Impact of hepatitis C virus infection in B cells on pathogenesis

• Project/Area Number: 23590547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Virology
• Research Institution: Kagoshima University
• Principal Investigator: KOHARA Kyoko 鹿児島大学, 獣医学部, 教授 (20225478)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: C型肝炎ウイルス / Bリンパ腫 / microarray / A20 / NF-kB / miR-26b / Ｂリンパ腫 / トランスジェニックマウス / microRNA

Research Abstract

Hepatitis C virus (HCV) infection leads to the development of hepatic diseases, as well as extra hepatic disorders such as B-cell non-Hodikin's lymphoma (B-NHL). To reveal the molecular signaling pathways responsible for HCV-associated B-NHL development, we utilized transgenic (Tg) mice that express the full-length HCV genome specifically in B cells and develop non-Hodgkin type B-cell lymphomas (BCLs). The gene expression profiles in B cells from BCL-developing HCV-Tg mice, from BCL-non-deceloping HCV-Tg mice, and from BCL-non-developing HCV-negative mice were analyzed by genome-wide microarray.
Markedly modified genes such as Fos, C3, LTbR, A20, NF-kB and miR-26b in BCLs were further characterized using specific assays. We propose that activation of both canonical and alternative NF-kB signaling pathways and down-regulation of miR-26b contribute to the development of HCV-associated B-NHL.

Research Products

• [Journal Article] B-cell-intrinsic hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling (2014)
  • Author(s): Kasama Y, Mizukami T, Kusunoki H, Peveling-Oberhag J, Nishito Y, Ozawa M, Kohara M, Mizuochi T, Tsukiyama-Kohara K
  • Journal Title: PLoS One Volume: 9(3) Issue: 3 Pages: 91373-91373
  • DOI: 10.1371/journal.pone.0091373
  • Peer Reviewed / Open Access
• [Journal Article] Recent insights into hepatitis B virus-host interactions. (2014)
  • Author(s): Ezzikouri S, Ozawa M, Kohara M, Elmdaghri N, Benjelloun S, Tsukivama-Kohara K.
  • Journal Title: Journal of Medical Virology Volume: 86 Issue: 6 Pages: 925-32
  • DOI: 10.1002/jmv.23916
  • Peer Reviewed / Open Access
• [Journal Article] B-cell-intrinsic Hepatitis C virus expression leads to B-cell-lymphomagenesis and induction of NF-κB signalling. (2014)
  • Author(s): Kasama Y, Mizukami T, Kusunoki H, Peveling-Oberhag J, Nishito Y, Ozawa M, Kohara M, Mizuochi T, Tsukiyama-Kohara K.
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] Recent insights into hepatitis B virus-host interactions. (2014)
  • Author(s): Ezzikouri S, Ozawa M, Kohara M, Elmdaghri N, Benjelloun S, Tsukiyama-Kohara K.
  • Journal Title: J Med Virol. Volume: 86 Pages: 925-932
  • Peer Reviewed
• [Journal Article] Tupaia belangeri as an experimental animal model for viral infection (2014)
  • Author(s): Tsukiyama-Kohara K, Kohara M
  • Journal Title: Exp Animal Volume: accepted
  • Peer Reviewed
• [Journal Article] Resistance to cyclosporin A derives from mutations in Hepatitis C virus nonstructural proteins (2014)
  • Author(s): Arai, M., Tsukiyama-Kohara, K., Takagi, A., Tobita, Y., Inoue, K., Kohara, M.
  • Journal Title: BBRC Volume: accepted
  • Peer Reviewed
• [Journal Article] A serine palmytoiltransferase inhibitor inhibits hepatitis C virus replication in human hepatocytes (2013)
  • Author(s): Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto Y, Kusanagi I, Fujiwara S, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M
  • Journal Title: Gastroenterology Volume: 145(4)(pii : S0016-5085(13)00914-1. 10.1053) Pages: 865-73
• [Journal Article] 4E-BP1 regulates the differentiation of white adipose tissue (2013)
  • Author(s): Tsukiyama-Kohara K, Katsume A, Kimura K, Saito M, Kohara M
  • Journal Title: Genes Cells Volume: 18(7) Issue: 7 Pages: 602-607
  • DOI: 10.1111/gtc.12059
• [Journal Article] Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection (2013)
  • Author(s): Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M
  • Journal Title: PLoS One Volume: 8 Issue: 3 Pages: e59611-e59611
  • DOI: 10.1371/journal.pone.0059611
  • Peer Reviewed
• [Journal Article] Genomic polymorphisms in 3β-hydroxysterol Δ24-reductase promoter sequences. (2013)
  • Author(s): Salem NE, Saito M, Kasama Y, Ozawa M, Kawabata T, Harada S, Suda H, Asonuma K, El-Gohary A, Tsukiyama-Kohara K.
