| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
TRAX (Translin-associated factor X) is known as a component of RISC (RNA-induced silencing complex) that is involved in RNA interference (RNAi). Given the significant role of TRAX on RNAi machinery, we analyzed its effect on the mechanism of persistent infection of hepatitis C virus (HCV). Although we could not prove the involvement of TRAX in HCV infection during the study period, we obtained the following results for the nature of TRAX molecule: 1)TRAX protein alone cannot be cellularly expressed. 2)TRAX protein usually exists as a complex with Translin protein to escape from ubiquitin-independent proteasome degradation pathway 3) The C-terminal region of TRAX protein is susceptible to degradation.
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