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Integrated analysis of translocation of Pseudomonas aeruginosa from the colonized gastrointestinal tract

Research Project

Project/Area Number 23590523
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including Mycology)
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

GOTOH Naomasa  京都薬科大学, 薬学部, 教授 (30121560)

Co-Investigator(Kenkyū-buntansha) OKUDA Jun  香川県立保健医療大学, 保健医療学部, 教授 (90334276)
MINAGAWA Shu  京都薬科大学, 薬学部, 助教 (50445962)
HAYASHI Naoki  京都薬科大学, 薬学部, 助教 (70707463)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords緑膿菌 / バクテリアルトランスロケーション / ムチン層 / シデロフォア / mucD遺伝子 / 鞭毛 / トランスロケーション / 比較ゲノム解析 / セリンプロテアーゼ / III型分泌機構 / 上皮細胞層 / ExoS / MucD / 細胞層透過
Research Abstract

In this study, our findings provided at least three new mechanisms for translocation of Pseudomonas aeruginosa from the colonized gastrointestinal tract: (i) the pyoverdine synthesis gene (pvdE) facilitates penetration of P. aeruginosa through the epithelial cell barrier depending on regulating the expression of the exoS gene, impairs the defense function of tight junctions; (ii) P. aeruginosa can degrade interleukin-8 (IL-8) following the expression of the exoS and mucD gene; (iii) P. aeruginosa can penetrate the mucus layer using the flagellar motility and the mucin degradation. These results revealed that functions of P. aeruginosa can penetrate mucus layer and epithelial cells junction, which serve as important barriers in the intestinal epithelial tissue, and a survival strategy of P. aeruginosa to the host immune system.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (65 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 11 results,  Open Access: 1 results) Presentation (52 results) Remarks (1 results)

  • [Journal Article] ExoS of Pseudomonas aeruginosa binds to a human KIF7 to induce cytotoxicity in cultured human bronchial epithelial cells.2014

    • Author(s)
      Okuda, J., Hanabusa, A., and Gotoh, N.
    • Journal Title

      J. Infect. Chemother.

      Volume: 20 Issue: 2 Pages: 121-127

    • DOI

      10.1016/j.jiac.2013.09.001

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pseudomonas aeruginosa MucD protease mediate keratitis by inhibition of neutrophil recruitment and bacterial survival.2014

    • Author(s)
      Mochizuki, Y., Suzuki, T., Oka, N., Zhang, Y., Hayashi, Y., Hayashi, N., Gotoh, N., and Ohashi, Y.
    • Journal Title

      Invest. Ophthalmol. Vis. Sci.

      Volume: 55 Issue: 1 Pages: 240-246

    • DOI

      10.1167/iovs.13-13151

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of antibiotic resistance and sequence type of Acinetobacter baumannii clinical isolates in Japan and the antibacterial activity of DS-8587.2014

    • Author(s)
      Higuchi, S., Shikata, M., Chiba, M., Hoshino, K., and Gotoh, N.
    • Journal Title

      J. Infect. Chemother.

      Volume: 20 Issue: 4 Pages: 256-261

    • DOI

      10.1016/j.jiac.2013.12.001

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of type III effector secretion by polymers.2013

    • Author(s)
      Ohgita, T., Hayashi, N., Gotoh, N., and Kogure, K.
    • Journal Title

      Open Biol.

      Volume: 3 Issue: 12 Pages: 130133-130133

    • DOI

      10.1098/rsob.130133

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel effector secretion mechanism based on proton-motive force-dependent type III secretion apparatus rotation.2013

    • Author(s)
      Ohgita, T., Hayashi, N., Hama, S., Tsuchiya, H., Gotoh, N., and Kogure, K.
    • Journal Title

      FASEB. J.

      Volume: 27 Issue: 7 Pages: 2862-2872

    • DOI

      10.1096/fj.13-229054

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interplay of flagellar motility and mucin degradation by MucD stimulates the association of Pseudomonas aeruginosa with human epithelial colorectal adenocarcinoma (Caco-2) cells.2013

    • Author(s)
      Hayashi, N., Matsukawa, M., Horinishi, Y., Nakai, K., Shoji, A., Yoneko, Y., Yoshida, S., Minagawa, S., Gotoh, N.
    • Journal Title

      J. Infect. Chemother.

      Volume: 19 Issue: 2 Pages: 305-315

    • DOI

      10.1007/s10156-013-0554-4

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Type IV pilus protein PilA of Pseudomonas aeruginosa modulates calcium signaling through binding the calcium-modulating cyclophilin ligand.2013