  • Journal Title: Microbiolgy and Immunolgy Volume: 57 Issue: 3 Pages: 179-184
  • DOI: 10.1111/1348-0421.12025
  • Peer Reviewed
• [Journal Article] A serine palmitoyltransferase inhibitor blocks hepatitis C virus replication in human hepatocytes. (2013)
  • Author(s): Katsume A, Tokunaga Y, Hirata Y, Munakata T, Saito M, Hayashi H, Okamoto K, Ohmori Y, Kusanagi I, Fujiwara S, Tsukuda T, Aoki Y, Klumpp K, Tsukiyama-Kohara K, El-Gohary A, Sudoh M, Kohara M.
  • Journal Title: Gastroenterology Volume: 145 Pages: 865-873
  • Peer Reviewed
• [Journal Article] 4E-BP1 regulates the differentiation of white adipose tissue. (2013)
  • Author(s): Tsukiyama-Kohara K, Katsume A, Kimura K, Saito M, Kohara M.
  • Journal Title: Genes Cells. Volume: 18 Pages: 602-607
  • Peer Reviewed
• [Journal Article] Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection. (2013)
  • Author(s): Nakagawa S, Hirata Y, Kameyama T, Tokunaga Y, Nishito Y, Hirabayashi K, Yano J, Ochiya T, Tateno C, Tanaka Y, Mizokami M, Tsukiyama-Kohara K, Inoue K, Yoshiba M, Takaoka A, Kohara M.
  • Journal Title: PLoS One Volume: 8
  • Peer Reviewed
• [Journal Article] 4E-BP1 regulates the differentiation of white adipose tissue (2013)
  • Author(s): Kyoko Tsukiyama-Kohara, Asao Katsume, Kazuhiro Kimura, Masayuki Saito, and Michinori Kohara
  • Journal Title: Genes to Cells Volume: 未定
  • Peer Reviewed
• [Journal Article] Immunization with a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virus suppresses viral protein levels in mouse liver. (2012)
  • Author(s): Sekiguchi, S, Kimura K, Chiyo T, Ohtsuki T, Tobita Y, Tokunaga Y, Yasui F, Tsukiyama-Kohara K, Wakita T, Tanaka T, Miyasaka M, Mizuno K, Hayashi Y, Hishima T, Matsushima K and Kohara M.
  • Journal Title: PLoS One Volume: 7 Issue: 12 Pages: e51656-e51656
  • DOI: 10.1371/journal.pone.0051656
  • Peer Reviewed
• [Journal Article] Role of oxidative stress in hepatocarcinogenesis induced by hepatitis C virus. (2012)
  • Author(s): Tsukiyama-Kohara, K.
  • Journal Title: Int J Mol Sci Volume: 13 Issue: 11 Pages: 15271-8
  • DOI: 10.3390/ijms131115271
  • Peer Reviewed
• [Journal Article] Impairment of interferon regulatoroy factor-3 activation by hepatitis C virus core protein basic amino acid region 1. (2012)
  • Author(s): Inoue K, Tsukiyama-Kohara K, Matsuda C, Yoneyama M, Fujita T, Kuge S, Yoshida M, Kohara M
  • Journal Title: Bichem Biophys Res Commun Volume: 428 Issue: 4 Pages: 494-499
  • DOI: 10.1016/j.bbrc.2012.10.079
  • Peer Reviewed
• [Journal Article] Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1. (2012)
  • Author(s): Saito M, Kohara, M, Tsukiyama-Kohara K.
  • Journal Title: J Med Virol Volume: 84 Issue: 5 Pages: 733-746
  • DOI: 10.1002/jmv.23250
  • Peer Reviewed
• [Journal Article] Translocase of outer mitochondrial membrane 70 induces interferon response and is impaired by hepatitis C virus NS3. (2012)
  • Author(s): Kasama Y, Saito M, Takano T, Nishimura T, Satoh M, Wang Z, Nagla. E. S., Harada S, Kohara M, Tsukiyama-Kohara K.
