A novel biomarker predicting the response to pegylated interferon-alpha plus ribavirin in patients with chronic hepatitis C
Project/Area Number |
23590553
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Virology
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Research Institution | St. Marianna University School of Medicine |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OKUSE Chiaki 聖マリアンナ医科大学, 医学部, 准教授 (00318940)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | バイオマーカー / C型肝炎 / 血清ペプチド / 補体 / ペグインターフェロンα・リバビリン療法 / INFα/RBV療法 / 治療効果予測 / ペプチドミクス / IFNα/RBV療法 |
Research Abstract |
Novel biomarkers predicting sustained virological response (SVR) to pegylated interferon alpha plus ribavirin (PEG-IFNalpha/RBV) were investigated. Peptides in pretreatment sera from patients with hepatitis C virus (HCV) were comprehensively analyzed by mass spectrometry. In total, 107 peptides were detected in a training set (n=23). In all the responders (who achieved SVR) and the non-responders (n=96), sensitivity and specificity of SVR in a model consisting of ion intensity of 107 peptides, hemoglobin, BMI, and age were 70% and 92%, and those in another model consisting of ion intensity of complement 3f des-arginine (C3f-dR) and platelet count were 59% and 88%, respectively. Taken together, serum peptides, especially C3f-dR, would be useful predictors for SVR to PEG-IFNalpha/RBV. The complements may be involved in the HCV elimination.
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Report
(4 results)
Research Products
(147 results)
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[Journal Article] Prediction of response to treatment by gene expression profiling of peripheral blood in patients with microscopic polyangiitis.2013
Author(s)
Ishizu A, Tomaru U, Murai T, Yamamoto T, Atsumi T, Yoshiki T, Yumura W, Yamagata K, Yamada H, Kumagai S, Kurokawa MS, Suka M, Makino H, Ozaki S.
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Journal Title
PLOS ONE
Volume: 8
Issue: 5
Pages: e63182-e63182
DOI
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Peer Reviewed
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[Journal Article] Roles of serum fibrinogen α chain-derived peptides in Alzheimer's disease.2013
Author(s)
Noguchi M, Sato T, Nagai K, Utagawa I, Suzuki I, Arito M, Iizuka N, Suematsu N, Okamoto K, Kato T, Yamaguchi N, Kurokawa MS.
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Journal Title
International Journal of Geriatric Psychiatry
Volume: in press
Issue: 8
Pages: 808-818
DOI
NAID
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Peer Reviewed
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[Journal Article] Tolvaptan for improvement of hepatic edema: A phase 3, multicenter, randomized, double-blind, placebo-controlled trial.2013
Author(s)
Sakaida I, Kawazoe S, Kajimura K, Saito T, Okuse C, Takaguchi K, Okada M, Okita K.
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Journal Title
Hepatology Research
Volume: 44
Issue: 1
Pages: 73-82
DOI
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Peer Reviewed
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[Journal Article] High levels of hepatitis B virus after the onset of disease lead to chronic infection in patients with acute hepatitis B.2013
Author(s)
Yotsuyanagi H, Ito K, Yamada N, Takahashi H, Okuse C, Yasuda K, Su¬zuki M, Moriya K, Mizokami M, Miyakawa Y, Koike K.
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Journal Title
Clinical Infectious Diseases
Volume: 57
Issue: 7
Pages: 935-942
DOI
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Peer Reviewed
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[Journal Article] Comparative proteomic analysis of neutrophils from patients with microscopic polyangiitis and granulomatosis with polyangiitis.2013
Author(s)
Uchida T, Nagai K, Sato T, Iizuka N, Arito M, Takakuwa Y, Nakano H, Ooka S, Kurokawa MS, Suematsu N, Okamoto K, Ozaki S, Kato T.
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Journal Title
Journal of Proteomics
Volume: 91C
Pages: 259-69
NAID
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Peer Reviewed
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[Journal Article] Protein profiles of peripheral blood mononuclear cells as a candidate biomarker for Behcet’s disease.2013
Author(s)
Yoshioka T, Kurokawa MS, Sato T, Nagai K, Iizuka N, Arito M, Takakuwa Y, Nakano H, Ooka S, Suematsu N, Okamoto K, Yudoh K, Nakamura H, Suzuki N, Ozaki S, Kato T.
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Journal Title
Clinical and Experimental Rheumatology
Volume: in press
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Peer Reviewed
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[Journal Article] Effect of sulfasalazine and tofacitinib on the protein profile of articular chondrocytes.2013
Author(s)
Endo W, Arito M, Sato T, Kurokawa MS, Omoteyama K, Iizuka N, Okamoto K, Suematsu N, Nakamura H, Beppu M, Kato T.
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Journal Title
Modern Rheumatology
Volume: in press
NAID
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Peer Reviewed
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[Journal Article] Proteomic analysis of whole glomeruli in patients with IgA nephropathy using micro-sieving.2013
Author(s)
Kojima S, Koitabashi K, Iizuka N, Okamoto K, Arito M, Sato T, Kurokawa MS, Suematsu N, Shibagaki Y, Yasuda T, Kimura K, Kato T.
