Study on regulatory mechanism of RNA viral genome by cellular bodies
| Project/Area Number |
23590545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kumamoto University |
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Principal Investigator |
ARIUMI YASUO 熊本大学, エイズ学研究センター, 准教授 (60303913)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | HCV / P-pody / ストレス顆粒 / RNAヘリケース / APOBEC3G / HIV-1 / DDX21 / 核小体 / Staufen-1 / UPF-1 / HIV Rev / DDX3 / P-body / 宿主因子 / MOV10 / 国際研究者交流 / スイス |
|---|
| Research Abstract |
We identified stress granule components as the hepatitis C virus (HCV) genome regulatory proteins. Notably, we noticed that HCV infection induces stress granules 36h post-infection. Furthermore, HCV hijacked these stress granule components, including G3BP1, ataxin-2, poly(A)-binding protein (PABP)-1, around lipid droplets. Importantly, HCV replication was significantly suppressed in these knockdown cells. Thus, we suggested that stress granule components are required for HCV replication.
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Report
(4 results)
Research Products
(71 results)
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[Journal Article] Distinct HIV-1 escape patterns selected by CTLs with identical epitope specificity2013
Author(s)
Yagita Y, Kuse N, Kuroki K, Gatanaga H, Carlson J, Chikata T, Brumme Z, Murakoshi H, Akahoshi T, Pfeifer N, Mallal S, John M, Ose T, Matsubara H, Kanda R, Fukunaga Y, Honda K, Kawashima Y, Ariumi Y, Oka S, Maenaka K, Takiguchi M
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Journal Title
J. Virol
Volume: 87
Pages: 2253-2263
Related Report
Peer Reviewed
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[Journal Article] Anti-ulcer agent teprenone inhibits hepatitis C virus replication : potential treatment for hepatitis C2011
Author(s)
Ikeda M, Kawai Y, Mori K, Yano M, Abe K, Nishimura G, Dansako H, Ariumi Y, Wakita T, Yamamoto K, Kato N
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Journal Title
Liver Int
Volume: 31(6)
Pages: 871-880
Related Report
Peer Reviewed
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[Presentation] HIV-1 interacts with LINE-12014
Author(s)
Kodai Kawano, Misao Kuroki, Yasuo Ariumi
Organizer
Keystone symposia Mobile Genetic Elements and Genome Evolution (C2)
Place of Presentation
Santa Fe, New Mexico, USA
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