  • Journal Title: Virus Research Volume: 163 Issue: 1 Pages: 405-9
  • DOI: 10.1016/j.virusres.2011.10.009
  • Peer Reviewed
• [Journal Article] Selective translation of the measles virus nucleocapsid mRNA by la protein (2011)
  • Author(s): Inoue Y, Sato H, Fujita K, Tsukiyama-Kohara K, Yoneda M, Kai C
  • Journal Title: F ront Microbiol Volume: 2 Pages: 173-173
  • DOI: 10.3389/fmicb.2011.00173
  • Peer Reviewed
• [Journal Article] Monoclonal antibody 2-152a suppresses hepatitis C virus infection thorough betaine/GABA transporter-1 (2011)
  • Author(s): Satoh M, Saito M, Takano T, Kasama Y, Nishimura T, Nishito Y, Hirata Y, Arai M, Sudoh M, Kai C, Kohara M and Tsukiyama-Kohara K
  • Journal Title: J Infect Dis Volume: 204(8) Issue: 8 Pages: 1172-1180
  • DOI: 10.1093/infdis/jir501
  • Peer Reviewed
• [Journal Article] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes (2011)
  • Author(s): Takano T, Tsukiyama-Kohara K, Hayashi M, Hirata Y, Satoh M, Tateno C, Hayashi Y, Hishima T, Funata N, Sudo M, and Kohara M
  • Journal Title: J Hepatology Volume: 55(3) Issue: 3 Pages: 512-521
  • DOI: 10.1016/j.jhep.2010.12.011
  • Peer Reviewed
• [Journal Article] Translocase of outer mitochondrial membrane 70 expression is induced by hepatitis C virus and is related to the apoptotic response (2011)
  • Author(s): Takano T, Kohara M, Kasama Y, Nishimura T, Saito M, Kai C and Tsukiyama-Kohara K
  • Journal Title: J Med Virol Volume: 83 Issue: 5 Pages: 801-809
  • DOI: 10.1002/jmv.22046
  • Peer Reviewed
• [Journal Article] Hepatitis C virus-related lymphomagenesis in a mouse model (2011)
  • Author(s): Tsukiyama-Kohara K, Sekiguchi S, Kasama Y, Salem NE, Machida K, Kohara M
  • Journal Title: ISRN Hemato Volume: 2011 Pages: 167501-167501
  • DOI: 10.5402/2011/167501
  • Peer Reviewed
• [Journal Article] Potential of a recombinant measles virus as expression vector of hepatitis C virus envelope proteins (2011)
  • Author(s): Kasama Y, Satoh M, Saito M, Okada S, Kai C, and Tsukiyama-Kohara K
  • Journal Title: World J Vaccine Volume: 1 Issue: 03 Pages: 98-103
  • DOI: 10.4236/wjv.2011.13010
  • Peer Reviewed
• [Presentation] Tumorigenicity induced by hepatitis C virus (2014)
  • Author(s): Tukiyama-Kohara K, Kohara M
  • Organizer: 第4回新学術領域発がんスパイラル国際シンポジウム
  • Place of Presentation: 札幌
  • Year and Date: 2014-02-11
• [Presentation] Tumorigenicity inducued by hepatitis C virus. (2014)
  • Author(s): Tsukiyama-Kohara K., Kohara M
  • Organizer: 第4回新学術領域 発がんスパイラル国際シンポジウム
  • Place of Presentation: 札幌
  • Invited
• [Presentation] 型肝炎ウイルス誘導性酸化ストレスによる肝細胞腫瘍原性更新 (2013)
  • Author(s): 小原恭子
  • Organizer: 第24回日本生体防御学会
  • Place of Presentation: 熊本
  • Year and Date: 2013-07-12
• [Presentation] Chronic hepatitis C virus model in Tupaia belangeri (2013)
  • Author(s): Tsukiyama-Kohara K, Amako Y, Kohara M
  • Organizer: SIMPOSIUM"HCV animal models and vaccine development"
  • Place of Presentation: Tallinn, Estonia
  • Year and Date: 2013-05-17
• [Presentation] Inflammation and cancer in hepatitis C virus infection (2013)
  • Author(s): Tsukiyama-Kohara K, Kimuara K, Kohara M
  • Organizer: 3rd IGAKUKEN International Symposium on Control of Influenza and Hepatitis
  • Place of Presentation: Tokyo
  • Year and Date: 2013-02-15
• [Presentation] Chronic hepatitis C virus model in Tupaia belangeri (2013)
  • Author(s): Tsukiyama-Kohara K, Amako Y, Kohara M.
