Sample Helicobacter Pylori
| Project/Area Number |
23590518
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bacteriology (including Mycology)
|
|---|
| Research Institution | Kyorin University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Shinichi 杏林大学, 医学部, 教授 (10137953)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OSAKI Takako 杏林大学, 医学部, 准教授 (90255406)
HANAWA Tomoko 杏林大学, 医学部, 講師 (80255405)
YONEZAWA Hideo 杏林大学, 医学部, 講師 (60453528)
KURATA Satoshi 杏林大学, 医学部, 学内講師 (00383670)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | ヘリコバクター・ピロリ / 胃粘膜 / フローラ / T-RFLP / 胃炎 / 胃癌 |
|---|
| Research Abstract |
Correlation between Helicobacter pylori and gastric microbiota was examined for the patients with chronic gastritis and gastric cancer. It was shown that streptococci were dominant in the patients with gastritis regardless of H. pylori infection and that Atopobacterium, Enterococcus and Lactobacillus were detected only in the H. pylori positive gastritis patients. Gastric microbiota of the patient with gastric cancer was similar to that of H. pylori-negative gastritis patients. By meta-genome analysis, it was shown that Neisseriaceae, Burkholderiaceae and Enterobacteiaceae, Pseudomonadaceae were dominant Proteobacteria for the H. pylori positive and negative patients with gastritis, respectively. These results suggest that H. pylori infection affects gastric environments for persistence of other gastric microbiota by decreasing of gastric acidity.
|
Report
(4 results)
Research Products
(96 results)
-
-
[Journal Article] Development of a PCR method for the detection of Helicobacter suis in gastric biopsy specimens.2014
Author(s)
Matsui H, Takahashi T, Yamagata-Murayama S, Uchiyama I, Yamaguchi K, Shigenobu S, Matsumoto T, Kawakubo M, Ota H, Osaki T, Kamiya S, Takahashi S, Nakamura S, Nakamura M
-
Journal Title
Helicobacter
Volume: in press
Issue: 4
Pages: 260-271
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Anacardic acid, a histone acetyltransferase inhibitor, modulates LPS-induced IL-8 expression in a human alveolar epithelial cell line A549.2013
Author(s)
Yasutake T, Wada H, Higaki M, Nakamura M, Honda K, Watanabe M, Ishii H, Kamiya S, Takizawa H, Goto H
-
Journal Title
F1000Res
Volume: 2
Pages: 78-78
DOI
Related Report
Peer Reviewed
-
-
-
-
-
[Journal Article] Ciliates expel environmental Legionella-laden pellets to stockpile food.2012
Author(s)
Fuhito Hojo, Daisuke Sato, Junji Matsuo, Masaki Miyake, Shinji Nakamura, Miyuki Kunichika, Yasuhiro Hayashi, Mitsutaka Yoshida, Kaori Takahashi, Hiromu Takemura, Shigeru Kamiya and Hiroyuki Yamaguchi
-
Journal Title
Appl. Environ. Microbiol.
Volume: 78
Issue: 15
Pages: 5247-5257
DOI
Related Report
Peer Reviewed
-
[Journal Article] Destructive effects of butyrate on the cell envelope of Helicobacter pylori2012
Author(s)
Yonezawa H, Osaki T, Hanawa T, Kurata S, Zaman C, Woo TDH, Takahashi M, Matsubara S, Kawakami H, Ochiai K, Kamiya S
-
Journal Title
J Med Microbiol
Volume: 61
Issue: 4
Pages: 582-589
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Cliniates promote the transfer of the gene encoding the extended-spectrum beta-lactamase CTX-M-2 between Escherichia coli strains.2011
Author(s)
Oguri S, Matsuo J, Hayashi Y, Nakamura S, Hanawa T, Fukumoto T, Mizutani Y, Yao T, Akizawa K, Suzuki H, Shimizu C, Matsuno K, Kamiya S, Yamaguchi H
-
Journal Title
J Antimicrob Chemother
Volume: 66(3)
Issue: 3
Pages: 527-530
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Identification of a mechanism for lung inflammation caused by Mycoplasma pneumoniae using a novel mouse model.2011
Author(s)
Saraya T, Nakata K, Nakagaki K, Motoi N, Iihara K, Fujioka Y, Oka T, Kurai D, Wada H, Ishii H, Taguchi H, Kamiya S, Goto H
-
Journal Title
Results in Immunology
Volume: 1(1)
Pages: 76-87
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] Increased germination activity of Clostridium difficile strains isolated from the patients with recurrent infection with C. diffcile.2012
Author(s)
Oka K, Osaki T, Hanawa T, Kurata S, Okazaki M, Manzoku T, Takahashi M, Tanaka M, Taguchi H, Watanabe T, Inamatsu T, Kamiya S
Organizer
The 35th Annual Meeting of the Society for Microbial Ecology in Health and Diseases
Place of Presentation
Valencia, Spain
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
