| Project/Area Number |
23590554
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Virology
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
NAGATA Noriyo 国立感染症研究所, 感染病理部, 室長 (30270648)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Hiroyuki 国立感染症研究所, ウイルス第二部, 室長 (90270644)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
IWATA Naoko 国立感染症研究所, 感染病理部, 主任研究官 (10360695)
SUZUKI Tadaki 国立感染症研究所, 感染病理部, 室長 (30527180)
|
|---|
| Research Collaborator |
KOTANI Osamu 国立感染症研究所, 感染病理部, 研究生
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 感染症 / ウイルス / 病理学 / 動物モデル / 病原性 |
|---|
| Research Abstract |
Saffold virus (SAFV) has been isolated and/or detected from human cases of diarrhea and upper respiratory tract inflammation in worldwide since the first report in 2007 and were considered epidemiologically that most people generally infected in early childhood. However, SAFV has been detected in the some cases of non-polio acute flaccid paralysis and a few cases of neuronal disorders. Then SAFV possibly be neurovirulent to human.
To understand the pathogenesis of SAFV, first of all, we established a detection system of virus antigen and virus genome in pathological diagnosis. Next, we evaluated the susceptibility of experimental animals to SAFV using two clinical isolates of SAFV. Then we attempted to generate an animal model of cerebellar hypoplasia after SAFV infection using neonatal mice.
|
