Understandings of the HPV-induced tumorigenesis for developing anti-virus reagents.
Project/Area Number |
23590540
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Virology
|
Research Institution | Kyoto University |
Principal Investigator |
SAKAI Hiroyuki 京都大学, ウイルス研究所, 准教授 (80281731)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | HPV / 腫瘍形成 / 抗ウイルス剤 / 子宮頸癌 / パピローマウイルス / ウイルス発がん / human papillomavirus / 重層上皮形成 |
Research Abstract |
The infection of HPV is a major risk factor for cervical cancers and some of head and neck squamous cell carcinomas. For prevention of these cancers, it is critical to develop effective anti-virus reagents. In this project, I examined the mechanisms of virus replication and virus-induced tumorigenesis for identification of the candidate targets for anti-virus reagents. It was revealed that E6 was important for the genome maintenance of HPV and that E7 was critical both for the virus-induced tumorigenesis and vegetative virus replication. These results indicates that both E6 and E7 are good candidates for the developing anti-virus reagents. For the identification of the reagents, it is essential to clarify the action mechanisms of these oncoproteins.
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Report
(4 results)
Research Products
(21 results)