    • Author(s)
      Okuda, J., Hayashi, N., Arakawa, M., Minagawa, S., and Gotoh, N.
    • Journal Title

      J. Infect. Chemother.

      Volume: 19 Issue: 4 Pages: 653-654

    • DOI

      10.1007/s10156-012-0536-y

    • NAID

      10031194393

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Potent in vitro antibacterial activity of DS-8587, a new generation of broad spectrum quinolone, against Acinetobacter baumannii.2013

    • Author(s)
      Higuchi, S., Onodera, Y., Chiba, M., Hoshino, K., and Gotoh, N.
    • Journal Title

      Antimicrob. Agents Chemother.

      Volume: 57 Issue: 4 Pages: 1978-1981

    • DOI

      10.1128/aac.02374-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neutrophil-derived tumor necrosis factor-α contributes to acute wound healing promoted by N-(3-oxododecanoyl)-l-homoserine lactone from Pseudomonas aeruginosa.2013

    • Author(s)
      Kanno, E., Kawakami, K, Miyairi, S., Tanno, H., Otomaru, H., Hatanaka, A., Sato, S., Ishii, K., Hayashi, D., Shibuya, N., Imai, Y., Gotoh, N., Maruyama, R., and Tachi, M.
    • Journal Title

      J. Dermatol. Sci.

      Volume: 70 Issue: 2 Pages: 130-138

    • DOI

      10.1016/j.jdermsci.2013.01.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complementation of the exoS gene in the pvdE pyoverdine synthesis gene-deficient mutant of Pseudomonas aeruginosa results in recovery of the pvdE gene-mediated penetration through the intestinal epithelial cell barrier but not the pvdE-mediated virulence in silkworms2012

    • Author(s)
      Okuda J., Okamoto M., Hayashi N., Sawada S., Minagawa S., and Gotoh N.
    • Journal Title

      J. Infect. Chemother

      Volume: 18 Issue: 3 Pages: 332-340

    • DOI

      10.1007/s10156-011-0340-0

    • NAID

      10030787228

    • Related Report
      2013 Final Research Report
  • [Journal Article] Complementation of the exoS gene in the pvdE pyoverdine synthesis gene-deficient mutant of Pseudomonas aeruginosa results in recovery of the pvdE gene-mediated penetration through the intestinal epithelial cell barrier but not the pvdE-mediated virulence in silkworms.2012

    • Author(s)
      Okuda, J., Okamoto, M., Hayashi, N., Sawada, S., Minagawa, S., Gotoh, N.
    • Journal Title

      J. Infect. Chemother.

      Volume: 18 Issue: 6 Pages: 332-340

    • DOI

      10.1007/s10156-011-0257-7

    • NAID

      10030787228

    • Related Report
      2013 Final Research Report 2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] In vitro and in vivo antibacterial activity of modithromycin against streptococci and Haemophilus influenzae.2011

    • Author(s)
      Sato, T., Kawai, Y., Matsuda, H., Tateda, K., Kimura, S., Ishii, Y., Yamaguchi, K., Gotoh, N.
    • Journal Title

      J. Antimicrob. Chemother.

      Volume: 66 Issue: 7 Pages: 1547-1554

    • DOI

      10.1093/jac/dkr161

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 緑膿菌の上皮細胞層透過における鞭毛の役割2014

    • Author(s)
      成宮久美、林直樹、米子佳希、後藤直正
    • Organizer
      日本薬学会134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 緑膿菌の腸管経由血液感染における鞭毛運動の必要性2013

    • Author(s)
      米子佳希、林直樹、皆川周、後藤直正
    • Organizer
      第61回日本化学療法学会西日本支部総会第56回日本感染症学会中日本地方会学術集会第83回日本感染症学会西日本地方会学術集会共同開催
    • Place of Presentation
      大阪
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 鞭毛とプロテアーゼの協力的作用によって緑膿菌は宿主細胞ムチン層を透過する2013

    • Author(s)
      林直樹、西澤英之、北尾聖哉、出口桜子、中井勝也、吉田奈緒美、皆川周、後藤直正
    • Organizer
      第25回微生物シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2013-09-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Interplay of flagellar motility and mucin degradation stimulates the association of Pseudomonas aeruginosa through the mucin layer2013

