome : Clinical features and new serological markers2012

    • Author(s)
      Koga M, Gilbert M, Takahashi M, Li J, Hirata K, Kanda T, Yuki N
    • Journal Title

      J Neurol

      Volume: 252 Pages: 1366-1374

    • NAID

      10030408249

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis : epidemiological and clinical characteristics2012

    • Author(s)
      Koga M, Kusunoki S, Kaida K, Uehara R, Nakamura Y, Kohriyama T, Kanda T
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Pages: 1210-1215

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of patients in Japan with Bickerstaff brainstem encephalitis: epidemiological and clinical characteristics2012

    • Author(s)
      Koga M
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 83 Pages: 1210-1215

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autosomal dominant tauopathy with parkinsonism and central hypoventilation2012

    • Author(s)
      Omoto M
    • Journal Title

      Neurology

      Volume: 78 Pages: 762-764

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Neuropathy in chronic graft-versus-host disease caused by Donor T cells2012

    • Author(s)
      Haruki H
    • Journal Title

      Muscle Nerve

      Volume: 46 Pages: 610-611

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] トロサ・ハント症候群2012

    • Author(s)
      古賀道明
    • Journal Title

      内科

      Volume: 109(増大号) Pages: 947-948

    • Related Report
      2012 Research-status Report
  • [Journal Article] Autonomic neuropathy2012

    • Author(s)
      古賀道明
    • Journal Title

      Brain Medical

      Volume: 24 Pages: 7-12

    • Related Report
      2012 Research-status Report
  • [Journal Article] 自律神経ニューロパチー2012

    • Author(s)
      古賀道明
    • Journal Title

      最新医学別冊新しい診断・治療のABC 75/神経6末梢神経障害

      Volume: - Pages: 144-151

    • Related Report
      2012 Research-status Report
  • [Journal Article] 外転眼に注視方向性の粗大な水平性眼振を伴い,中枢神経障害の関与が示唆された急性外眼筋麻痺2012

    • Author(s)
      生田尚美
    • Journal Title

      臨床神経

      Volume: 52 Pages: 433-435

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 二相性の運動麻痺をきたしたワクチン関連麻痺性ポリオ(vaccine-associated paralytic poliomyelitis, VAPP)の38歳男性例2012

    • Author(s)
      大石真莉子
    • Journal Title

      臨床神経

      Volume: 52 Pages: 744-749

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] しびれの臨床:神経免疫疾患(免疫介在性ニューロパチー、多発性硬化症)2012

    • Author(s)
      神田 隆
    • Journal Title

      日本医師会雑誌

      Volume: 141 Pages: 106-108

    • Related Report
      2012 Research-status Report
  • [Journal Article] GQ1b-seronegative Fisher syndrome: Clinical features and new serological markers2012

    • Author(s)
      Koga M
    • Journal Title

      Journal of Neurology

      Volume: -

    • NAID

      10030408249

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Sera from neuromyelitis optica patients disrupt the blood brain barrier2012

    • Author(s)
      Shimizu F
    • Journal Title

      Journal of Neurology, Neurosurgery, and Psychiatry

      Volume: 83 Pages: 288-297

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 外転眼に注視方向性の粗大な水平性眼振を伴い,中枢神経障害の関与が示唆された急性外眼筋麻痺2012

    • Author(s)
      生田尚美
    • Journal Title

      臨床神経学

      Volume: -

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 足の感覚異常2012

    • Author(s)
      古賀道明
    • Journal Title

      Monthly Book Derma.

      Volume: 188 Pages: 71-76

    • Related Report
      2011 Research-status Report
  • [Journal Article] Bilateral abducens palsy in a case of cytomegalovirus-associated Guillain-Barre syndrome2011

    • Author(s)
      Kishi M
    • Journal Title

      Neurological Sciences

      Volume: 32 Pages: 1219-1222

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 感覚障害を主徴とし,免疫グロブリン静注療法により速やかに改善した遠位型慢性炎症性脱髄性多発ニューロパチーの46歳男性例2011

    • Author(s)
      竹下幸男
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 478-481

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IgG4関連自己免疫性膵炎による膵腫大を呈したPOEMS症候群2011

    • Author(s)
      西原秀昭
    • Journal Title

      臨床神経学

      Volume: 51 Pages: 417-421

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] GQ1b-seronegative Fisher症候群:臨床像と新たな診断マーカー2011

    • Author(s)
      古賀道明
    • Journal Title

      末梢神経

      Volume: 22 Pages: 159-160

    • NAID

      10030408249

    • Related Report
      2011 Research-status Report
  • [Journal Article] 免疫性末梢神経障害の抗体療法2011

    • Author(s)
      古賀道明
    • Journal Title

      神経治療学

      Volume: 28 Pages: 139-143

    • Related Report
      2011 Research-status Report
  • [Journal Article] 自律神経性ニューロパチーの疾患の拡がり、疾患概念とその異同2011

