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Development of new bacterial control system

Research Project

Project/Area Number 23590512
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionThe University of Tokushima

Principal Investigator

MASEDA Hideaki  徳島大学, ソシオテクノサイエンス研究部, 准教授 (10372343)

Co-Investigator(Kenkyū-buntansha) OMASA Takeshi  徳島大学, 大学院ソシオテクノサイエンス研究部, 教授 (00252586)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords多剤耐性菌 / efflux pump / Pseudomonas / 薬剤耐性 / 微生物制御 / 抗生物質 / 薬剤耐性菌 / 遺伝子改変 / 多剤耐性
Outline of Final Research Achievements

An infection control has been carried out mainly on sterilization up to now. But as using many bactericide and antibiotics, many kinds of resistant bacteria appear and it is big social problem. It is so difficult to restrict use of all antibiotics and if the control method out of which a multi-drug resistant strain isn't taken is established, the contribution to the human race is immeasurable. So I tried to make the process clear and by restrain that process, embarking on an effort to establish new control method out of which resistant bacteria doesn't take. As a result, I identified the genes and the proteins that are indispensable to tolerization of bacteria and showed some big knowledge for establishment of new control system of resistant bacteria.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (12 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Two routes of MexS-MexT-mediated regulation of MexEF-OprN and MexAB-OprM efflux pump expression in Pseudomonas aeruginosa2013

    • Author(s)
      Maki Uwate et al
    • Journal Title

      Microbiology and Immunolagy

      Volume: - Issue: 4 Pages: 263-272

    • DOI

      10.1111/1348-0421.12032

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological properties of thiazolyl-acetic acid derivatives as possible antimicrobial agents2013

    • Author(s)
      Akihiro Shirai et al
    • Journal Title

      Biocontrol Science

      Volume: 18

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Action of Reactive Oxygen Species in the Antifungal Mechanism of Gemini-pyridinium Salts Against Yeast2012

    • Author(s)
      Akihiro Shirai et al
    • Journal Title

      Biocontrol Science

      Volume: 17 Issue: 2 Pages: 77-82

    • DOI

      10.4265/bio.17.77

    • NAID

      10030826450

    • ISSN
      1342-4815, 1884-0205
    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functionalization of MexT Enhances MexEF-OprN Expression to Overcome Its Repression by MvaT in Pseudomonas aeruginosa2012

    • Author(s)
      Uwate Maki et al
    • Journal Title

      Journal of Bioindustrial Science

      Volume: 1 Pages: 10-14

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid and high efficiency transformation of Sphingomonas and Sphingopyxis by electroporation using frozen cell suspensions2012

    • Author(s)
      Hideaki Maseda et al
    • Journal Title

      Journal of Bioindustrial Science

      Volume: 1 Pages: 1-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] How microcystin-degrading bacteria express microcystin degradation activity2012

    • Author(s)
      Li Jieming et al
    • Journal Title

      Bioresource Technology

      Volume: 106 Pages: 27-35

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of MlrB Involved in Degradation of the Cyanobacterial Toxin Microcystin LR2011

    • Author(s)
      Kobayashi Hiroaki
    • Journal Title

      Resouces Envionment Life

      Volume: 1 Pages: 186-190

    • Related Report
      2011 Research-status Report
  • [Journal Article] MexT-mediated Regulation of MexEF-OprN Multidrug Efflux Pump via Nod Box in Pseudomonas aeruginosa2011

    • Author(s)
      Uwate Maki
    • Journal Title

      Resouces Envionment Life

      Volume: 1 Pages: 191-198

    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌多剤耐性株におけるmexS-mexT遺伝子による耐性制御2012

    • Author(s)
      間世田 英明 他
    • Organizer
      第41回薬剤耐性菌研究会
    • Place of Presentation
      望川館(岐阜県)
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑膿菌多剤耐性株の耐性機構の解析とその性状2012

    • Author(s)
      間世田 英明 他
    • Organizer
      日本生物工学会 西日本支部 第2回講演会
    • Place of Presentation
      岡山大学(岡山県)
    • Related Report
      2012 Research-status Report
  • [Presentation] MexS cancels the MexT-dependent repression of MexAB-OprM efflux pump in Pseudomonas aeruginosa2011

    • Author(s)
      Uwate Maki
    • Organizer
      International Union of Microbiology Societies
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] Expression of Microcystin degradation activity in microcystin-degrading bacterium2011

    • Author(s)
      Shimizu Kazuya
    • Organizer
      International Union of Microbiology Societies
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌ゲノムでの薬剤耐性調節遺伝子mexTの出現機構の解析

    • Author(s)
      上手 麻希, 横田 優子, 黒山 亜美, 市瀬 裕樹, 白井 昭博, 中江 太治, 間世田 英明
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] MexEF-OprN薬剤排出ポンプの発現と緑膿菌野生株での役割

    • Author(s)
      市瀬 裕樹, 上手 麻希, 黒山 亜美, 横田 優子, 白井 昭博, 中江 太治, 間世田 英明
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 多剤耐性緑膿菌NfxC変異株におけるイミペネム耐性機構の解析

    • Author(s)
      黒山 亜美, 市瀬 裕樹, 上手 麻希, 横田 優子, 白井 昭博, 中江 太治, 間世田 英明
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 特定の塩基配列の欠失による耐性関連遺伝子出現機構の解析

    • Author(s)
      横田 優子, 上手 麻希, 市瀬 裕樹, 黒山 亜美, 白井 昭博, 中江 太治, 間世田 英明
    • Organizer
      日本細菌学会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2013 Research-status Report
  • [Presentation] 緑膿菌MexEF-OprN薬剤排出ポンプの一過的な発現調節機構

    • Author(s)
      市瀬 裕樹, 上手 麻希, 大政 健史, 間世田 英明
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学生田キャンパス(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] 緑膿菌ゲノムでの薬剤耐性調節遺伝子mexTの出現

    • Author(s)
      上手 麻希, 横田 優子, 大政 健史, 間世田 英明
    • Organizer
      日本農芸化学会
    • Place of Presentation
      明治大学生田キャンパス(神奈川県)
    • Related Report
      2013 Research-status Report
  • [Presentation] Analysis of transient expression of MexEF-OprN efflux pump in Pseudomnas aeruginosa

    • Author(s)
      Ichise Yu-ki, Uwate Maki, Nakae Taiji and Hideaki Maseda
    • Organizer
      he 12th Japan-Koria International Symposium on Microbiology 2014
    • Place of Presentation
      タワーホール船堀(TOKYO)
    • Related Report
      2013 Research-status Report
  • [Presentation] Expression of antibiotic resistance genes by specific nucleotide deletion in Pseudomonas aeruginosa

    • Author(s)
      Uwate Maki, Ichise Yu-ki, Nakae Taiji and Hideaki Maseda
    • Organizer
      The 12th Japan-Koria International Symposium on Microbiology 2014
    • Place of Presentation
      タワーホール船堀(TOKYO)
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] 発現カセット2014

    • Inventor(s)
      間世田英明、上手麻希
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-016814
    • Filing Date
      2014-02-05
    • Related Report
      2013 Research-status Report
  • [Patent(Industrial Property Rights)] スクリーニング方法2014

    • Inventor(s)
      間世田英明、上手麻希
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-016816
    • Filing Date
      2014-02-05
    • Related Report
      2013 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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