| Project/Area Number |
23590516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Okayama University (2012-2013)
Kitasato University (2011) |
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Principal Investigator |
MATSUSHITA Osamu 岡山大学, 医歯(薬)学総合研究科, 教授 (00209537)
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| Co-Investigator(Kenkyū-buntansha) |
ADACHI Eijiro 北里大学, 医学(系)研究科(研究院), 教授 (30110430)
INOUE Jo 京都大学, 医学(系)研究科(研究院), 助教 (00433714)
MORI Nozomu 香川大学, 医学部, 教授 (90124883)
UCHIDA Kentaro 北里大学, 医学部, 助教 (50547578)
|
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| Co-Investigator(Renkei-kenkyūsha) |
MIMA Takehiko 岡山大学, 医歯(薬)学総合研究科, 助教 (80596437)
MIYASHITA Takenori 香川大学, 医学部, 助教 (60363214)
|
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
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| Keywords | 細菌毒素 / コラーゲン結合ドメイン / 細胞外マトリックス / 膠原線維 / アンカーリング / 骨新生 / 再生医療 / 技術移転 / アンカーリンク / PKDドメイン |
|---|
| Research Abstract |
Flesh-eating bacteria produce collagenases, enzymes to degrade tissue collagen fibrils. The enzyme possesses a collagen-binding domain(s). Although its molecular size is small, the domain forms sandwich-like structure to bind to untwisted region of triple-helical collagen molecule. Meanwhile, human growth factor accelerates cell growth. Various growth factors were fused with the domain to anchor them on tissue collagen fibrils, demineralized bone matrix, or collagen sheet/particles. Using these novel materials, osteogenesis or angiogenesis was successfully induced.
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