| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this proposal, I have aimed to identify the ligands of NLRP3 and NLRC4 proteins, which are regulators of the inflammatory caspase, caspase-1. Although I could not accomplish the final goal within the period, on the process of analysing the mechanism of the NLRP3 activation, I have gotten important progress to approach the signaling pathway that NLRP3 mediates; namely, (1) the NLRP3 activation coincides with the increase of intracellular ceramide; (2) chloride ions play an important role in the NLRP3 activation; (3) the extract from Zanthoxylum bungeanum inhibits the extracellular transport of the mature IL-1beta peptide.
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