  • Organizer: Symposium HCV Animal models and vaccine development
  • Place of Presentation: Estonia
  • Invited
• [Presentation] C型肝炎ウイルス誘導性酸化ストレスによる肝細胞腫瘍原性亢進 (2013)
  • Author(s): 小原 恭子
  • Organizer: 第24回日本生体防御学会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] Development of tupaia nelangeri for small animal infection model of hepatitis B virus, according to the genome research, (2013)
  • Author(s): Tsukiyama-Kohara, K, Hirata, Y.,Sanada T, Yamamoto N., Yasui F, Kohara, M,
  • Organizer: HBV2013
  • Place of Presentation: 上海(中国）
• [Presentation] C型肝炎ウイルスのBリンパ腫発症要因の解明 (2013)
  • Author(s): 笠間由里、小原道法、小原恭子,
  • Organizer: 第50回日本ウイルス学会九州支部会
  • Place of Presentation: 長崎
• [Presentation] Efficacy of French maritime pine bark extract pycnogenolR to hepatitis C virus replication. (2013)
  • Author(s): EZZIKOURI S, Nishimura T, Ozawa M, Kohara M and Tsukiyama-Kohara K.
  • Organizer: 第50回ウイルス学会九州支部会
  • Place of Presentation: 長崎
• [Presentation] ツパイとヒトとの遺伝的相同性の検証 (2013)
  • Author(s): 金澤伯弘、川畑淑子、永野希織、小原道法、小澤真、小原恭子.
  • Organizer: 日本獣医学会学術集会
  • Place of Presentation: 岐阜
• [Presentation] 宿主因子阻害剤NA８０８と直接的複製阻害剤の併用による抗HCV活性 (2013)
  • Author(s): 徳永優子、平田雄一、小原恭子、小原道法
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] C型肝炎誘発性リンパ腫発症モデルマウスの網羅的解析 (2013)
  • Author(s): 笠間由里、小原道法、小原恭子
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] Critical factors in HCV related B-cell lymphoma development characterized by comprehensive analysis of B-lymphoma cells in the HCV transgenic mice (2013)
  • Author(s): Tsukiyama-Kohara, K, Kasama, Y, Kohara, M
  • Organizer: 20th HCV Symposium
  • Place of Presentation: オーストラリア
• [Presentation] Inflammation and Cancer in Hepatitis C virus Infection (2012)
  • Author(s): Tsukiyama-Kohara K, Kimuara K, Kohara M
  • Organizer: International symposium : Infection, immunity and cancer
  • Place of Presentation: Kyoto
  • Year and Date: 2012-01-17
• [Presentation] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. (2012)
  • Author(s): Takashi Takano, Kyoko Tsukiyama-Kohara, Michinori Kohara.
  • Organizer: Congress of European Association for the Study of the Liver (EASL2012).
  • Place of Presentation: Barcellona
• [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. (2012)
  • Author(s): K. Tsukiyama-Kohara, M. Kohara.
  • Organizer: 第11回あわじしま感染症;免疫フォーラム
  • Place of Presentation: 兵庫
• [Presentation] Antibody against 3β-Hydroxysterol-Δ24-Reductase Suppresses Hepatitis C Virus Infection through Betaine/GABA Transporter-1 (2012)
  • Author(s): Satoh, M., Kohara, M., Tsukiyama-Kohara, K.
  • Organizer: HCV2012
  • Place of Presentation: Venice
• [Presentation] C型肝炎ウイルスの複製に関与する新規宿主因子BGT-1. (2012)
  • Author(s): 佐藤正明、齊藤誠、小原道法、小原恭子
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] C型肝炎ウイルスのBリンパ腫発症要因解明に向けた研究. (2012)
  • Author(s): 小原恭子、笠間由里、小原道法.
  • Organizer: 第６０回日本ウイルス学会
  • Place of Presentation: 大阪
• [Presentation] Elevation of apoptosis induced by mutant DHCR24 with potential MDM2 binding motif in hepatocytes. (2012)
  • Author(s): Qi, X, Harada, S., Tsukiyama-Kohara, K.
  • Organizer: 第６０回日本ウイルス学会
  • Place of Presentation: 大阪
• [Presentation] Modification of translocase of outer mitochondrial membrane 70 by hepatitis C virus in apoptotic response and interferon induction. (2012)
  • Author(s): Takano, T., Kasama, Y., Kohara, M., Tsukiyama-Kohara, K.
