| Project/Area Number |
23590530
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | レジオネラ / Legionella pneumophila / sequence-based typing / 遺伝子型別 / 浴槽水 / 冷却塔水 / 土壌 / 遺伝子型 / SBT / 臨床分離株 / Seqence-based typing / モノクローナル抗体 |
|---|
| Research Abstract |
Legionella pneumophila (Lp), the causative agent of Legionnaires' disease, grows in the bath water. Over half of Legionella pneumonia patients, however, do not use the bathing facility, and in most such cases, the sources of infection are not clear. I examined the genotypes of Lp strains derived from various environments: cooling tower water, soil, fountains, and shower water as well as bath water, in order to compare the genotypes of Lp strains derived from patients. The genotypes of Lp strains derived from patients who were suspected to infect Lp through bath water were belonged to the genotype groups including most Lp strains derived from bath water. The genotypes of Lp strains derived from patients whose sources of infection were unknown were belonged to the genotype groups including Lp strains derived from environments other than bath water. Therefore inspection and hygiene management of various environments other than bathing facilities as the source of infection are important.
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