| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Chimeric analysis of the F proteins of the parainfluenza virus 5 and simian virus 41 revealed that 21 amino acids in the five domains on the surface of the F protein head region are involved in functional interaction with the HN protein stalk region, leading to the induction of cell-cell fusion. Furthermore, it was suggested that this functional interaction is dependent on the conformation of the HN stalk region.
On the other hand, the results obtained from bimolecular fluorescence complementation analysis indicated that physical interaction between HN and F protein is not only dependent on the proteolytic cleavage of the F protein but also on the conformational change of the F protein. However, it was suggested that under physiological conditions his physical interaction is weak in its avidity or takes place very transiently.
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