Research in anti-retroviral intrinsic immunity using APOBEC1 knock-out mice
| Project/Area Number |
23590546
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kumamoto University |
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Principal Investigator |
KOITO ATSUSHI 熊本大学, 大学院生命科学研究部, 研究員 (70231305)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レトロウイルス / シチジン脱アミノ化酵素 / レトロエレメント / HIV / 小動物モデル / ゲノム / APOBEC |
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| Research Abstract |
The ability of mammalian cytidine deaminases encoded by the APOBEC3 (A3) genes to restrict a broad range of endogenous retroelements as well as exogenous retroviruses such as HIV-1 is now well established. We observed that APOBEC1, which mediates C-to-U deamination of apo B mRNA and is involved in lipid transport, from rodents and non-placental mammals, such as opossum are also powerful inhibitors of retroelements including HIV-1. Accordingly, we will test the hypothesis that APOBEC1 knock-out to evade species-specific intrinsic restriction factors in mice will markedly increase their susceptibility to HIV-1 challenge.
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Report
(4 results)
Research Products
(40 results)
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[Journal Article] Intrinsic restriction activity by apolipoprotein B mRNA editing enzyme APOBEC1 against the mobility of autonomous retrotransposons2011
Author(s)
Ikeda, T., Abd El Galil, K., Tokunaga, K., Maeda, K., Sata, T., Sakaguchi, N., Harada, S., Heidmann, T., Koito, A.
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Journal Title
Nucleic Acids Res
Volume: 39
Issue: 13
Pages: 5538-54
DOI
Related Report
Peer Reviewed
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[Presentation] Role of mammalian TREX-2 component GANP in HIV-1 infection2013
Author(s)
Maeda K, Almofty SA, Singh SK, Eid MMA, Shimoda M, Ikeda T, Shida H, Koito A, Pham P, Goodman MF, and Sakaguchi N.
Organizer
14th. Kumamoto AIDS Seminar
Place of Presentation
Kumamoto, Japan
Related Report
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[Presentation] Role of mammalian TREX-2 component GANP in HIV-1 infection2013
Author(s)
Maeda K, Almofty SA, Singh SK, Eid MMA, Shimoda M, Ikeda T, Shida H, Koito A, Pham P, Goodman MF, and Sakaguchi N.
Organizer
14th. Kumamoto AIDS Seminar.
Place of Presentation
Aso Resort Grandvrio Hotel, Kumamoto, Japan
Related Report
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[Presentation] Mamalian TREX-2 component GANP is involved in HIV-1 mRNA export2012
Author(s)
Maeda K, Almofty SA, Singh SK, Eid MMA, Shimoda M, Ikeda T, Shida H, Koito A, Pham P, Goodman MF, and Sakaguchi N.
Organizer
13th. Kumamoto AIDS Seminar GCOE Joint International Symposium
Place of Presentation
Kumamoto, Japan
Related Report
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[Presentation] GANP associated with HIV-1 RNA export is encapsidated with Apobec3G into virion cores2011
Author(s)
Maeda K, Singh SK, Sarah A, Eid MM, Ikeda T, Pham P, Goodman MF, Koito A, Sakaguchi N.
Organizer
Cold Spring Harbor Laboratory, Meeting on Retroviruses
Place of Presentation
Cold Spring Harbor, NY USA
Related Report
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