    • Author(s)
      Naoki Hayashi, Mariko Matsukawa, Yuta Horinishi, Katsuya Nakai, Ai Shoji, Yoshiki Yoneko, Naomi Yoshida, Shu Minagawa, and Naomasa Gotoh
    • Organizer
      International Society of Chemotherapy 28th general meeting
    • Place of Presentation
      Yokohama
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Pseudomonas aeruginosaは鞭毛運動およびムチン分解を介してムチン層を透過する2013

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第87回日本感染症学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-06-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Interplay of flagellar motility and mucin degradation by MucD stimulates the association of Pseudomonas aeruginosa with epithelial cells2013

    • Author(s)
      Naoki Hayashi, Mariko Matsukawa, Yuta Horinishi, Katsuya Nakai, Ai Shoji, Yoshiki Yoneko, Naomi Yoshida, Shu Minagawa, and Naomasa Gotoh
    • Organizer
      American society for microbiology 113th general meeting
    • Place of Presentation
      Denver
    • Year and Date
      2013-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Pseudomonas aeruginosaは鞭毛運動およびMucDプロテアーゼによって宿主細胞ムチン層を透過する2013

    • Author(s)
      林直樹、松川真理子、堀西祐多、中井勝也、庄司愛、吉田奈緒美、米子佳希、皆川周、後藤直正
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑膿菌によるムチン層透過機構の解析2013

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第86回日本細菌学会総会
    • Place of Presentation
      千葉
    • Year and Date
      2013-03-18
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 緑膿菌の鞭毛運動とムチン分解によるムチン層透過機構の解析2013

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第47回緑膿菌感染症研究会
    • Place of Presentation
      札幌
    • Year and Date
      2013-02-22
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosaによるムチン層透過機構の解析2012

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第60回日本化学療法学会西日本支部総会第55回日本感染症学会中日本地方会学術集会第82回日本感染症学会西日本地方会学術集会共同開催
    • Place of Presentation
      福岡
    • Year and Date
      2012-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑膿菌によるムチン層透過機構の解析2012

    • Author(s)
      林直樹、堀西祐多、松川真理子、庄司愛、中井勝也、吉田奈緒美、米子佳希、皆川周、後藤直正
    • Organizer
      第24回微生物シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2012-09-04
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Penetration of Pseudomonas aeruginosa through the intestinal epithelial cell mucin barrier2012

    • Author(s)
      Naoki Hayashi, Jun Okuda, Shu Minagawa, Naomasa Gotoh
    • Organizer
      American society for microbiology 112th general meeting
    • Place of Presentation
      San Francisco
    • Year and Date
      2012-06-19
    • Related Report
      2013 Final Research Report
  • [Presentation] タイプIIIエフェクターExoSを介した緑膿菌の組織上皮細胞層透過活性と鉄獲得系遺伝子pvdEを介した病原性との相関2012

    • Author(s)
      奥田潤、林直樹、後藤直正
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2012-04-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 鉄獲得系遺伝子pvdEを介したカイコ致死活性におけるタイプIIIエフェクターExoSの役割2012

    • Author(s)
      奥田潤、岡本将志、林直樹、皆川周、後藤直正
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 鉄獲得系遺伝子pvdEを介したカイコ致死活性におけるタイプIII エフェクターExoSの役割.2012

    • Author(s)
      奥田潤,岡本将志,林直樹,皆川周,後藤直正
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌のムチン層透過機構の解析.2012

    • Author(s)
      林直樹,堀西祐多,松川真理子,庄司愛,皆川周,奥田潤,後藤直正
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌タイプIIIエフェクター ExoS と結合する新規宿主因子の探索.2012

    • Author(s)
      奥田潤,四方基嗣,英麻美,林直樹,皆川周,後藤直正
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of ExoS in penetration of clinical isolates of P. aeruginosa through the epithelial monolsyers.2012

    • Author(s)
      奥田潤, 林直樹, 皆川周, 後藤直正
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌のムチン層透過機構の解明.2012

    • Author(s)
      林直樹, 奥田潤, 皆川周, 後藤直正
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎
    • Related Report
      2011 Research-status Report
  • [Presentation] ムチン分解によるPseudomonas aeruginosaの組織上皮細胞への到達2012

    • Author(s)
      林直樹, 堀西祐多, 松川真理子, 庄司愛, 皆川周, 奥田潤, 後藤直正
    • Organizer
      第46回緑膿菌感染症研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Contribution of flagella to penetration of Pseudomonas aeruginosa through the intestinal epithelial cell mucin barrier2011

