| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We identified stress granule components as the hepatitis C virus (HCV) genome regulatory proteins. Notably, we noticed that HCV infection induces stress granules 36h post-infection. Furthermore, HCV hijacked these stress granule components, including G3BP1, ataxin-2, poly(A)-binding protein (PABP)-1, around lipid droplets. Importantly, HCV replication was significantly suppressed in these knockdown cells. Thus, we suggested that stress granule components are required for HCV replication.
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