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Journal Title
American Journal of Nephrology
Volume: in press
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Peer Reviewed
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[Journal Article] Case of Nonalcoholic Steatohepatitis Occurring in Combination with Sleep Apnea Syndrome, Who Showed Improvement of Liver Function by Continuous Positive Airway Pressure.2013
Author(s)
Shigefuku R, Takahashi H, Ikeda H, Matsunaga K, Koike J, Maeyama S, Matsumoto N, Okuse C, Itoh F, Suzuki M.
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Journal Title
Journal of Clinical Case Reports
Volume: 3
Pages: 3-3
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Peer Reviewed
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[Journal Article] Case of Acute Hepatitis B of Genotype H Resulting in Persistent Infection.2013
Author(s)
Yamada N, Shigefuku R, Sugiyama R, Kobayashi M, Ikeda H, Takahashi H, Okuse C, Suzuki M, Itoh F, Yotsuyanagi H, Yasuda K, Moriya K, Koike K, Wakita T, Kato T.
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Journal Title
World Journal of Gastroenterology
Volume: in press
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Peer Reviewed
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[Journal Article] Severity-based treatment for Japanese patients with MPO-ANCA-associated vasculitis : the JMAAV study2011
Author(s)
Ozaki S, Atsumi T, Hayashi T, Ishizu A, Kobayashi S, Kumagai S, Kurihara Y, Kurokawa M, Makino H, Nagafuchi H, Nakabayashi K, Nishimoto N, Suka M, Tomino Y, Yamada H, Yamagata K, Yoshida M, Yumura W
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Journal Title
Mod Rheumatol
Volume: (Epub ahead of print)
Issue: 3
Pages: 394-404
DOI
NAID
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Peer Reviewed
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[Presentation] Serum peptides, represented by complement 3f des-arginine, are useful for prediction of the response to pegylated interferon-α plus ribavirin in patients with chronic hepatitis C.2013
Author(s)
Noguchi Y, Kurokawa MS, Okuse C, Matsumoto N, Nagai K, Sato T, Arito M, Suematsu N, Okamoto K, Suzuki M, Itoh F, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Comparative croteomic analysis of neutrophils from patients with microscopic polyangiitis and granulomatosis with polyangiitis.2013
Author(s)
Uchida T, Nagai K, Sato T, IizukaN, Arito M, Takakuwa Y, Nakano H, Ooka S, Kurokawa MS, Suematsu N, Okamoto K, Ozaki S, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Protein profiles of peripheral blood mononuclear cells as a biomarker for Behcet’s Disease.2013
Author(s)
Yoshioka T, Kurokawa MS, Sato T, Nagai K, Iizuka N, Arito M, Takakuwa Y, Nakano H, Ooka H, Suematsu N, Okamoto K, Nakamura H, Suzuki N, Ozaki S, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Comprehensive analysis of aberrantly glycosylated proteins in rheumatoid arthritis.2013
Author(s)
Sato T, Arito M, Kurokawa MS, Takakuwa Y, Ooka S, Nagai K, Nakamura H, Iizuka N, Suematsu N, Okamoto K, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Serum peptide profiles as a candidate biomarker for dementia with lewy bodies.2013
Author(s)
Suzuki I, Kurokawa MS, Noguchi M, Sato T, Utagwa I, Arito M, Iizuka N, Omoteyama K, Suematsu N, Okamoto K, Yamaguchi N, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Proteomic analysis of whole glomeruli in patients with IgA nephropathy using micro-sieving.2013
Author(s)
Kojima S, Koitabashi K, Nobuko Iizuka N, Okamoto K, Arito M, Sato T, Kurokawa MS, Suematsu N, Yasuda T, Kimura K, Kato T.
Organizer
HUPO2013
Place of Presentation
Pacifico Yokohama(Kanagawa)
Related Report
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[Presentation] Protein profiles of peripheral blood mononuclear cells as a biomarker for Behcet’s Disease.2013
Author(s)
Kurokawa MS, Yoshioka T, Sato T, Nagai K, Iiduka N, Arito M, Takakuwa Y, Nakano H, Ooka S, Suematsu N, Okamoto K, Nakamura H, Suzuki N, Ozaki S, Kato T.
Organizer
American College of Rheumatology. Annual meeting 13
Place of Presentation
San Diego(USA)
Related Report
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[Presentation] Amino acid polymorphisms of Sregion of hepatitis B virus in acute hepatitis B patients in Japan.2013
Author(s)
Yamada N, Sugiyama R, Wakita T, Kato T, Yasuda K, Yotsuyanagi H, Moriya K, Koike K, Okuse C, Suzuki M, Itoh F.
Organizer
The 64th Annual Meeting of the American Association for the Study of Liver Diseases.
Place of Presentation
Washington,D.C.(USA)
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