    • Author(s)
      Naoki Hayashi, Jun Okuda, Shu Minagawa, and Naomasa Gotoh
    • Organizer
      IUMS 2011 Sapporo
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] タイプIIIエフェクターExoSを介した緑膿菌の腸管上皮細層透過活性はピオベルジン合成遺伝子pvdEを介した病原性と関連する2011

    • Author(s)
      奥田潤、藪内新平、宮本悠佑、岡本将志、林直樹、澤田真嗣、皆川周、後藤直正
    • Organizer
      第23回微生物シンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2011-09-03
    • Related Report
      2013 Final Research Report
  • [Presentation] 比較ゲノム解析を基盤にした緑膿菌の内因性血液感染メカニズムの解明2011

    • Author(s)
      奥田潤, 林直樹, 皆川周, 後藤直正
    • Organizer
      第1回4大学連携研究フォーラム
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌が産生する抗菌性タンパク質pyocin S5 の宿主細胞への影響2011

    • Author(s)
      足立萌, 岡本真由子, 田川優介, 林直樹, 皆川周, 奥田潤, 後藤直正
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌臨床分離株の組織上皮細胞層透過におけるタイプIIIエフェクターExoSの重要性2011

    • Author(s)
      西澤英之, 一色瑞希, 林直樹, 皆川周, 奥田潤, 後藤直正
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌の腸管ムチン分解因子の探索.2011

    • Author(s)
      庄司愛, 吉田奈緒美, 米子佳希, 林直樹, 皆川周, 奥田潤, 後藤直正
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌タイプIIIエフェクターExoSとKIF-7の相互作用についての解析2011

    • Author(s)
      植木彩, 川瀬磨耶, 荒川宗徳, 四方基嗣, 英麻美, 林直樹, 皆川周, 奥田潤, 後藤直正
    • Organizer
      第61回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 緑膿菌の上皮透過機構の解明~上皮細胞への到達と透過について~.2011

    • Author(s)
      林直樹, 奥田潤, 皆川周, 後藤直正
    • Organizer
      第1回 KPUシンポジウム.
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Presentation] タイプIIIエフェクターExoSを介した緑膿菌の腸管上皮細層透過活性はピオベルジン合成遺伝子pvdEを介した病原性と関連する.2011

    • Author(s)
      奥田潤, 藪内新平, 宮本悠佑, 岡本将志, 林直樹, 澤田真嗣, 皆川周, 後藤直正
    • Organizer
      第23回微生物シンポジウム
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] The type III effector ExoS mediates to penetration of Pseudomonas aeruginosa through the tissue epithelial cell barrier.2011

    • Author(s)
      Jun Okuda, Naoki Hayashi, Masashi Okamoto, Asami Hanabusa, Taichirou Tanikawa, Shinji Sawada, Shu Minagawa, Naomasa Gotoh.
    • Organizer
      IUMS 2011
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Contribution of flagella to penetration of Pseudomonas aeruginosa through the intestinal epithelial cell mucin barrier.2011

    • Author(s)
      Naoki Hayashi, Jun Okuda, Shu Minagawa, Naomasa Gotoh.
    • Organizer
      IUMS 2011
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Pseudomonas aeruginosaのムチン層透過機構.2011

    • Author(s)
      林直樹, 奥田潤, 皆川周, 後藤直正
    • Organizer
      第5回細菌学・若手コロッセウム
    • Place of Presentation
      高知
    • Related Report
      2011 Research-status Report
  • [Presentation] Interplay of flagellar motility and mucin degradation by MucD stimulates the association of Pseudomonas aeruginosa with epithelial cells

    • Author(s)
      Naoki Hayashi, Mariko Matsukawa, Yuta Horinishi, Katsuya Nakai, Ai Shoji, Yoshiki Yoneko, Naomi Yoshida, Shu Minagawa, and Naomasa Gotoh.
    • Organizer
      American society for microbiology 113th general meeting
    • Place of Presentation
      Denver
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pseudomonas aeruginosa は鞭毛運動およびムチン分解を介してムチン層を透過する

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第87回日本感染症学会総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interplay of flagellar motility and mucin degradation stimulates the association of Pseudomonas aeruginosa through the mucin layer

    • Author(s)
      Naoki Hayashi, Mariko Matsukawa, Yuta Horinishi, Katsuya Nakai, Ai Shoji, Yoshiki Yoneko, Naomi Yoshida, Shu Minagawa, and Naomasa Gotoh
    • Organizer
      International Society of Chemotherapy 28th general meeting
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 鞭毛とプロテアーゼの協力的作用によって緑膿菌は宿主細胞ムチン層を透過する

