| Project/Area Number |
23590525
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
|
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| Research Institution | Kyushu Women's University (2013)
Kawasaki Medical School (2011-2012) |
|---|
Principal Investigator |
MIURA Koshiro 九州女子大学, 家政学部, 教授 (30284243)
|
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| Co-Investigator(Kenkyū-buntansha) |
岸 文雄 川崎医科大学, 医学部, 教授 (40153077)
簗取 いずみ 川崎医科大学, 医学部, 講師 (40454847)
|
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | Chlamydia pneumoniae / 肺炎クラミジア / アポトーシス |
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| Research Abstract |
We isolated two genes of Chlamyida pneuminiae suppressing apoptosis of yeast cells. However, these results were not obtained reproducibly.
Fke034 was one of the candidate genes of chlamydial effectors. We confirmed secretion of the gene product from the bacteria into host cell, located peripherally. Expression of the Fke034 promoted host cell apoptosis. We revealed interaction in vitro between the Fke034 protein and PACSIN2, and co-localization of them in infected cells. These findings suggest that Fke034 protein leads PACSIN2 peripherally to regulate the function of PACSIN2.
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