  • Organizer: 第３５回日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] Inflammation and Cancer in Hepatitis C virus Infection (2012)
  • Author(s): Kyoko Kohara, Kiminori Kimura, Michinori Kohara
  • Organizer: International symposium: Infection, immunity and cancer(招待講演)
  • Place of Presentation: 京都
• [Presentation] C型肝炎ウイルス誘発性リンパ腫モデルマウスの樹立と解析 (2011)
  • Author(s): 笠間由里
  • Organizer: 第7回麒麟塾
  • Place of Presentation: 東京
  • Year and Date: 2011-06-04
• [Presentation] Spontaneous development of B-cell lymphomas by persistent expression of the full genome of hepatitis C virus in B cells in mice. (2011)
  • Author(s): Tsukiyama-Kohara K, Kasama Y and Kohara M.
  • Organizer: "Recent Advances in pathogenic human viruses" in 2011 ASBMB Special symposia series.
  • Place of Presentation: Guanzhou, China
• [Presentation] Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. (2011)
  • Author(s): Takano T, Tsukiyama-Kohara K, Hirata Y, Tokunaga Y, Tateno C, Sudoh M, and Kohara M.
  • Organizer: The 18th international meeting on Hepatitis C virus and related viruses
  • Place of Presentation: Seatle, USA
• [Presentation] Hepatitis C virus induces translocase of outer mitochondria membrane 70 which regulates apoptotic response. (2011)
  • Author(s): Takano T, Kasama Y, Kohara M, and Tsukiyama-Kohara K.
  • Organizer: The 18th international meeting on Hepatitis C virus and related viruses
  • Place of Presentation: Seatle, USA
• [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in mice. (2011)
  • Author(s): Kasama Y, Sekiguchi S, and Kohara M, Tsukiyama-Kohara K
  • Organizer: The 18th international meeting on Hepatitis C virus and related viruses
  • Place of Presentation: Seatle, USA
• [Presentation] Application of DHCR24 for the diagnosis of hepatocellular carcinoma (HCC). (2011)
  • Author(s): Nagla ES, Nishimura T, Saito M, Kohara M, Harada S, El-Gohary A, and Tsukiyama-Kohara K.
  • Organizer: International Union of Microbiological Societies
  • Place of Presentation: Sapporo, Japan
• [Presentation] Overexpression of 3beta-Hydroxysterol delta24Reductase is induced by hepatitis C virus infection through oxidative stress mediated Sp1 activation. (2011)
  • Author(s): Saito M, Kohara M, and Tsukiyama-Kohara K.
  • Organizer: International Union of Microbiological Societies
  • Place of Presentation: Sapporo, Japan
• [Presentation] Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo. (2011)
  • Author(s): Kasama Y, Sekiguchi S, Saito M, Satoh M, Kuwahara K, Takeya M, Sakaguchi N, Kohara M, Tsukiyama-Kohara K.
  • Organizer: International Union of Microbiological Societies
  • Place of Presentation: Sapporo, Japan
• [Presentation] C型肝炎ウイルス誘発性リンパ腫発症モデルマウスの樹立と解析 (2011)
  • Author(s): 笠間 由里、関口敏、齊藤誠、佐藤正明、桑原一彦、阪口薫雄、竹屋元裕、日浅陽一、小原道法、小原恭子
  • Organizer: 第７回麒麟塾(招待講演)
  • Place of Presentation: 東京
• [Presentation] 新規C型肝癌マーカーDHCR24を利用した分子標的治療の開発 (2011)
  • Author(s): 齊藤誠、小原恭子
  • Organizer: 第48回日本ウイルス学会九州支部会
  • Place of Presentation: 北九州
• [Presentation] Role of DHCR24 in hepatitis C virus replication in hepatocytes. (2011)
  • Author(s): Takano K, Kohara M, and Tsukiyama-Kohara K.
  • Organizer: 第７０回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Recombinant vaccinia virus encoding hepatitis C virus nonstructuralprotein cures chronic hepatitis in mouse model. (2011)
  • Author(s): Kohara M, Kimura K, Tsukiyama-Kohara K.
  • Organizer: 第７０回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Molecular target therapy for hepatitic C virus-related hepatocellular carcinoma with cell-surface expression of DHCR24 (2011)
  • Author(s): Saito M, Tsukiyama-Kohara K
  • Organizer: 第７０回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Exploitation of molecular targeting therapy for hepatitis C virus-related hepatocellular carcinoma forcusing on DHCR24. (2011)
  • Author(s): Saito M, Tsukiyama-Kohara K.