    • Author(s)
      林直樹、西澤英之、北尾聖哉、出口桜子、中井勝也、吉田奈緒美、皆川周、後藤直正
    • Organizer
      第25回 微生物シンポジウム
    • Place of Presentation
      静岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pseudomonas aeruginosaの上皮細胞層透過機構における鞭毛運動の役割

    • Author(s)
      出口桜子、山口志織、西澤英之、北尾聖哉、皆川周、林直樹、後藤直正
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pseudomonas aeruginosaの上皮細胞付着に対する上皮細胞種特異性

    • Author(s)
      古曽志まり子、占部湖太郎、吉田奈緒美、皆川周、林直樹、後藤直正
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオイメージングを利用したPseudomonas aeruginosaの上皮細胞層透過機構の解析

    • Author(s)
      森田眞由、浅野美香、米子佳希、皆川周、林直樹、後藤直正
    • Organizer
      第63回日本薬学会近畿支部総会・大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑膿菌の腸管経由血液感染における鞭毛運動の必要性

    • Author(s)
      米子佳希、林直樹、皆川周、後藤直正
    • Organizer
      第61回日本化学療法学会西日本支部総会 第56回日本感染症学会中日本地方会学術集会 第83回日本感染症学会西日本地方会学術集会 共同開催
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑膿菌による上皮細胞層透過機構の解析

    • Author(s)
      林直樹、西澤英之、北尾聖哉、出口桜子、中村貴乃、藤本祥代、四方基嗣、後藤直正
    • Organizer
      第3回4大学連携研究フォーラム
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] タイプ III エフェクター ExoS を介した緑膿菌の組織上皮細胞層透過活性と鉄獲得系遺伝子 pvdEを介した病原性との相関

    • Author(s)
      奥田潤、林直樹、後藤直正
    • Organizer
      第86回日本感染症学会総会
    • Place of Presentation
      長崎
    • Related Report
      2012 Research-status Report
  • [Presentation] Penetration of Pseudomonas aeruginosa through the intestinal epithelial cell mucin barrier.

    • Author(s)
      Naoki Hayashi, Jun Okuda, Shu Minagawa, Naomasa Gotoh.
    • Organizer
      American society for microbiology 112th general meeting
    • Place of Presentation
      San Francisco
    • Related Report
      2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosa による上皮細胞層透過機構の解析

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第6回細菌学・若手コロッセウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑膿菌による上皮細胞層透過機構の解析

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第11回次世代を担うファーマ・バイオフォーラム2012
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑膿菌のMucDセリンプロテアーゼによるムチン分解機構の解析

    • Author(s)
      高石彩香、中井勝也、吉田奈緒美、松川真理子、林直樹、皆川周、後藤直正
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] 緑膿菌のべん毛運動を介したムチン層透過機構の解析

    • Author(s)
      成宮久美、庄司愛、米子佳希、堀西祐多、林直樹、皆川周、後藤直正
    • Organizer
      第62回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosa によるムチン層透過機構の解析

    • Author(s)
      林直樹、皆川周、後藤直正
    • Organizer
      第60回日本化学療法学会西日本支部総会 第55 回日本感染症学会中日本地方会学術集会 第82 回日本感染症学会西日本地方会学術集会 共同開催
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosa は鞭毛運動およびMucDプロテアーゼによって宿主細胞ムチン層を透過する

    • Author(s)
      林直樹、松川真理子、堀西祐多、中井勝也、庄司愛、吉田奈緒美、米子佳希、皆川周、後藤直正
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ゲノム情報を基盤としたPseudomonas aeruginosaが産生するムチン分解性プロテアーゼの探索

    • Author(s)
      高石彩香、林直樹、松川真理子、中井勝也、吉田奈緒美、皆川周、後藤直正
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosa の宿主細胞ムチン層透過における鞭毛の役割の評価

    • Author(s)
      成宮久美、林直樹、堀西祐多、庄司愛、米子佳希、皆川周、後藤直正
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] Pseudomonas aeruginosa の鞭毛と線毛を介した上皮細胞層透過機構の解析

    • Author(s)
      西澤英之、林直樹、北尾聖哉、出口桜子、皆川周、後藤直正
    • Organizer
      日本薬学会133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Remarks] 京都薬科大学微生物・感染制御学分野

    • URL

      http://www.kyoto-phu.ac.jp/labo/bisei/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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