| Project/Area Number |
23590518
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shinichi 杏林大学, 医学部, 教授 (10137953)
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| Co-Investigator(Renkei-kenkyūsha) |
OSAKI Takako 杏林大学, 医学部, 准教授 (90255406)
HANAWA Tomoko 杏林大学, 医学部, 講師 (80255405)
YONEZAWA Hideo 杏林大学, 医学部, 講師 (60453528)
KURATA Satoshi 杏林大学, 医学部, 学内講師 (00383670)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | ヘリコバクター・ピロリ / 胃粘膜 / フローラ / T-RFLP / 胃炎 / 胃癌 |
|---|
| Research Abstract |
Correlation between Helicobacter pylori and gastric microbiota was examined for the patients with chronic gastritis and gastric cancer. It was shown that streptococci were dominant in the patients with gastritis regardless of H. pylori infection and that Atopobacterium, Enterococcus and Lactobacillus were detected only in the H. pylori positive gastritis patients. Gastric microbiota of the patient with gastric cancer was similar to that of H. pylori-negative gastritis patients. By meta-genome analysis, it was shown that Neisseriaceae, Burkholderiaceae and Enterobacteiaceae, Pseudomonadaceae were dominant Proteobacteria for the H. pylori positive and negative patients with gastritis, respectively. These results suggest that H. pylori infection affects gastric environments for persistence of other gastric microbiota by decreasing of gastric acidity.
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