    • Author(s)
      古賀道明
    • Journal Title

      自律神経

      Volume: 48 Pages: 94-95

    • NAID

      10029303829

    • Related Report
      2011 Research-status Report
  • [Presentation] ギラン・バレー症候群におけるIgM型抗ガングリオシド抗体の意義2013

    • Author(s)
      古賀道明、高橋正樹、神田隆
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関(海峡メッセ下関)
    • Related Report
      2013 Final Research Report
  • [Presentation] Bickerstaff型脳幹脳炎の全国疫学調査から分かったこと:病態機序の多様性2013

    • Author(s)
      古賀道明
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ギラン・バレー症候群におけるアフェレシス2013

    • Author(s)
      古賀道明
    • Organizer
      第34回日本アフェレシス学会学術大会
    • Place of Presentation
      長野(軽井沢プリンスホテル)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] フィッシャー症候群は免疫療法の適応となりえるか?:初診時の診断からみた検討2013

    • Author(s)
      古賀道明
    • Organizer
      第54回日本神経学会学術大会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ギラン・バレー症候群におけるIgM型抗ガングリオシド抗体の意義2013

    • Author(s)
      古賀道明
    • Organizer
      第25回日本神経免疫学会学術集会
    • Place of Presentation
      下関(海峡メッセ)
    • Related Report
      2013 Annual Research Report
  • [Presentation] GQ1b-seronegative Fisher syndrome : serological study2011

    • Author(s)
      Koga M, Kanda T, Yuki N
    • Organizer
      Biennial Meeting of the Peripheral Nerve Society
    • Place of Presentation
      Potomac, Maryland, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] ギラン・バレー症候群発症におけるカンピロバクター・シアル化の意義2011

    • Author(s)
      古賀道明、高橋正樹、結城伸泰、神田隆
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Related Report
      2013 Final Research Report
  • [Presentation] GQ1b-seronegative Fisher syndrome: serological study2011

    • Author(s)
      Koga M
    • Organizer
      Biennial Meeting of the Peripheral Nerve Society
    • Place of Presentation
      Potomac, Maryland, USA (Bolger Center)
    • Related Report
      2011 Research-status Report
  • [Presentation] ギラン・バレー症候群発症におけるカンピロバクター・シアル化の意義2011

    • Author(s)
      古賀道明
    • Organizer
      第52回日本神経学会学術大会
    • Place of Presentation
      愛知県(名古屋国際会議場)
    • Related Report
      2011 Research-status Report
  • [Presentation] GQ1b-seronegative Fisher症候群:臨床像と新たな診断マーカー2011

    • Author(s)
      古賀道明
    • Organizer
      第22回日本末梢神経学会学術集会
    • Place of Presentation
      沖縄(沖縄コンベンションセンター)
    • Related Report
      2011 Research-status Report
  • [Presentation] ビッカースタッフ型脳幹脳炎における感染症の関与:ギラン・バレー症候群との差異2011

    • Author(s)
      古賀道明
    • Organizer
      第23回日本神経免疫学会学術集会
    • Place of Presentation
      東京(京王プラザホテル)
    • Related Report
      2011 Research-status Report
  • [Presentation] ギラン・バレー症候群や類縁疾患におけるプラズマフェレシス

    • Author(s)
      古賀道明
    • Organizer
      第33回日本アフェレシス学会学術大会
    • Place of Presentation
      長崎県(ハウステンボス)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Bickerstaff型脳幹脳炎の全国疫学調査:脳幹脳炎の中での位置づけと臨床像・治療の現状

    • Author(s)
      古賀道明
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京都(東京国際フォーラム)
    • Related Report
      2012 Research-status Report
  • [Presentation] Fisher症候群は免疫療法の適応となりえるか?:初診時の診断からみた検討

    • Author(s)
      古賀道明
    • Organizer
      第23回日本末梢神経学会学術集会
    • Place of Presentation
      福岡県(九州大学医学部百年講堂)
    • Related Report
      2012 Research-status Report
  • [Presentation] Bickerstaff型脳幹脳炎の全国疫学調査:脳幹脳炎の中での位置づけと臨床像・治療の現状

    • Author(s)
      古賀道明
    • Organizer
      第24回日本神経免疫学会学術集会
    • Place of Presentation
      長野県(軽井沢プリンスホテル)
    • Related Report
      2012 Research-status Report
  • [Presentation] 免疫性ニューロパチーの最新知見:治療(ランチョンセミナー)

    • Author(s)
      古賀道明
    • Organizer
      第24回日本神経免疫学会学術集会
    • Place of Presentation
      長野県(軽井沢プリンスホテル)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Book] 今日の治療指針2015年版, ギラン・バレー症候群2015

    • Author(s)
      古賀道明, (山田徹、他編集)
    • Publisher
      医学書院(印刷中)
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療指針 2015年版2014

    • Author(s)
      古賀道明
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の神経疾患治療指針 第2版2013

    • Author(s)
      古賀道明
    • Total Pages
      10
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report 2012 Research-status Report
  • [Book] 免疫疾患イラストレイテッド2013

    • Author(s)
      古賀道明
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の治療指針 2012年版:私はこう治療している 20122012

    • Author(s)
      古賀道明
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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