| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The infection of HPV is a major risk factor for cervical cancers and some of head and neck squamous cell carcinomas. For prevention of these cancers, it is critical to develop effective anti-virus reagents. In this project, I examined the mechanisms of virus replication and virus-induced tumorigenesis for identification of the candidate targets for anti-virus reagents.
It was revealed that E6 was important for the genome maintenance of HPV and that E7 was critical both for the virus-induced tumorigenesis and vegetative virus replication.
These results indicates that both E6 and E7 are good candidates for the developing anti-virus reagents. For the identification of the reagents, it is essential to clarify the action mechanisms of these oncoproteins.
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