| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
The ability of mammalian cytidine deaminases encoded by the APOBEC3 (A3) genes to restrict a broad range of endogenous retroelements as well as exogenous retroviruses such as HIV-1 is now well established. We observed that APOBEC1, which mediates C-to-U deamination of apo B mRNA and is involved in lipid transport, from rodents and non-placental mammals, such as opossum are also powerful inhibitors of retroelements including HIV-1. Accordingly, we will test the hypothesis that APOBEC1 knock-out to evade species-specific intrinsic restriction factors in mice will markedly increase their susceptibility to HIV-1 challenge.
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