| Project/Area Number |
23590532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Clinical Research Center, National Hospital Organization, Kinki-Chuo Chest Medical Center |
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Principal Investigator |
OKADA Masaji 独立行政法人国立病院機構(近畿中央胸部疾患センター臨床研究センター), その他部局等, その他 (40160684)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Katsuhiro 国立病院機構近畿中央胸部疾患センター, 統括診療部長 (00206468)
TSUYUGUCHI Kazunari 国立病院機構近畿中央胸部疾患センター, 臨床研究センター, 感染症研究部長 (00359308)
YOSHIDA Shigeto 金沢大学, 医薬保健研究域薬学系, 教授 (10296121)
OHARA Naoya 岡山大学, 大学院医歯薬学総合研究科, 教授 (70223930)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 結核ワクチン / Granulysin / granulysinレセプター / キラーT細胞分化 / 結核予防ワクチン / 結核治療ワクチン / ポジティブフィードバック / レセプター単離 / HSP65タンパク |
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| Research Abstract |
Cytotoxic T cells against M. tuberculosis are one of most important immune cells for the protection of tuberculosis infection in human.
(1)It was demonstrated first that HSP65 DNA+IL-12 DNA vaccine (HSP65 vaccine) and 15K Granulysin vaccine exerted the activity of cytotoxic T cell differentiation factor in the present study. (2)Therefore, the presence of the receptor for granulysin was strongly suggested. We are now isolating the granulysin receptor. (3)We found granulysin-granulysin positive feedback loop. Granulysin was produced from CTL, and granulysin act on the differentiation of CTL. (4)HSP65 vaccine and Granulysin vaccine exerted synergistic therapeutic efficacy against TB infection in mice, and showed the synergistic differentiation of CTL.
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Report
(4 results)
Research Products
(78 results)
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[Journal Article] Potential function of granulysin, other related effector molecules and lymphocyte subsets in patients with TB and HIV/TB coinfection.2013
Author(s)
1)Pitabut N, Sakurada S, Tanaka T, Ridruechai C, Tamura J, Aoki T, Kantipong P, Piyawarawong S, Kobayashi N, Dhepakson P, Yanai H, Yamada N, Oka S, Okada M, Khusmith S, Keicho N
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Journal Title
International Journal of Medical Sciences
Volume: 10(8)
Pages: 1003-1014
Related Report
Peer Reviewed
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[Journal Article] The study of novel DNA vaccines against tuberculosis: Induction of pathogen-specific CTL in the mouse and monkey models of tuberculosis.2013
Author(s)
Okada, M., Y. Kita, T. Nakajima, S. Hashimoto, H. Nakatani, S. Nishimatsu, Y. Nishida, N. Kanamaru, Y. Kaneda, Y. Takamori, D. McMurray, E V.Tan, M L. Cang, P. Saunderson, and E.C.Dela Cruz
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Journal Title
Human Vaccines and Immunotherapeutics
Volume: 9(3)
Pages: 515-525
Related Report
Peer Reviewed
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[Journal Article] Novel therapeutic vaccines [(HSP65+IL-12)DNA-, granulysin- and Ksp37-vaccine] against tuberculosis and synergistic effects in the combination with chemotherapy.2013
Author(s)
2) Kita, Y., S. Hashimoto, T. Nakajima, H. Nakatani, S. Nishimatsu, Y. Nishida, N. Kanamaru, Y. Kaneda, Y. Takamori, D. McMurray, E V.Tan, M L. Cang, P. Saunderson, E.C.Dela Cruz, M. Okada.
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Journal Title
Human Vaccines and Immunotherapeutics
Volume: 9(3)
Pages: 526-533
Related Report
Peer Reviewed
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[Journal Article] Novel prophylactic vaccine using a prime-boost method and hemagglutinating virus of Japan-envelope against tuberculosis.2011
Author(s)
Okada M, Kita Y, Nakajima T, Kanamaru N,Hashimoto S, Nagasawa T, Kaneda Y, Yoshida S, Nishida Y, Nakatani H, Takao K, Kishigami C, Nishimatsu S, Sekine Y, Inoue Y, McMurray DN , Sakatani M
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Journal Title
Clin Dev Immunol
Volume: -
Related Report
Peer Reviewed
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[Journal Article] Decreased plasma granulysin and increased interferon-gamma concentrations in patients with newly diagnosed and relapsed tuberculosis.2011
Author(s)
Pitabut N, Mahasirimongkol S, Yanai H, Ridruechai C, Sakurada S, Dhepakson P, Kantipong P, Piyaworawong S, Moolphate S, Hansudewechakul C, Yamada N, Keicho N, Okada M, Khusmith S
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Journal Title
Microbiol Immunol
Volume: 55(8)
Pages: 565-573
NAID
Related Report
Peer Reviewed
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[Presentation] A novel therapeutic vaccine against tuberculosis in the cynomolgus monkey model and clinical trial.2013
Author(s)
Okada M, Nakajima T, Kaneda Y, Tan E.V, McMurray D, Inoue Y, Tomono K, Kumanogo A, Tuyuguchi K, Shoji S, Mikami R, Matsumoto T, Saito T
Organizer
7th Vaccine ＆ISV Congress
Place of Presentation
Barcelona, Spain
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[Presentation] A Novel Therapeutic Vaccine (HVJ-Envelope/HSP65 DNA+IL-12 DNA) against Tuberculosis by the Augmentation of Immune Responses Using Monkey Models2011
Author(s)
Okada, Y Kita, N Kanamaru, S Hashimoto, S Nishimatsu,T Nakajima, Y Kaneda, P Saunderson, E V.Tan, D McMurray
Organizer
51th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy)
Place of Presentation
Chicago, USA
Related Report
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[Presentation] 結核医療におけるチェンジとチャレンジ 新しい結核予防・治療ワクチンの開発(ヒト結核モデルに最も近いカニクイザルを用いた)2011
Author(s)
橋元里実, 喜多洋子, 金丸典子, 高見泰子, 仲谷均, 岸上知恵, 西松志保, 名倉香織, 林清二, 吉田栄人, 中島俊洋, 金田安史, TanE.V., ポール・サウンダーソン, 岡田全司
Organizer
国立病院総合医学会
Place of Presentation
岡山
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[Presentation] Novel therapeutic vaccines against tuberculosis and their synergistic efficacy using chemotherapy.
Author(s)
14) Okada, M., Y. Kita, N. Kanamaru, S. Hashimoto, S. Nishimatsu, T. Nakajima, Y. Kaneda, P. Saunderson, E V.Tan
Organizer
The 43rd Union World Conference on Lung Health (International Union Against Tuberculosis and Lung Disease)
Place of Presentation
Kuala Lumpur, Malaysia
Related Report
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