Contribution of bacterial sialylation in the development of postinfectious autoimmune peripheral neuropathy
| Project/Area Number |
23590509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KOGA Michiaki 山口大学, 医学部附属病院, 講師 (60383014)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | カンピロバクター / ギラン・バレー症候群 / シアル酸 / ガングリオシド / リポオリゴ糖 |
|---|
| Research Abstract |
Guillain-Barre syndrome (GBS) is an autoimmune-mediated peripheral neuropathy and most GBS patients have infectious symptoms 1-3 weeks before neurological onset. Campylobacter jejuni, a leading cause of acute enteritis in developed countries, is the most frequent antecedent infectious agent in GBS. Gangliosides (glycosphingolipids with sialic acids) have been identified as a target molecule of GBS after C. jejuni enteritis. In this study, previous these findings lead to examine whether high sialic acid modification ability of C. jejuni is a risk factor for development of GBS. Disappointedly, there was no difference in sialic acid content between the GBS and enteritis (as control) isolates. This was the same when only the strains with ganglioside epitopes or GBS-related LOS biosynthesis locus were analyzed. These results suggest that the quality of the sialylation is more important than the quantity for the development of this syndrome.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Blood-brain barrier destruction determines Fisher/Bickerstaff clinical phenotypes: An in vitro study2013
Author(s)
Saito K, Shimizu F, Koga M, Sano Y, Abe M, Tasaki A, Maeda T, Haruki H, Suzuki S, Kusunoki S, Mizusawa H Kanda T.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 84
Pages: 756-765
Related Report
Peer Reviewed
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[Journal Article] NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement2013
Author(s)
Haruki H, Sano Y, Shimizu F, Omoto M, Tasaki A, Oishi M, Koga M, Saito T, Takahashi T, Nakada T, Kanda T.
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Journal Title
J Neurol Sci
Volume: 331
Pages: 136-144
Related Report
Peer Reviewed
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