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] French marine bark extract pycnogenol is a new candidate of Hepatitis C virus therapeutic material. (2011)
  • Author(s): Nishimura T，Kohara M，Kino Y，Tsukiyama-Kohara K.
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜
• [Presentation] Inflammation and cancer in hepatitis C virus infection.
  • Author(s): Tsukiyama-Kohara, K., Kimura, K., Kohara, M.
  • Organizer: 3rd_IGAKUKEN International Symposium on Control of Influenza and Hepatitis
  • Place of Presentation: 東京
  • Invited
• [Book] 新時代のウイルス性肝炎学, 日本臨床69巻増刊4別刷, HCVの病原性発現に関与するウイルス因子とその機能II C型肝炎C型肝炎ウイルス感染における免疫応答と感染防御機構 (2011)
  • Author(s): 小原恭子、棟方翼、小原道法
• [Book] BIO Clinica 26 (10), C型肝炎ウイルスによる免疫攪乱と炎症発がん (2011)
  • Author(s): 小原道法、小原恭子
• [Book] 肝臓, 疾患モデルマウス:表現型解析指南 (2011)
  • Author(s): 小原恭子、小原道法
  • Publisher: 中山書店
• [Book] HCVの病原性発現に関与するウイルス因子とその機能 (2011)
  • Author(s): 小原恭子、棟方翼、小原道法
  • Total Pages: 6
  • Publisher: 日本臨床
• [Book] C型肝炎ウイルスによる免疫攪乱と炎症発がん (2011)
  • Author(s): 小原道法、小原恭子
  • Total Pages: 7
  • Publisher: Bio Clinica
• [Book] 肝臓 (2011)
  • Author(s): 小原恭子、小原道法
  • Total Pages: 5
  • Publisher: 「疾患モデルマウス：表現型解析指南(中山書店）」
• [Remarks]
  • URL: http://www.vet.kagoshima-u.ac.jp/kadai
• [Remarks] 鹿児島大学 動物衛生学分野
  • URL: http://www.vet.kagoshima-u.ac.jp/kadai/V-douei/douei/index.php
• [Remarks] 鹿児島大学共同獣医学部動物衛生学分野
  • URL: http://www.vet.kagoshima-u.ac.jp/kadai/V-douei/douei/index.php
• [Remarks]
  • URL: http://www.vet.kagoshima-u.ac.jp/kadai/V-douei/douei/index.php
• [Patent(Industrial Property Rights)] C型肝炎の予防、治療、又は改善用組成物 (2012)
  • Inventor(s): 小原恭子、松森昭 他
  • Industrial Property Rights Holder: 松森昭、化学及血清療法研究所、東京都医学研究機構、熊本大学
  • Industrial Property Rights Type: 特許
  • Patent Publication Number: 2012-250940
  • Filing Date: 2012-12-20
• [Patent(Industrial Property Rights)] C型肝炎の予防、治療又は改善用組成物 (2011)
  • Inventor(s): 小原恭子、松森昭、西村 知裕、小原道法
  • Industrial Property Rights Holder: 国立大学法人熊本大学、松森昭、(一般財団法人)化学及血清療法研究所、(公財)東京都医学研究機構
  • Industrial Property Number: 2011-125440
  • Filing Date: 2011-06-03
• [Patent(Industrial Property Rights)] C型肝炎の予防、治療又は改善用組成物 (2011)
  • Inventor(s): 小原恭子、松森昭、西村知裕、小原道法
  • Industrial Property Rights Holder: 熊本大学、松森昭、化学及血清療法研究所、東京都医学研究機構
  • Filing Date: 2011
• [Patent(Industrial Property Rights)] C型肝炎ウイルス阻害剤
  • Inventor(s): 小原恭子、小原道法 他
  • Industrial Property Rights Holder: (一般財団法人)化学及血清療法研究所、(公財) 東京都医学研究機構、国立大学法人熊本大学
  • Overseas
• [Patent(Industrial Property Rights)] Hepatitis C virus inhibitors
  • Inventor(s): 小原恭子、小原道法 他
  • Industrial Property Rights Holder: (一般 財団法人)化学及血清療法研究所、(公財) 東京都医学研究機構、国立大学法人熊本大学
  • Overseas